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Early use of statins after coronary syndromes does not reduce risk of heart attack, stroke or death
May 03, 2006Beginning use of statins within 14 days of acute coronary syndromes (such as heart attack or unstable angina) does not decrease the risk of death, heart attack, or stroke, for up to 4 months, based on a meta-analysis of previously published studies, according to an article in the May 3 issue of JAMA.
Numerous clinical trials and meta-analyses show that long-term therapy with statins reduces the risk of myocardial infarction (MI - heart attack), stroke, and death in patients at varying risks for cardiovascular disease, according to background information in the article. The short-term effects of early treatment with statins in patients after the onset of acute coronary syndrome (ACS, including MI or unstable angina) for these outcomes is unclear.
Matthias Briel, M.D., of the University Hospital Basel, Switzerland and colleagues conducted a meta-analysis of previous randomized controlled trials to determine whether early use of statins within 14 days following the onset of ACS reduces cardiovascular illness and overall death at 1 and 4 months. The researchers identified 12 trials involving 13,024 patients with ACS.
The researchers found that there were no statistically significant risk reductions from early statin therapy for total death, total MI, total stroke, cardiovascular death, fatal or nonfatal MI, or revascularization procedures (percutaneous coronary intervention or coronary artery bypass graft) at 1 month and 4 months of follow-up. The researchers add that serious adverse events associated with early initiation of statins are rare.
JAMA and Archives Journals
The researchers found that there were no statistically significant risk reductions from early statin therapy for total death, total MI, total stroke, cardiovascular death, fatal or nonfatal MI, or revascularization procedures (percutaneous coronary intervention or coronary artery bypass graft) at 1 month and 4 months of follow-up. The researchers add that serious adverse events associated with early initiation of statins are rare.
JAMA and Archives Journals
Statins Current Events and Statins News RSSEarly end to key study on benefits of niacin, a B vitamin, in keeping arteries open was premature
Heart experts at Johns Hopkins are calling premature the early halt of a study by researchers at Walter Reed Army Medical Center and Washington Hospital Center on the benefits of combining extended-release niacin, a B vitamin, with cholesterol-lowering statin medications to prevent blood vessel narrowing.
Researchers mobilizing global resources to test new treatments for severe H1N1 infection
An important, ground-breaking initiative is unfolding in the global critical care community in response to the H1N1 pandemic.
Widely used cholesterol-lowering drug may prevent progression
Simvastatin, a commonly used, cholesterol-lowering drug, may prevent Parkinson's disease from progressing further. Neurological researchers at Rush University Medical Center conducted a study examining the use of the FDA-approved medication in mice with Parkinson's disease and found that the drug successfully reverses the biochemical, cellular and anatomical changes caused by the disease.
Statins show dramatic drug and cell dependent effects in the brain
Besides their tremendous value in treating high cholesterol and lowering the risk of heart disease, statins have also been reported to potentially lower the risks of other diseases, such as dementia.
Cholesterol-lowering medicines may be effective against cancer
Statins lower cholesterol by blocking certain enzymes involved in our metabolism.
Adding ezetimibe to atorvastatin improves lipid control
Adding ezetimibe to atorvastatin significantly boosted the attainment of lipid targets as specified by both Canadian and European guidelines in elderly patients aged 65 and older and the combination produced superior results than simply increasing the dose of atorvastatin alone.
Use of statins favors the wealthy, creating new social disparities in cholesterol
Since the introduction of statins to treat high cholesterol, the decline in lipid levels experienced by the wealthy has been double that experienced by the poor.
Women with Atrial Fibrillation Are at Significantly Higher Risk of Stroke and Death Compared to Men and Receive Less Attention
Even though the incidence of atrial fibrillation is higher in men than women, a review of past studies and medical literature completed by cardiac experts at Rush University Medical Center shows that women are more likely than men to experience symptomatic attacks, a higher frequency of recurrences, and significantly higher heart rates during atrial fibrillation, which increases the risk of stroke.
Pre-hospital organization: The first links in the chain of survival for heart attack patients
Mortality rate following a heart attack has fallen by more than 50% in Europe over the past 25 years. However, because only minor advances in the medical treatment of AMI are expected over the next decade, it is through organisational changes in the pre-hospital phase that mortality rate will continue this decline to below 5%.
Fatostatin' is a turnoff for fat genes
A small molecule earlier found to have both anti-fat and anti-cancer abilities works as a literal turnoff for fat-making genes, according to a new report in the August 28th issue of the journal Chemistry and Biology, a Cell Press journal.
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Aidan C-Statin - 120 Capsules by Aidan C-Statin, a naturally occurring plant extract, contains a patented proteoglycan molecule (PGM) from field bindweed that is a potent angiogenesis inhibitor. Studies have demonstrated PGM to be 100 times stronger than shark cartilage. Used and recommended by healthcare professionals around the world. C-STATIN is a proprietary extract of Convolvulus arvensis hat contains high concentrations of active PGMs. |
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