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FLT PET Assesses Treatment Response on Tumor Growth—Not Size—With Non-Hodgkin's Lymphoma
June 07, 2006Positron emission tomography (PET)—with the radiolabeled thymidine analog [18F]Fluorothymidine (FLT)—is "a promising, sensitive tool" for assessing drug effects on tumor growth in patients with diffuse large B-cell lymphoma, according to a study released at SNM's 53rd Annual Meeting June 3—7 in San Diego.
"Conventional imaging modalities—such as computed tomography, ultrasound and magnetic resonance tomography—determine response to therapy by changes in tumor size," said Ken Herrmann, resident with the nuclear medicine clinic at the Technical University in Munich, Germany. "However, changes in tumor proliferation may represent a more sensitive tool in differentiating non-responding tumors," added the co-author of "Change of Tumor Cell Proliferation During R-CHOP Chemotherapy of Diffuse Large B-Cell Lymphoma (DLBCL) Measured by 18FLT PET." He indicated, "Our results need to be confirmed by future studies comprising a larger patient population and a variety of different therapy approaches."
Diffuse large B-cell lymphoma is one of some 35 different types of non-Hodgkin's lymphoma, and it accounts for about 3 in 10 of all NHL cases. DLBCL can occur at any time between adolescence and old age, and it is slightly more common in men than in women. DLBCL, like NHL, is a cancer that starts in lymphoid tissues, which includes the lymph nodes and other organs that are part of the body's system for forming blood and protecting against germs. About 59,000 new cases of non-Hodgkin's lymphoma are reported in this country annually, and almost 20,000 people will die from the disease this year.
In their study, researchers evaluated FLT PET to see if it "allows monitoring early response to therapy in patients with DLBCL lymphoma," said Herrmann. They monitored 17 patients who were treated with Rituximab immunotherapy combined with CHOP chemotherapy (R-CHOP), one of the most common chemotherapy regimens for treating NHL. Treatment with the antibody Rituximab led to a temporary increase of FLT uptake in several patients, perhaps reflecting an upregulation (an increase in the number of receptors on the surface of target cells) of DNA synthesis within the lymphoma cell compartment or a recruitment and proliferation of tumor-invading lymphocytes, noted Herrmann. "In contrast, CHOP led to a rapid decrease of FLT uptake early after application—presumably due to a reduction of tumor cell proliferation," he said.
Society of Nuclear Medicine
In their study, researchers evaluated FLT PET to see if it "allows monitoring early response to therapy in patients with DLBCL lymphoma," said Herrmann. They monitored 17 patients who were treated with Rituximab immunotherapy combined with CHOP chemotherapy (R-CHOP), one of the most common chemotherapy regimens for treating NHL. Treatment with the antibody Rituximab led to a temporary increase of FLT uptake in several patients, perhaps reflecting an upregulation (an increase in the number of receptors on the surface of target cells) of DNA synthesis within the lymphoma cell compartment or a recruitment and proliferation of tumor-invading lymphocytes, noted Herrmann. "In contrast, CHOP led to a rapid decrease of FLT uptake early after application—presumably due to a reduction of tumor cell proliferation," he said.
Society of Nuclear Medicine
Lymphoma Current Events and Lymphoma News RSSNew cancer target for non-Hodgkin's lymphoma
Physician-scientists from Weill Cornell Medical College have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, or white blood cells.
Drugs to treat anemia in cancer patients linked to thromboembolism
Medications frequently given to cancer patients to reduce their risk of anemia are associated with an increased risk of deep vein thrombosis or pulmonary embolism, according to new research led by Dawn Hershman, M.D, M.S., co-director of the breast cancer program at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center.
Researchers find new way to attack inflammation in Graves' eye disease
A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms - and improved vision - following treatment with the drug rituximab.
Approved lymphoma drug shows promise in early tests against bone cancer
A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today in the International Journal of Cancer.
Immunotherapy demonstrates long-term success in treating lymphoma
Targeted immunotherapy has been an attractive new therapeutic area for a number of cancers because it has the potential to destroy tumor cells without damaging surrounding normal tissue. New study results demonstrate high success rates using specialized white blood cells to prevent or treat lymphoma associated with the Epstein-Barr virus (EBV-lymphoma) in patients who have received a hematopoietic stem cell transplant (HSCT).
Exercise is good medicine for lymphoma patients
A healthy dose of exercise is good medicine, even for lymphoma patients receiving chemotherapy, University of Alberta researchers have found.
Childhood cancer survivors experience suicidal thoughts decades after diagnosis
Adult survivors of childhood cancer have an increased risk for suicidal thoughts, even decades after their cancer treatments ended, according to a study led by Dana-Farber Cancer Institute scientists.
New therapy for vasculitis will help patients avoid infertility and cancer
Researchers have identified that Rituxan, a drug previously approved for the treatment of non-Hodgkin's B cell lymphoma and rheumatoid arthritis, can treat severe ANCA-associated vasculitis as effectively as cyclophosphamide, the current standard therapy.
Studying cancer in pet dogs to find new treatments for human patients
A team of scientists at the National Cancer Institute (NCI) in Bethesda, USA, says that studying pet dogs with cancer could yield valuable information on how to diagnose and treat human cancers.
Scientists identify genetic cause of previously undefined primary immune deficiency disease
Researchers at the National Institutes of Health have identified a genetic mutation that accounts for a perplexing condition found in people with an inherited immunodeficiency.
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