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Halting histamine action means hallelujah for hay fever sufferers
May 05, 2006In allergic diseases such as asthma, hay fever, and rhinitis an allergen stimulates the release of antibodies that attach themselves to mast cells causing these cells to release histamine, which can cause symptoms like itching of the nose, skin and eyes, sneezing, and wheezing. The characteristic "Th2 immune response" observed in allergy sufferers is an acquired immune response whose most prominent feature is high antibody production relative to the amount of cytotoxic T cells. Classical antihistamine drugs bind to but do not activate the histamine 1 receptor (H1R), subsequently blocking the allergic response. Interestingly, a recent study in Nature reported that mice deficient in H1Rs were still able to mount a Th2 immune response. In an effort to clarify this discrepancy, Paul Bryce and colleagues from Northwestern University, Chicago, examined H1R-/- mice with asthma and in their study appearing online on May 4 in advance of print publication in the June issue of the Journal of Clinical Investigation, these authors report a previously unknown role for H1R in the development of inflammatory airway responses. They found that these mice do indeed possess a dominant Th2 immune response to allergic antigens, yet they do not develop airway inflammation. Bryce et al. show that this is because the T cells in these mice are not able to travel to the site of allergen exposure - the lung. Histamine was found to act as an attractant for T cells and with no H1Rs present for histamine to bind to, the T cells were not recruited to the lung or able to cause the characteristic inflammatory allergic response in these mice. This advancement of our understanding of the roles of histamine in allergic disease indicates that blocking H1R with currently available drugs might have potential benefit for patients.
Journal of Clinical Investigation
Histamine Current Events and Histamine News RSSSublingual immunotherapy for inhalant allergies deserves deeper consideration
Sublingual immunotherapy for the treatment of allergy symptoms caused by a wide variety of environmental inhalants has been effectively used in Europe.
Aminoguanidine: An attractive line as a multi-modal avenue to overcome tumor
Aminoguanidine is a compound that exerts multiple biological actions. Aminoguanidine has well described antioxidant properties and is also an inhibitor of nitric oxide synthases, the enzymes that produce nitric oxide.
Scientists mine drugs database for new diabetes treatment
Scientists funded by the Biotechnology and Biological Sciences Research Council have harnessed a new drug discovery tool to identify a new player in the body's insulin secretion process. This finding could spark a completely new class of drugs to treat type 2 diabetes.
Canadian scientist mines drugs database for new diabetes treatment
A Canadian scientist, now based in the UK and funded by the UK Biotechnology and Biological Sciences Research Council, has harnessed a new drug discovery tool to identify a new player in the body's insulin secretion process. This finding could spark a completely new class of drugs to treat type 2 diabetes.
Of Mice and Peanuts: A new mouse model for peanut allergy
Chicago researchers report the development of a new mouse model for food allergy that mimics symptoms generated during a human allergic reaction to peanuts.
In mice, anxiety is linked to immune system
In the first study ever to genetically link the immune system to normal behavior, scientists at Rockefeller and Columbia universities show that mast cells, known as the pharmacologic bombshells of the immune system, directly influence how mice respond to stressful situations.
AGA releases evidence-based GERD guidelines
Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal conditions seen in GI and primary care clinics, however physicians who treat the disease primarily rely on empirical trials of medications and their own observations and experience to manage their patients.
Hayfever hope
With the peak grass pollen season approaching, scientists can reveal that a daily dose of probiotic can change the immune status of people with hay fever.
Study helps explain how allergic reactions are triggered
In demonstrating that a group of calcium ion channels play a crucial role in triggering inflammatory responses, researchers at Beth Israel Deaconess Medical Center (BIDMC) have not only solved a longstanding molecular mystery regarding the onset of asthma and allergy symptoms, but have also provided a fundamental discovery regarding the functioning of mast cells.
