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UCLA researchers discover how drug binds to neurons to stop drunken symptoms of alcohol
May 09, 2006FINDINGS: UCLA researchers discovered how an experimental drug, called Ro15-4513, binds to specific receptors on brain neurons, which helps explain how this drug stops the drunken behavioral symptoms of alcohol such as impaired motor coordination, memory loss and drowsiness.
The team showed in the lab that Ro15-4513 binds to and blocks alcohol action on these highly alcohol-sensitive receptors. The UCLA group previously found that these receptors are specific subtypes of Gamma-amino butyric acid (GABA-A) receptors that play a role in impairing motor coordination caused by alcohol in experimental animals.
IMPACT: These studies are the first to show how the alcohol antidote drug Ro15-4513 binds to these GABA-A receptors. The research may lead to a better understanding of how alcohol works in the brain as well as help develop drugs that prevent alcohol actions such as a sober-up pill, and alcohol addiction medications and treatments. UCLA researchers also suggest in the future that it may be possible to harness the beneficial effects of alcohol on the body, including inducing sleep, enhancing mood or mirroring the positive effects of moderate alcohol consumption on the heart and brain.
University of California-Los Angeles
University of California-Los Angeles
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Driving Fatalities Surge on US Presidential Election Days
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Adolescent insomnia linked to depression and substance abuse during adolescence and young adulthood
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Drinking alcohol before 15 years of age is risky for later alcohol problems
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Gene variant boosts risk of fatty liver disease, scientists discover
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Bio-imaging mass spectrometry techniques reveal molecular details about complex systems
Understanding biology at the systems level is difficult, especially when studying complex specimens like tissue slices or communities of organisms in a biofilm. Scientists must be able to identify, quantify and locate the molecules present in the samples.
Working environment is 1 cause of rheumatoid arthritis
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Caffeine experts at Johns Hopkins call for warning labels for energy drinks
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