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Early myocardial enhancement defects on multidetector CT predicts future myocardial viability
May 03, 2006Early myocardial enhancement defects (dark spots) on multidetector CT are valuable predictors of myocardial viability in patients who have suffered a heart attack, reported doctors from the departments of cardiology and radiology at Rambam Medical Center in Haifa, Israel.
Gated CT coronary angiography was performed on 34 consecutive patients that were admitted with a diagnosis of a heart attack. Each patient also underwent an initial and follow-up echocardiography examination. "We wanted to be able to see the heart muscle at the time of the heart attack and then compare that to the muscle's functional recovery on the follow-up echocardiography examination two to four months later," said Eduard Ghersin, MD, leading radiology researcher of the study.
The multidetector CT data was assessed for the presence, position and size of early myocardial enhancement defects (dark spots) by a radiologist blinded to the clinical diagnosis and to the results of echocardiography. The dark spots indicate regions of the heart muscle that had reduced blood flow because of the heart attack.
"Our main conclusion is that in heart attack patients, early myocardial enhancement defects on cardiac multidetector CT, are valuable predictors of future myocardial viability," said Dr. Ghersin. "In essence, what we found is that dark spots on the early CT predicted those patients who would have reduced myocardial viability on follow-up echocardiography," said Dr. Ghersin. "Consequently, imaging physicians and clinicians should be aware of the potential advantages of systematic assessment of myocardial enhancement on routine CT coronary angiography studies in the clinical context of heart attack patients."
"As many other radiologists, we also primarily focused on imaging of the coronary arterial tree using recent advances in multidetector CT technology," stated Dr. Ghersin. "The fact that the same technology can supply valuable additional information at no or slightly increased additional cost in terms of radiation exposure to patients, significantly amplifies the future use of cardiac multidector CT."
The full results of this study will be presented on Wednesday, May 3, 2006 during the American Roentgen Ray Society Annual Meeting in Vancouver, BC.
American Roentgen Ray Society
"Our main conclusion is that in heart attack patients, early myocardial enhancement defects on cardiac multidetector CT, are valuable predictors of future myocardial viability," said Dr. Ghersin. "In essence, what we found is that dark spots on the early CT predicted those patients who would have reduced myocardial viability on follow-up echocardiography," said Dr. Ghersin. "Consequently, imaging physicians and clinicians should be aware of the potential advantages of systematic assessment of myocardial enhancement on routine CT coronary angiography studies in the clinical context of heart attack patients."
"As many other radiologists, we also primarily focused on imaging of the coronary arterial tree using recent advances in multidetector CT technology," stated Dr. Ghersin. "The fact that the same technology can supply valuable additional information at no or slightly increased additional cost in terms of radiation exposure to patients, significantly amplifies the future use of cardiac multidector CT."
The full results of this study will be presented on Wednesday, May 3, 2006 during the American Roentgen Ray Society Annual Meeting in Vancouver, BC.
American Roentgen Ray Society
Myocardial Current Events and Myocardial News RSSInhibition of GRK2 is protective against acute cardiac stress injuries
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion.
Concurrent imaging of metabolic and electric signals in the heart
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Survival after heart attack improves in younger women
In recent years, women, particularly younger women, experienced larger improvements in hospital mortality after myocardial infarction (MI) than men, according to a study published in the Oct. 26, 2009 issue of Archives of Internal Medicine.
Cost Effectiveness of Blood Pressure Device Evaluated
A study conducted by the University of Rochester Medical Center (URMC) demonstrates that, for certain patient populations, an experimental device that lowers blood pressure may be a cost effective treatment. The implantable device, called Rheos, is in advanced stages of testing for individuals with drug resistant hypertension.
Drug-eluting stents better than bare-metal stents for heart attack patients
Late-breaking data from the landmark HORIZONS-AMI clinical trial, presented at the 21st annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, demonstrated that after two years, in heart attack patients, the use of a drug-eluting stent (paclitaxel) was safer and more effective than a bare-metal stent; and that the administration of the anticoagulant medication bivalirudin enhanced safety and efficacy compared to the use of heparin + GPIIb/IIIa inhibitors.
SPIRIT IV trial shows everolimus stent sets new standard for event-free survival
Late-breaking data from SPIRIT IV, a large-scale multi-center study of nearly 4,000 patients in the U.S., shows that an everolimus-eluting stent demonstrated enhanced safety and efficacy in the treatment of de novo native coronary artery lesions when compared to a paclitaxel-eluting stent, and showed that "low late loss" may be achieved with drug-eluting stents without sacrificing safety.
A consistent decline in heart attack rates following the implementation of smoking bans
Strongly enforced legislation to restrict smoking produces rapid and substantial reductions in community rates of heart attack, according to a meta-analysis published today in Circulation, the journal of the American Heart Association.
Comprehensive cardiac CT scan may give clearer picture of significant heart disease
A team of researchers led by Massachusetts General Hospital (MGH) radiologists has developed a computed-tomography-based protocol that identifies both narrowing of coronary arteries and areas of myocardial ischemia - restricted blood flow to heart muscle tissue - giving a better indication of clinically significant coronary artery disease.
Two treatment innovations improve heart function after heart attack
Supersaturated oxygen (SSO2) administered during catheter-based treatments for heart attack can significantly reduce heart muscle damage, according to a new study reported in Circulation: Cardiovascular Interventions, a journal of the American Heart Association.
Oxygen-saturated blood reduces levels of damaged heart tissue following a heart attack
Results of a clinical trial published today in Circulation: Cardiovascular Interventions demonstrate that an infusion of blood that is "supersaturated" with oxygen (SS02) can reduce the amount of damaged heart muscle immediately following a life-threatening heart attack.
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