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New study re-evaluates cardiovascular risks of anti-inflammatory drugs
June 02, 2006Do cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials; BMJ Volume 332, pp 1302-5
High doses of some traditional non-steroidal anti-inflammatory drugs (NSAIDS) are associated with similar cardiovascular risks as the new generation of anti-inflammatory drugs known as COX 2 inhibitors (like Vioxx ®), finds a study in this week's BMJ.
Researchers from the UK and Italy performed a combined analysis (known as a "meta-analysis") of all the available randomised trials that compared a COX 2 inhibitor with placebo, or a COX 2 inhibitor with a traditional NSAID, and had recorded serious cardiovascular events. By including data from 138 trials among 140,000 patients, this meta-analysis provides a much more reliable estimate of the cardiovascular risks of these drugs, since individual trials were too small to study this question.
The study showed, as expected, that, COX 2 inhibitors were associated with an increased risk of vascular events, mainly heart attack. Unfortunately, there were insufficient data to reliably assess whether these risks were dose dependent, or whether the risks might differ among aspirin and non-aspirin users.
But the study also showed that high doses of two of the NSAIDs studied, diclofenac and ibuprofen, were associated with a similar increase in the risk of vascular events to COX 2 inhibitors, although the risks of high doses of another NSAID, naproxen, were smaller.
However, the average increased risk of vascular events was modest among the people studied in the trials: For every 1,000 people taking an NSAID or COX 2 inhibitor, around three extra people per year would have a vascular event, most likely a heart attack.
The authors conclude that very large randomised trials are needed to identify which anti-inflammatory drug regimens minimise serious cardiovascular and gastrointestinal problems.
An accompanying editorial discusses other options for treating chronic pain and suggests that doctors work with their patients to choose the best solutions for them.
BMJ-British Medical Journal
But the study also showed that high doses of two of the NSAIDs studied, diclofenac and ibuprofen, were associated with a similar increase in the risk of vascular events to COX 2 inhibitors, although the risks of high doses of another NSAID, naproxen, were smaller.
However, the average increased risk of vascular events was modest among the people studied in the trials: For every 1,000 people taking an NSAID or COX 2 inhibitor, around three extra people per year would have a vascular event, most likely a heart attack.
The authors conclude that very large randomised trials are needed to identify which anti-inflammatory drug regimens minimise serious cardiovascular and gastrointestinal problems.
An accompanying editorial discusses other options for treating chronic pain and suggests that doctors work with their patients to choose the best solutions for them.
BMJ-British Medical Journal
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Clinical Applications Of Antibiotics And Anti-inflammatory Drugs In Ophthalmology Co-published By Jaypee Brothers And Lippincott Williams & Wilkins by Lippincott Williams & Wilkins Clinical Applications of Antibiotics and Anti-Inflammatory Drugs in Ophthalmology Co-Published by Jaypee Brothers and Lippincott Williams & Wilkins : Clinical Applications of Antibiotics and Anti-Inflammatory Drugs in Ophthalmology Co-Published by Jaypee Brothers and Lippincott Williams & Wilkins Pub Date: October 2007 Product Type: Print Author/s: Ashok Garg MS, PhD, FIAO (Bel), FRSM, ADM, FAIMS, FICA; John D Sheppard MD, MMSc; Eric D Donnenfeld MD, FCA; Mitchell Friedlaender MD Written by an international group of experts, this book is a complete, current guide to antibiotic and anti-inflammatory pharmacotherapy in ophthalmology and ocular surgery. Coverage includes up-to-date information on new generation fluoroquinolones, new uses of tetracyclines, topical... |
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CRYPTOME GETS OPTION FOR ANTI-INFLAMMATORY DRUG LICENSE.: An article from: Worldwide Biotech by Worldwide Videotex (Publisher) This digital document is an article from Worldwide Biotech, published by Worldwide Videotex on April 1, 2005. The length of the article is 686 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: CRYPTOME GETS OPTION FOR ANTI-INFLAMMATORY DRUG LICENSE. Publication: Worldwide Biotech (Newsletter) Date: April 1, 2005 Publisher: Worldwide Videotex Volume: 17 Issue: 4 Page: NA Distributed by Thomson Gale | |
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Clinical Applications of Antibiotics and Anti-Inflammatory Drugs in Ophthalmology: Co-Published by Jaypee Brothers and Lippincott Williams & Wilkins by Ashok Garg (Editor), John D Sheppard (Editor), Eric D Donnenfeld (Editor), Mitchell Friedlaender (Editor) Written by an international group of experts, this book is a complete, current guide to antibiotic and anti-inflammatory pharmacotherapy in ophthalmology and ocular surgery. Coverage includes up-to-date information on new generation fluoroquinolones, new uses of tetracyclines, topical azithromycin, new anti-inflammatory drugs, endophthalmitis prophylaxis and management, and treatment of corneal ulcers, uveitis, cystoid macular edema, blepharitis, and post-refractive keratitis. Close attention is given to preoperative and postoperative antibiotic prophylaxis and nonsteroidal anti-inflammatory therapy to optimize outcomes in cataract and refractive surgeries. A section on recent advances includes toxic anterior segment syndrome, topical immune therapy, and nanotechnology. A bound-in... |
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