 |
|
Injecting stem cells from a woman's own muscle may effectively treat urinary incontinence
May 22, 2006In the first clinical study of its kind in North America, women with stress urinary incontinence (SUI) were treated using muscle-derived stem cell injections to strengthen deficient sphincter muscles responsible for the condition. Results of the study, led by researchers at the University of Pittsburgh School of Medicine and Sunnybrook Health Sciences Centre in Toronto, suggest that the approach is safe, improves patients' quality of life and may be an effective treatment for SUI. The findings will be presented at an experts' session at the annual meeting of the American Urological Association (AUA) in Atlanta, and will be published in abstract 1185 in the AUA proceedings.
"The technique to achieve optimal efficacy is evolving, but we are pleased with what this study has shown," said principal investigator Lesley Carr, M.D., urologist at Sunnybrook Health Sciences Centre and assistant professor at the University of Toronto. "We now have preliminary evidence that stem cells are safe to use and appear to improve female stress urinary incontinence."
Previous studies at the University of Pittsburgh School of Medicine in animal models with SUI demonstrated that injecting stem cells into the urethral muscles increases leak point pressure, leading to a restoration of the deficient muscles. The results of these studies formed the basis for the clinical trial.
"Our preliminary findings in this clinical trial are extremely encouraging, given that 13 million people, most of them women, cope with stress urinary incontinence in the United States," said Michael B. Chancellor, M.D., the study's senior author and professor of urology and gynecology at the University of Pittsburgh School of Medicine. "We're demonstrating for the first time that we may be able to offer people with SUI a long-term and minimally invasive treatment."
In the study, researchers took biopsies of skeletal muscle tissue from seven female patients and isolated and expanded the stem cells from the tissue in culture. In an outpatient setting, the patients then received injections of the muscle-derived stem cells into the area surrounding the urethra. Each patient received an equal dose of stem cell injections using three different injection techniques - a transurethral injection with either an 8-mm or 10-mm needle or a periurethral injection.
Five of the seven women who participated in the study reported improvement in bladder control and quality of life with no serious short- or long-term adverse effects. These improvements were associated with both the 10-mm needle injections and the periurethral injections, which allowed the investigators to deliver the stem cells close to the damaged sphincter muscle. The 8-mm needle was not able to deliver the muscle stem cells deep enough into the tissue to reach the sphincter.
A follow-up multi-site study set to launch this summer will allow researchers to determine the optimal dose of muscle stem cells needed to effectively treat SUI.
Women with SUI involuntarily lose urine during activities that put pressure on the bladder, such as running, coughing, sneezing or laughing. Stress incontinence is caused by childbirth, menopause or pelvic surgery and is most often diagnosed in women during middle-age.
Sunnybrook Health Sciences Centre
"Our preliminary findings in this clinical trial are extremely encouraging, given that 13 million people, most of them women, cope with stress urinary incontinence in the United States," said Michael B. Chancellor, M.D., the study's senior author and professor of urology and gynecology at the University of Pittsburgh School of Medicine. "We're demonstrating for the first time that we may be able to offer people with SUI a long-term and minimally invasive treatment."
In the study, researchers took biopsies of skeletal muscle tissue from seven female patients and isolated and expanded the stem cells from the tissue in culture. In an outpatient setting, the patients then received injections of the muscle-derived stem cells into the area surrounding the urethra. Each patient received an equal dose of stem cell injections using three different injection techniques - a transurethral injection with either an 8-mm or 10-mm needle or a periurethral injection.
Five of the seven women who participated in the study reported improvement in bladder control and quality of life with no serious short- or long-term adverse effects. These improvements were associated with both the 10-mm needle injections and the periurethral injections, which allowed the investigators to deliver the stem cells close to the damaged sphincter muscle. The 8-mm needle was not able to deliver the muscle stem cells deep enough into the tissue to reach the sphincter.
A follow-up multi-site study set to launch this summer will allow researchers to determine the optimal dose of muscle stem cells needed to effectively treat SUI.
Women with SUI involuntarily lose urine during activities that put pressure on the bladder, such as running, coughing, sneezing or laughing. Stress incontinence is caused by childbirth, menopause or pelvic surgery and is most often diagnosed in women during middle-age.
Sunnybrook Health Sciences Centre
Urinary Incontinence Current Events and Urinary Incontinence News RSSOHSU Cancer Institute researchers study breathing during radiation
Oregon Health & Science University researchers have determined exactly how much breathing affects prostate movement during radiation treatment.
Pelvic disorders affect large number of women, UT Southwestern researchers find
Nearly one-quarter of all women suffer from pelvic-floor disorders, such as incontinence, at some point in their lives, a national study, including researchers from UT Southwestern Medical Center, has found.
Urologists report success using robot-assisted surgery for urinary abnormality
Ashok Hemal, M.D., a urologic surgeon from Wake Forest University Baptist Medical Center, and colleagues have reported success using robot-assisted laparoscopic surgery to repair abnormal openings between the bladder and vagina known as fistulas.
Dual treatment of incontinence and dementia associated with functional decline
Older nursing home residents who took medications for dementia and incontinence at the same time had a 50 percent faster decline in function than those who were being treated only for dementia, according to a study from researchers at Wake Forest University School of Medicine and colleagues.
