 |
|
Location, location, location: Transcriptional activity and nuclear position
May 18, 2006Dr. Mark Groudine (FHCRC) and colleagues report on their surprising characterization of changes in intranuclear organization during murine erythropoiesis. By assaying the nuclear position and expression level of the beta globin locus during various stages of erythropoiesis, the researchers found that beta globin expression begins at the nuclear periphery, and as red blood cells mature, the beta globin locus progressively moves away from the nuclear periphery, towards the interior. Furthermore, they found that efficient relocalization is dependent upon the locus control region (LCR). Contrary to the existing dogma, this finding demonstrates that gene transcription precedes relocalization - establishing the nuclear periphery as the new hot spot. Dr. Groudine emphasizes that "As recently shown in yeast, the nuclear periphery is a more complex compartment than thought. Clearly, determining the protein complexes associated with gene activation and repression at the nuclear periphery in mammalian cells is a high priority."
Cold Spring Harbor Laboratory
Location matters, even for genes
Moving an active gene from the interior of the nucleus to its periphery can inactivate that gene report scientists from the University of Chicago Medical Center in an article to be published early online Feb.13, 2008, in the journal Nature.
NYU biologists identify gene that coordinates two cellular processes
A team of biologists at New York University's Center for Comparative Functional Genomics has uncovered a dual role for the gene mel-28. The gene plays a part in ensuring that chromosomes are divided properly during cell division and it is required for nuclear envelope function.
Movement of chromosome in nucleus visualized
The cell is understood to be highly organized, with specialized areas for different functions and molecular motors shuttling components around.
More Nuclear Periphery Current Events and Nuclear Periphery News Articles
| © 2009 BrightSurf.com |