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Do testosterone patches help women with under-active pituitary glands?
May 10, 2006New research published today in The Journal of Clinical Endocrinology & Metabolism showed the first positive effect of testosterone on bone density, body composition and emotional, cognitive and behavioral function in women with low testosterone levels resulting from under-active pituitary glands.
Loss of ovarian and/or adrenal function can cause many women to experience hypopituitarism or under-active pituitary glands, and therefore low levels of testosterone, which is responsible for producing estrogen. This lack of testosterone can be blamed for loss of sex drive, loss of muscle tone and decrease of cognitive sharpness.
Researchers, led by Karen K. Miller, M.D., wanted to determine whether using physiological testosterone replacement in the form of dermal patches would improve (1) bone density, (2) body composition and (3) neuro-behavioral function in these women with low testosterone levels resulting from hypopituitarism.
Fifty-one women of reproductive age with low testosterone levels from hypopituitarism participated in this 12-month study by wearing a testosterone-administering patch that delivered 300 mcg daily or a placebo. Researchers analyzed bone density, fat-free mass and fat mass, as well as thigh muscle and abdominal area. Mood, sexual function, quality of life and cognitive function were assessed by questionnaire.
Results demonstrated an encouraging effect, with few side effects, and may prove to be useful in the clinical setting for women with low testosterone levels resulting from under-active pituitary glands.
The Endocrine Society & The Hormone Foundation
Fifty-one women of reproductive age with low testosterone levels from hypopituitarism participated in this 12-month study by wearing a testosterone-administering patch that delivered 300 mcg daily or a placebo. Researchers analyzed bone density, fat-free mass and fat mass, as well as thigh muscle and abdominal area. Mood, sexual function, quality of life and cognitive function were assessed by questionnaire.
Results demonstrated an encouraging effect, with few side effects, and may prove to be useful in the clinical setting for women with low testosterone levels resulting from under-active pituitary glands.
The Endocrine Society & The Hormone Foundation
Testosterone Current Events and Testosterone News RSSHeart and bone damage from low vitamin D tied to declines in sex hormones
Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
Pilot study relates phthalate exposure to less-masculine play by boys
A study of 145 preschool children reports, for the first time, that when the concentrations of two common phthalates in mothers' prenatal urine are elevated their sons are less likely to play with male-typical toys and games, such as trucks and play fighting.
Hormone that affects finger length key to social behavior
The hormones, called androgens, are important in the development of masculine characteristics such as aggression and strength.
Postmenopausal women with higher testosterone levels
Postmenopausal women who have higher testosterone levels may be at greater risk of heart disease, insulin resistance and the metabolic syndrome compared to women with lower testosterone levels.
Fetal study highlights impact of stress on male fertility
Exposure to a combination of excess stress hormones and chemicals while in the womb could affect a man's fertility in later life, a study suggests.
Studies examine how living conditions impact reproductive health
When costs outweigh benefits, successful pregnancies are less likely to occur. Life is all about tradeoffs and recently published research by Virginia J. Vitzthum, a senior scientist at Indiana University's Kinsey Institute for Research in Sex, Gender, and Reproduction, and professor in the IU College of Arts and Sciences' Department of Anthropology, has shown that during periods of intense labor and low food intake, rates of early pregnancy loss can more than double.
BUSM researchers propose a relationship between androgen deficiency and cardiovascular disease
Researchers from Boston University School of Medicine (BUSM) in collaboration with researchers from Lahey Clinic Northshore, Peabody, Mass., believe that androgen deficiency might be the underlying cause for a variety of common clinical conditions, including diabetes, erectile dysfunction, metabolic syndrome and cardiovascular disease (CVD).
Prostate cancer patients on hormone therapy at increased risk for various heart diseases
New research has found that hormone therapy used to treat men with advanced prostate cancer is associated with an increased chance of developing various heart problems. Some choices of therapy appear, however, to be less risky than others.
Obesity increases risk of prostate cancer recurrence for both blacks and whites
A new look at a large database of prostate cancer patients shows that obesity plays no favorites when it comes to increasing the risk of recurrence after surgery: Being way overweight is equally bad for blacks and whites, say researchers at Duke University Medical Center.
Life and death in the living brain
Like clockwork, brain regions in many songbird species expand and shrink seasonally in response to hormones. Now, for the first time, University of Washington neurobiologists have interrupted this natural "annual remodeling" of the brain and have shown that there is a direct link between the death of old neurons and their replacement by newly born ones in a living vertebrate.
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