Black women have urinary incontinence less than half as often as white women
The good news for black women: They have less than half the chance of developing urinary incontinence as do white women, according to a new study from the University of Michigan Health System.
Prostate size and other neglected factors influence prostate cancer treatment satisfaction
Men with prostate cancer and their partners face difficult decisions regarding treatment, and accurate information regarding expected outcomes can be hard to find, according to results of a multi-center study published Wednesday in the New England Journal of Medicine.
Congestive heart failure leads to greater disability, nursing home admissions
Medical breakthroughs in recent decades have allowed heart attack survivors and other heart-disease patients to live longer. But as their hearts decline into congestive heart failure, an increasing number will experience disability and the need for nursing-home care.
NIH State-of-the-Science Panel Seeks to Dispel Stigma Associated With Fecal and Urinary Incontinence
An independent panel convened this week by the NIH found that fewer than half of individuals experiencing fecal or urinary incontinence - the inability to control bowel movements or urination, respectively - report their symptoms to healthcare providers without being prompted.
'Mismatched' prostate cancer treatment more common than expected
More than a third of men with early prostate cancer who participated in a study analyzing treatment choice received therapies that might not be appropriate, based on pre-existing problems with urinary, bowel or sexual function.
Removal of uterus increases risk of urinary incontinence
Researchers at the Swedish medical university Karolinska Institutet have shown that hysterectomy - a common operation involving the removal of the uterus - greatly increases the risk of urinary incontinence.
More Urinary Incontinence Current Events and Urinary Incontinence News Articles
 | Managing and Treating Urinary Incontinence by Diane Kaschak Newman After reading "Managing and Treating Urinary Incontinence," you will be armed with all the available methods for successfully managing or even eliminating incontinence methods far more diverse and effective than many professionals today are aware.In pragmatic, easy-to-understand language, this book presents the full range of treatment options, explaining how each method works and who benefits... |
 | Urinary & Fecal Incontinence: Current Management Concepts by Dorothy B. Doughty Completely updated to reflect current practice, the 3rd edition of this comprehensive resource provides a multi-disciplinary, in-depth review of the physiology of continence, the pathologic mechanisms producing incontinence, and current treatment options for the various types of incontinence. Assessment, behavioral therapies, and multidisciplinary care are emphasized as key elements in the... |
 | The Official Patient's Sourcebook on Male Urinary Incontinence: A Revised And Updated Directory for the Internet Age by Icon Health Publications |
 | A Woman's Guide to Urinary Incontinence (A Johns Hopkins Press Health Book) by Rene Genadry, Jacek L. Mostwin Urinary incontinence causes discomfort and distress for millions of women, particularly those who have borne children, are postmenopausal, or have passed the age of forty. This condition can have a severe negative impact on one's quality of life, and successful treatment, while possible, is complex. Cowritten by a gynecologist and a urologist who have helped thousands of frustrated women, this... |
 | Incontinence Solution by William Parker M.D., Amy Rosenman M.D. Millions of women experience difficulties controlling their bladders but suffer in silence, reluctant to speak to their doctors -- or even to their best friends -- about the problem. Here, at last, women will find the most up-to-date medical explanations and state-of-the-art solutions, including:Controversial links between current childbirthing practices -- like episiotomy, the use of forceps,... |
 | Overcoming Urinary Incontinence: A Woman's Guide to Treatment by Michael H. Safir, Clay N. Boyd, Tony E. Pinson Addressing the most commonly asked questions about incontinence, this accessible reference discusses causes, types of incontinence, and how the condition is diagnosed. The wide range of treatment options is introduced, from pelvic floor therapy and bladder training to electrical stimulation, medications, and surgeries. Eleven million women in the U.S. are coping with urinary incontinence—half... |
 | Incontinence A Time to Heal with Yoga and Acupressure: A Six Week Exercise Program for People With Simple Stress Urinary Incontinence by Dawn R. Mahowald, Emmey A. Ripoll About the Book "These exercises [for Simple Urinary Incontinence] really DO work! I use them regularly and I often remind my friends to do the same." Therese Sherry, Active Retiree, Arkansas Do you, like so many others, suffer from Simple Urinary Incontinence? Do you leak urine when you sneeze, cough, or run? Do you have trouble making it to the bathroom in time? Do you... |
 | Female Urinary Incontinence in Practice (In Practice) by Matthew Parsons, Linda Cardozo Is a comprehensive guide to the aetiology, diagnosis and treatment of this common condition. All the latest therapies are discussed in detail and it will be a useful handbook for all GPs, hospital doctors, medical students and... |
| Urinary Incontinence in Adults, Clinical Practice Guideline and A Patient's Guide by U.S. Department of Health and Human Services | |
 | Urinary & Fecal Incontinence: Nursing Management Emory Univ., Atlanta, GA. Practical text on the nursing management of incontinence. Reviews the physiology of continence, the pathologic mechanisms producing incontinence, and treatment options with emphasis on behavioral therapy. Each chapter contains objectives, summaries, self-tests and bibliographies. Previous edition:... |
| © 2008 BrightSurf.com |