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Printer Friendly Print Researchers map links between size of hippocampus and progression to Alzheimer's dementia

Researchers map links between size of hippocampus and progression to Alzheimer's dementia

May 09, 2006

FINDINGS: UCLA researchers sought to test the theory that the hippocampus - the area of the brain that processes memory - is smaller in patients with mild cognitive impairment who develop into Alzheimer's dementia, and that it is larger in patients with mild cognitive impairment who experience cognitive stability or improvement. Using novel 3-D mapping techniques to analyze MRI (magnetic resonance imaging) data from 20 patients with mild cognitive impairment, they found that the patients with the smaller hippocampus did, in fact, face an increased risk of developing dementia.

IMPACT: The technique helps physicians detect subtle anatomical differences and can be applied to any disease affecting the hippocampus such as other forms of dementia, epilepsy, hippocampal sclerosis, etc. Tools such as this for predicting cognitive decline hold great promise for patient counseling, advanced planning and therapeutic decision-making.





University of California-Los Angeles



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