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Knowledge of infection may prevent spread of herpes virus
May 31, 2006A new study suggests that the risk of transmitting the virus that causes most cases of genital herpes could be cut in half by more testing and informing sexual partners of infection. The study is published in the July 1 issue of The Journal of Infectious Diseases, now available online.
Until recently, there was little evidence to show that knowledge of infection would lead to decreased transmission of herpes simplex virus (HSV) to others. But Anna Wald, MD, MPH, and colleagues at the University of Washington and the Fred Hutchison Cancer Research Center in Seattle studied 199 patients with newly acquired genital HSV-2 infection and found that patients were about half as likely to transmit the virus when they knew they had genital herpes and informed their sexual partners.
According to Wald, "these findings suggest that testing persons with HSV type-specific serologic assays and encouraging disclosure may result in decreased risk of HSV-2 transmission to sexual partners."
The importance of this finding is described by editorialists Edward Hook III, MD, of the University of Alabama at Birmingham and Peter Leone, MD, of the University of North Carolina at Chapel Hill as one of three effective tools to prevent the spread of this sexually transmitted disease (STD). "Genital herpes is one of the few common STDs for which, at present, there is little coordinated emphasis on control efforts," say Hook and Leone. The two experts also support suppressive antiviral therapy and condom use as the other necessary elements to control the spread of genital herpes nationwide.
This most recent study also found that most people who transmitted HSV did not know that they had genital herpes. Wald, Hook, and Leone suggest that physicians should not only increase testing for HSV, but should also counsel their patients about transmitting the virus and disclosing their HSV status to sex partners.
Infectious Diseases Society of America
The importance of this finding is described by editorialists Edward Hook III, MD, of the University of Alabama at Birmingham and Peter Leone, MD, of the University of North Carolina at Chapel Hill as one of three effective tools to prevent the spread of this sexually transmitted disease (STD). "Genital herpes is one of the few common STDs for which, at present, there is little coordinated emphasis on control efforts," say Hook and Leone. The two experts also support suppressive antiviral therapy and condom use as the other necessary elements to control the spread of genital herpes nationwide.
This most recent study also found that most people who transmitted HSV did not know that they had genital herpes. Wald, Hook, and Leone suggest that physicians should not only increase testing for HSV, but should also counsel their patients about transmitting the virus and disclosing their HSV status to sex partners.
Infectious Diseases Society of America
Herpes Virus Current Events and Herpes Virus News RSSNew culprit for viral infections among elderly -- an overactive immune response
Researchers at Yale School of Medicine have found that exaggerated responses of the immune system explain why the elderly succumb to viral infections more readily than younger people.
UCSF researchers identify new drug target for Kaposi's Sarcoma
UCSF researchers have identified a new potential drug target for the herpes virus that causes Kaposi's sarcoma, re-opening the possibility of using the class of drugs called protease inhibitors against the full herpes family of viruses, which for 20 years has been deemed too difficult to attain.
Researchers testing virus-gene therapy combination against melanoma
Researchers at the Moores UCSD Cancer Center are injecting a modified herpes virus into melanoma tumors, hoping to kill the cancer cells while also bolstering the body's immune defenses against the disease.
Study indicates that a common virus could cause high blood pressure
A new study suggests for the first time that cytomegalovirus (CMV), a common viral infection affecting between 60 and 99 percent of adults worldwide, is a cause of high blood pressure, a leading risk factor for heart disease, stroke and kidney disease.
Herpes medication does not reduce risk of HIV transmission
A recently completed international multi-center clinical trial has found that acyclovir, a drug widely used as a safe and effective treatment to suppress herpes simplex virus-2 (HSV-2), which is the most common cause of genital herpes, does not reduce the risk of HIV transmission when taken by people infected with both HIV and HSV-2.
Potential new herpes therapy studied
A new therapy being developed at the University of Florida could, in time, produce another weapon for the fight against herpes.
Engineered virus targets and kills apparent cancer stem cells in neuroblastoma
After identifying an apparent population of cancer stem cells for neuroblastoma, researchers successfully used a reprogrammed herpes virus to block tumor formation in mice by targeting and killing the cells.
OHSU finds association between Epstein-Barr virus, inflammatory diseases of the mouth
Researchers at Oregon Health & Science University's School of Dentistry (www.ohsu.edu/sod) have found that a significant percentage of dental patients with the inflammatory diseases irreversible pulpitis and apical periodontitis also have the Epstein-Barr virus.
Keeping herpes infection in check: Pitt researchers describe immune system strategies
Herpes simplex virus type I can cause bouts of cold sores, blindness and potentially lethal encephalitis when it reawakens from a quiescent state in the nerve cells it infects.
U of T researchers reveal Epstein-Barr virus protein contributes to cancer
Researchers at the University of Toronto have discovered that the EBNA1 protein of Epstein-Barr virus (EBV) disrupts structures in the nucleus of nasopharyngeal carcinoma (NPC) cells, thereby interfering with cellular processes that normally prevent cancer development.
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