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Consumption of fish oil does not appear to protect against abnormal heart rhythms
June 14, 2006
Patients with an implantable cardioverter defibrillator did not have a significantly lower risk of serious abnormal heart rhythms or death by consuming fish oil supplements, which had been thought to have a protective effect, according to a study in the June 14 issue of JAMA. Sudden cardiac death is responsible for approximately 50 percent of all death from cardiovascular disease in the Western world. Epidemiological studies indicate that intake of very-long-chain n-3 polyunsaturated fatty acids (omega-3 PUFAs) as present in fish or fish oil is associated with a reduction in cardiovascular death, possibly by reducing susceptibility to cardiac arrhythmia, according to background information in the article. Recent trials on fish oil and ventricular arrhythmia (abnormal heart rhythm) in patients with implantable cardioverter defibrillators (ICDs; an electrical device that can correct an abnormal heart rhythm) yielded inconclusive results.
Ingeborg A. Brouwer, Ph.D., of Wageningen University, the Netherlands, and colleagues tested the effect of omega-3 PUFAs from fish on the incidence of recurrent ventricular arrhythmia and all-cause death in a large, placebo-controlled, randomized trial of patients with ICDs. The Study on Omega-3 Fatty acids and ventricular Arrhythmia (SOFA) was conducted at 26 cardiology clinics across Europe and included 546 patients with ICDs and prior documented ventricular tachycardia (VT) or ventricular fibrillation (VF) (both are types of serious cardiac arrhythmias). Patients were randomly assigned to receive 2 grams/day of fish oil in capsules (n = 273) or placebo capsules (n = 273) for a median (midpoint) period of 356 days.
In total, 75 patients (27 percent) in the fish oil group and 81 patients (30 percent) in the placebo group received appropriate ICD intervention for VT or VF. Event-free survival did not substantially improve in the fish oil group. "In this large randomized trial we did not find evidence of strong protective effect of intake of omega-3 PUFAs from fish oil against ventricular arrhythmia in patients with ICDs. In contrast to others, we did not find that fish oil may have proarrhythmic properties," the authors conclude.
JAMA and Archives Journals
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Kirkland Signature Natural Fish Oil Concentrate with Omega-3 Fatty Acids-400 Softgels
by Omega 3 Fatty Acids
Kirkland Signature fish supply comes from deep ocean waters. Our fish oil is not supplied from farm-raised fish.
State-of-the-art molecular distillation process is used to remove PCBs and dioxins which guarantees purity and potency.
The fish oil is derived from a variety of fish species, to maximize omega-3 fatty acid concentration.
Fish Oil naturally contains the Omega-3 Fatty Acids, EPA and DHA. Omega-3 Fatty Acids help maintain heart and vascular health.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Kirkland Signature Fish Oil w/ Omega-3 Fatty Acids - One Per Day Formula - 180 Enteric Coated Softgels
by Omega 3 Fatty Acids
The enteric coating reduces the fishy odor and aftertaste by protecting the softgel until it reaches the lower intestine. Kirkland Signature fish supply comes from deep ocean waters. Our fish oil is not supplied from farm-raised fish. State-of-the-art molecular distillation process is used to remove mercury, PCBs and dioxins which guarantees purity and potency. Fish Oil naturally contains the Omega3 Fatty Acids, EPA and DHA. Omega-3 Fatty Acids help maintain heart and vascular health.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Carlson Laboratories - The Very Finest Fish Oil Lemon Flavor, 16.9 fl oz liquid
by Carlson Laboratories
Very Finest Fish Oil Lemon Flavor The Very Finest Fish Oil comes from deep, cold, ocean-water fish. It is processed and bottled in Norway to insure maximum freshness. Take by the teaspoonful, mix with foods, try it on salads! It has a refreshing lemon taste. THIS PRODUCT is regularly tested (using AOAC international protocols) for freshness, potency and purity by an independent, FDA-registered laboratory and has been determined to be fresh, fully potent and free of detectable levels of mercury, cadmium, lead, PCB's and 28 other contaminants.
