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Modeling head and neck cancers
May 15, 2006In a report to be published in the May 15th issue of G&D, Dr. Xiao-Jing Wang and colleagues at Oregon Health & Science University present a novel model of head and neck cancer, which is expected to become an invaluable tool in the evaluation of biomarkers and therapies to treat this devastating disease.
Squamous cell carcinoma of the head and neck (or head and neck squamous cell carcinoma, or HNSCC, as it is known) is a malignant tumor of epithelial origin, which accounts for 90% of all head and neck cancers. While scientists have identified some genes involved in HNSCC, overall, progress has been hampered by the lack of an animal model to study the development and progression of the disease.
Dr. Wang and colleagues have succeeded in creating the first completely penetrant animal model of HNSCC. They engineered a strain of mice to specifically lack expression of the transforming growth factor beta receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either H-ras or K-ras (two different isoforms of the Ras GTPase), the researchers were able to induce invasive HNSCC with 100% incidence.
The TGFbRII-ablation mouse model recapitulates the human disease, both at the pathological and molecular levels. "Since these mouse HNSCC lesions exhibited multiple molecular alterations that most commonly occur in human HNSCC, this mouse model provides a unique tool for testing combinations of targeted therapies for HNSCC. In addition, the predictable kinetics of tumor formation in these mice will make this model ideal to test prevention approaches for HNSCC," explains Dr. Wang.
Cold Spring Harbor Laboratory
The TGFbRII-ablation mouse model recapitulates the human disease, both at the pathological and molecular levels. "Since these mouse HNSCC lesions exhibited multiple molecular alterations that most commonly occur in human HNSCC, this mouse model provides a unique tool for testing combinations of targeted therapies for HNSCC. In addition, the predictable kinetics of tumor formation in these mice will make this model ideal to test prevention approaches for HNSCC," explains Dr. Wang.
Cold Spring Harbor Laboratory
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New diagnostic advance seen for head, throat cancer
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Survey shows Americans may be missing direct route to head and neck cancer care
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Researchers identify genetic markers for aggressive head and neck cancer
Scientists at Albert Einstein College of Medicine of Yeshiva University have identified genetic markers that signal poor outcomes for patients with head and neck cancer. These findings could one day lead to a genetic test that could help select or predict successful treatment options for patients with this type of cancer. The results were published in the American Journal of Pathology.
Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening
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Head and Neck Cancer Awareness Ribbon Mouse Pad by MyHeritageWear.com The Head and Neck Cancer Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Head and Neck Cancer Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Head and Neck Cancer Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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Radiotherapy For Head And Neck Cancers Indications And Techniques by Lippincott Williams & Wilkins Radiotherapy for Head and Neck Cancers Indications and Techniques : Radiotherapy for Head and Neck Cancers Indications and Techniques Pub Date: October 2005 Product Type: Print Author/s: K. K Ang MD, PhD; Adam S Garden MD Long established as a staple reference for all radiation oncologists, Radiotherapy for Head and Neck Cancers: Indications and Techniques is now in its Third Edition. This completely updated edition presents the state-of-the-art protocols currently used at the M.D. Anderson Cancer Center and thoroughly explains the principles, nomenclature, and clinical use of intensity-modulated radiotherapy (IMRT). New full-color illustrations have been added throughout the book.The first section discusses the practical aspects of external beam therapy,... |
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Meeting the Challenges of Oral and Head and Neck Cancer: A Survivor's Guide by Nancy E. Leupold (Author), James J. Sciubba (Author), Nancy E. Leupold (Editor), James J. Sciubba (Editor) Nancy Leupold, herself a survivor, and president and founder of Support for People with Oral and Head and Neck Cancer (SPOHNC), and James J. Sciubba present an overview of the different disciplines involved in the treatment of oral and head and neck cancer, with emphasis on providing information and survivor tips to help survivors cope with the disease, its treatment, and their consequential side effects. This book takes a deliberately different stance and approach from other survivor guides, in that it concentrates on helping the individual who has completed treatment and is now on the road to recovery. Furthermore, it is unique in that it is attempting to meet the challenges of oral and head and neck cancer with specific information, in the form of lists and tables of products and... |
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Head And Neck Cancer A Multidisciplinary Approach by Lippincott Williams & Wilkins Head and Neck Cancer A Multidisciplinary Approach : Head and Neck Cancer A Multidisciplinary Approach Pub Date: September 2008 Product Type: Print Author/s: Louis B Harrison MD; Roy B Sessions MD; Waun K Hong MD This comprehensive, multidisciplinary text addresses all aspects of head and neck cancer and represents a wide spectrum of specialists, including surgical, radiation, and medical oncologists, dentists, pathologists, radiologists, and nurses. The book focuses on a two-part approach to treatment that maximizes the chance for a cure while maintaining a strong emphasis on quality of life.This Third Edition's updated techniques section includes new radiation techniques such as IMRT and IGRT and new endoscopic and laser surgical techniques. Other highlights include... |
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