 |
|
Gene therapy accelerates healing of damaged skeletal muscle
June 05, 2006University of Pittsburgh School of Medicine researchers have successfully used gene therapy to accelerate muscle regeneration in experimental animals with muscle damage, suggesting this technique may be a novel and effective approach for improving skeletal muscle healing, particularly for serious sports-related injuries. These findings are being presented at the American Society of Gene Therapy annual meeting in Baltimore, May 31 to June 4.
Skeletal muscle injuries are the most common injuries encountered in sports medicine. Although such injuries can heal spontaneously, scar tissue formation, or fibrosis, can significantly impede this process, resulting in incomplete functional recovery. Of particular concern are top athletes, who, when injured, need to recover fully as quickly as possible.
In this study, the Pitt researchers injected mice with a gene therapy vector containing myostatin propeptide—a protein that blocks the activity of the muscle-growth inhibitor myostatin—three weeks prior to experimentally damaging the mice's skeletal muscles. Four weeks after skeletal muscle injury, the investigators observed an enhancement of muscle regeneration in the gene-therapy treated mice compared to the non-gene-therapy treated control mice. There also was significantly less fibrous scar tissue in the skeletal muscle of the gene-therapy treated mice compared to the control mice.
According to corresponding author Johnny Huard, Ph.D., the Henry J. Mankin Endowed Chair and Professor in Orthopaedic Surgery, University of Pittsburgh School of Medicine, and Director of the Stem Cell Research Center of Children's Hospital of Pittsburgh, this approach offers a significant, long-lasting method for treating serious, sports-related muscle injuries.
"Based on our previous studies, we expect that gene-therapy treated cells will continue to overproduce myostatin propeptide for at least two years. Since the remodeling phase of skeletal muscle healing is a long-term process, we believe that prolonged expression of myostatin propeptide will continue to contribute to recovery of injured skeletal muscle by inducing an increase in muscle mass and minimizing fibrosis. This could significantly reduce the amount of time an athlete needs to recover and result in a more complete recovery," he explained.
University of Pittsburgh Medical Center
According to corresponding author Johnny Huard, Ph.D., the Henry J. Mankin Endowed Chair and Professor in Orthopaedic Surgery, University of Pittsburgh School of Medicine, and Director of the Stem Cell Research Center of Children's Hospital of Pittsburgh, this approach offers a significant, long-lasting method for treating serious, sports-related muscle injuries.
"Based on our previous studies, we expect that gene-therapy treated cells will continue to overproduce myostatin propeptide for at least two years. Since the remodeling phase of skeletal muscle healing is a long-term process, we believe that prolonged expression of myostatin propeptide will continue to contribute to recovery of injured skeletal muscle by inducing an increase in muscle mass and minimizing fibrosis. This could significantly reduce the amount of time an athlete needs to recover and result in a more complete recovery," he explained.
University of Pittsburgh Medical Center
Skeletal Muscle Current Events and Skeletal Muscle News RSSHigh-fat diet impairs muscle health before impacting function
Skeletal muscle plays a critical role in regulating blood sugar levels in the body. But few studies have comprehensively examined how obesity caused by a high-fat diet affects the health of muscle in adolescents who are pre-diabetic.
Scientists discover new genetic variation that contributes to diabetes
Scientists have identified a genetic variation in people with type 2 diabetes that affects how the body's muscle cells respond to the hormone insulin, in a new study published today in Nature Genetics. The researchers, from Imperial College London and other international institutions, say the findings highlight a new target for scientists developing treatments for diabetes.
Carnitine supplements reverse glucose intolerance in animals
Supplementing obese rats with the nutrient carnitine helps the animals to clear the extra sugar in their blood, something they had trouble doing on their own, researchers at Duke University Medical Center report.
Mutation responsible for cystic fibrosis also involved in muscle atrophy
Patients with cystic fibrosis (CF) usually experience significant muscle loss, a symptom traditionally considered to be a secondary complication of the devastating genetic disease.
Injection reverses heart-attack damage
Injured heart tissue normally can't regrow, but researchers at Children's Hospital Boston have now laid the groundwork for regenerating heart tissue after a heart attack, in patients with heart failure, or in children with congenital heart defects.
Researchers make progress toward early identification of muscular dystrophy
The saying "Knowing is half the battle" is never more true than when discussing early treatment of disease. Muscular dystrophy is one such disease where patients can benefit from early treatment. Now, new research is moving doctors and scientists closer to disease diagnosis in advance of patient symptoms.
Muscle atrophy through thick but not thin
During desperate times, such as fasting, or muscle wasting that afflicts cancer or AIDS patients, the body cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids.
Study further expands understanding of leptin's role in brain neurocircuitry
In investigating the complex neurocircuitry behind weight gain and glucose control, scientists have known that the hormone leptin plays a key role in the process.
Adult Bone Marrow Stem Cells Injected into Skeletal Muscle Can Repair Heart Tissue
University at Buffalo researchers have demonstrated for the first time that injecting adult bone marrow stem cells into skeletal muscle can repair cardiac tissue, reversing heart failure.