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Coromega Omega-3 Supplement, Orange Flavor, Squeeze Packets, 90-Count Box
by Coromega
Daily dose squeeze packets. A delicious pudding-like alternative to capsules! Coromega provides superior bioavailability. In clinical study, the Omega-3 in Coromega was shown to enter the bloodstream faster at three times the levels of a fish oil product in softgel form. Each packet of Coromega delivers the daily intake levels of Omega-3 EPA and DHA recommended by experts for adults and children. As Pure As It Is Delicious: Coromega contains premium quality fish oil from deep, cold-water fish; molecular distillation assures product purity. To guarantee freshness and potency, our special packaging system protects the delicate Omega-3 EPA and DHA from oxygen and light a concern with Omega-3 products in bottle. Have you had your Coromega today? Guaranteed DHA & EPA Content. Pharmaceutical...
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Nature Made Omega-3 Fish Oil, 1200mg 375sg
by Nature Made
Nature Made Fish Oil supply comes from deep ocean waters. Our fish oil is not supplied from farm raised fish.
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Carlson Super Omega-3, 100 + 30 Softgels, Bottle
by Carlson
A special concentrate of fish body oils from deep, cold-water fish including mackerel and sardines which are especially rich in the essential Omega-3 fatty acids, EPA and DHA.
Each soft gel provides 590 mg of total Omega-3 fatty acids consisting of approximately 330 mg of EPA (Eicosapentaenoic Acid), 220 mg of DHA (Docosahexaenoic Acid) and 40 mg of other Omega-3's.
Natural Vitamin E is added to preserve the freshness of the fish oil in the substantial amount of 10 IU per capsule in the form of d-alpha tocopherol.
Because the fish live in the deep arctic waters, which are some of the cleanest waters in the world, the fish oil tests by independent laboratory analysis to be free of detectable levels of contaminants including: mercury, cadmium, lead and 29...
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NCB Omega 3,6,9 Alaska Deep Sea Fish Oil 1000mg 200 Softgels
by NCB Technology Co.
Supplement Facts
serving size: 2 softgels
Amount Per 2 Softgels % Daily Value
Vitamin E 10IU 33.3
EPA 360mg *
DHA 240mg *
Flaxseed Oil 60mg *
Evening Primrose Oil 60mg *
*Daily Value Not Established
Suggested Use:
Take one or two capsules with meals as dietary supplement or as directed by your physician.
Expiration Time:
At least 2 years
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Nature's Bounty Omega 3 Fish Oil Softgels, Odorless, 1000 mg, 100-Count Bottles (Pack of 2)
by Nature's Bounty
These odorless Omega-3 and Omega-6 fish oil gel caps contain EPA and DHA--two fatty acids that help support and maintain the health of your cardiovascular system. In addition, Omega-3 fish oil helps maintain healthy circulation. This unique supplement is
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Spring Valley - Fish Oil Omega-3, 1000 mg, 200 Softgels (Twin-Pack 2 Bottles of 100)
by Leiner Health Products, LLC.
The enteric coating reduces the fishy odor and aftertaste by protecting the softgel until it reaches the lower intestine. This result in more EFAs (Essential Fatty Acids) available for absorption.Fish Oil naturally contains the Omega-3 Fatty Acids, EPA and DHA. Omega-3 Fatty Acids help maintain heart and vascular health.Consumption of Omega-3 fatty acids may reduce the risk of coronary heart disease. Omega-3 fatty acids also help maintain triglyceride and cholesterol levels already in the normal range.
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Golden Alaska Deep Sea Omega-3-6-9 Fish Oil 1000mg 300 Softgels
by A.C.Commodity
Golden Alaska Deep Sea Fish Oil is known for being rich in unsaturated fatty acids and provides rich OMEGA-3 fatty acids, (Pure EPA 180mg/DHA 120mg). Golden Alaska Deep Sea Fish Oil are made from natural marine lipid concentrate and may help reduce or inhibit risk factors involved in cardiovascular disease, as well as inflammatory and immune disorders. Long term use of Family Value Alaska Deep Sea Fish Oil help prevent menopausal symptoms, promote better circulation, lower cholesterol, prevent blood clots, reduce heart related risk, and the pain of arthritis. Omega-3 and polyunsaturated fatty acids found in fish and golden alaska deep sea fish oil help to protect against heart and blood vessel disease.
Natural, essential fatty acids are essential to normal human cell and tissue growth...
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