Protein a possible key to allergy and asthma control
Activating a protein found on some immune cells seems to halt the cells' typical job of spewing out substances that launch allergic reactions, a study by Johns Hopkins researchers suggests. The findings could eventually lead to new treatments for allergic reactions ranging from annoying bouts of hay fever to deadly asthma attacks.
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Histamine Take Care - 30 - Lozenge by New Chapter Histamine Take CareTM 100% Herbal Respiratory Support* Helps to balance natural histamine levels* DARTvisionTM fingerprinted extract with targeted dose-reliable bioactives Non-drowsy Nettle (Urtica dioica) has been used to promote upper respiratory health for thousands of years dating back to Ancient Greece. New Chapter® is proud to offer this revered botanical in Histamine Take Care an herbal therapeutic that helps to balance natural histamine levels and maintain open nasal passages.* New Chapter believes in the infinite wisdom of Nature and that the whole herb and its family of chemistries, and not just a small fraction of its chemical components, deliver Natures true wisdom. This belief in the whole herb represents the foundation of our formulation... |
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The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders by Divya Vohora (Editor) Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering... |
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Solaray - Histamine Blend Sp-33, 100 capsules by Solaray |
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Histamine in Normal and Cancer Cell Proliferation by M. Garcia-Caballero (Author), L. J. Brandes (Author), S. Hosoda (Editor) This volume in the series "Advances in the Biosciences" provides a review of the role of histamine in normal and cancer cell proliferation and summarizes the research carried out in this field over the last 40 years. Regarding the involvement of histamine in normal cell proliferation, the book describes, for the first time, its role in intestinal adaptation after massive bowel resection. The reader will find a definition of a new histamine receptor which explains the role of intracellular histamine in cancer development. Furthermore, this work deals with the recently recognized condition of histamine producing endocrine tumours. A chapter is devoted to the clinical application of certain histamine metabolytes as tumour markers. The book also presents the latest results of several clinical... | |
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New Chapter HISTAMINE TC 30 by New Chapter Nettle (Urtica dioica) has been used to promote upper respiratory health for thousands of years dating back to Ancient Greece. New Chapter(r) is proud to offer this revered botanical in Histamine Take Care an herbal therapeutic that helps to balance natural histamine levels and maintain open nasal passages.* New Chapter believes in the infinite wisdom of Nature and that the whole herb and its family of chemistries, and not just a small fraction of its chemical components, deliver Nature's true wisdom. This belief in the whole herb represents the foundation of our formulation philosophy for all herbal therapeutics. While many conventional extracts of Nettle are available, they don't consistently provide the broad spectrum of herbal chemistries and key bioactives available in Histamine... |
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Perseus Americanus by Histamine Apocalypse | |
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Natural Allergiclear Formula - Maintain Histamine Levels in the Normal Range for Respiratory Health - Buy Two Get One Free by Native Remedies What is AllergiClear? AllergiClear is a 100% natural remedy developed by experts in the field of natural health and especially formulated to support a healthy immune system as well as respiratory and skin health. AllergiClear is a compound remedy containing herbal and nutritional ingredients known for their positive effect in maintaining histamine levels within the normal range and supporting clear eyes, noses, sinuses and healthy problem free skin. Taken regularly, AllergiClear can make all the difference and help you to enjoy the outdoors once again! |
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The Way the World Works Is Dumb Histamine Apocalypse (Primary Contributor) |
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Metabolic Maintenance L-Methionine, 500 mg - 100 Capsules by Metabolic Maintenance L-Methionine is an important antioxidant which is beneficial in detoxification. L-Methionine helps allergy patients by removing excess histamine and may also help remove heavy metals from the body.* L-Methionine may inhibit homocysteine production, thus providing protection against the negative effects of this detrimental amino acid.* |
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Cimetidine: Proceedings of an International Symposium on Histamine H2-Receptor Antagonists, 10th-11th November, 1977, Göttingen, Federal Republic of Germany (International congress series) by W. Creutzfeldt (Editor) |
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