Heart saves muscle
A heart muscle protein can replace its missing skeletal muscle counterpart to give mice with myopathy a long and active life.
More Skeletal Muscle Current Events and Skeletal Muscle News Articles
 |
Skeletal Muscle: Form and Function - 2nd Edition by Brian MacIntosh (Author), Phillip Gardiner (Author), Alan McComas (Author) Skeletal Muscle: Form and Function, Second Edition, provides readers with a detailed understanding of the different facets of muscle physiology. Meticulously researched and updated, this text examines motoneuron and muscle structure and function. It is intended for those who need to know about skeletal muscle—from undergraduate and graduate students gaining advanced knowledge in kinesiology to physiotherapists, physiatrists, and other professionals whose work demands understanding of muscle form and function. A unique feature of this book is that it combines basic sciences (anatomy, physiology, biophysics, and chemistry) with clinical applications (detection of disease and genetic mutations and training and rehabilitation). Each chapter ends with a section on clinical and other... |
 |
Skeletal System - Bones, Muscles and Blood Support by HoneyCombs Think calcium is only beneficial for the bones? Consider that it also helps regulate the heartbeat and builds and maintains healthy teeth, muscles and blood. Calcium deficiency is associated with many illnesses and diseases besides osteoporosis. The Skeletal System supplies the body with the necessary calcium it needs along with other nutrients to strengthen the skeletal system and fight off diseases. Approx: one month supply. |
 |
Skeletal Muscle Damage and Repair:Mechanisms & Interventions by Peter Tiidus (Author) Professionals and students interested in understanding the physiological mechanisms of skeletal muscle damage and repair will welcome this uniquely comprehensive text. Presenting both research-based information and applied clinical topics, Skeletal Muscle Damage and Repair assists readers in understanding the interrelationships of basic physiology, specific populations, and practical treatments for muscle injury and damage. The text covers a broad spectrum of topics: The basic science and scientific methods used to investigate exercise-related muscle damage and repair A review of current research related to the mechanisms of muscle damage, physiological responses to damage, and subsequent methods of muscle repair An examination of issues specific to various populations, including the... |
|
EXERCISE & INTRACELLULAR REGULATION OF CARDIAC & SKELETAL MUSCLE by SportsWorkout.com This book examines the effects of acute and chronic exercise on the metabolism of cyclic AMP and protein kinase in cardiac and skeletal muscle. Written by four of the world leaders in this emerging area of exercise biochemistry, Exercise and Intra | |
 |
Major Skeletal Muscles and Their Actions DVD by United Learning "Produced by Western Wisconsin Technical College, this program illustrates both the location and action of the major skeletal muscles." |
 |
Skeletal Muscle Tem Normal Banding Photographic Poster Print, 32x24 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
 |
Skeletal Torso VC126 by lww A life-sized flexible spine with rib cage, shoulders, pelvis, and movable femur heads with the corresponding muscles and ligaments. Shows the cervical plexus and the brachial plexus, suboccipital triangle, greater occipital nerve, sciatic nerve complex, as well as the major thoracic and lumbar muscles. The right shoulder is fully articulated and features all ligaments, capsule of shoulder joint, teres major and muscles of rotator cuff. Vertebrae are color-coded, facet syndrome at L4-5. Stand included. Size: 34" x 15" x 7 1/2" |
|
ACSM Select Symposium: Skeletal Muscle Fatigue In Old Age: Consensus And Controversy Starring: Artist Not Provided | |
 |
Skeletal Muscle Structure, Function, and Plasticity by Richard L Lieber (Author) In its Third Edition, this text addresses basic and applied physiological properties of skeletal muscle in the context of the physiological effects from clinical treatment. Anyone interested in human movement analysis and the understanding of generation and control from the musculoskeletal and neuromuscular systems in implementing movement will find this a valuable resource. A highlight color has been added to this edition's updated figures and tables, and the color plates section has been doubled, ensuring that all figures that need color treatment to clarify concepts receive this treatment. A new Clinical Problem feature uses concepts presented in each chapter in the context of a specific clinical case-for example, a spinal cord injury, a sports accident, or rehabilitation after bed... |
 |
Skeletal Muscle Structure, Function, And Plasticity by Lippincott Williams & Wilkins Skeletal Muscle Structure, Function, and Plasticity : Skeletal Muscle Structure, Function, and Plasticity Pub Date: September 2009 Product Type: Print Author/s: Richard L Lieber PhD In its Third Edition, this text addresses basic and applied physiological properties of skeletal muscle in the context of the physiological effects from clinical treatment. Anyone interested in human movement analysis and the understanding of generation and control from the musculoskeletal and neuromuscular systems in implementing movement will find this a valuable resource. A highlight color has been added to this edition's updated figures and tables, and the color plates section has been doubled, ensuring that all figures that need color treatment to clarify concepts receive this... |
| © 2009 BrightSurf.com |