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A link between obesity and memory? Saint Louis University research makes the connection
June 15, 2006esearchers examine the hormone that turns off hunger
ST. LOUIS — Scientists have wondered why obese patients who have diabetes also may have problems with their long-term memory. New Saint Louis University research in this month's Peptides provides a clue.
"Leptin is a hormone secreted by fat cells that tells us to stop eating. In obese people, it doesn't cross into the brain to help regulate appetite," says Susan A. Farr, Ph.D., principal investigator and associate research professor in the division of geriatric medicine at Saint Louis University School of Medicine.
"We've now found leptin affects the brain in other ways, compromising learning and memory. Low levels of leptin also could be related to cognitive deficits in disorders like type two diabetes."
Farr and her research team tested the role of leptin in learning and memory using an animal model. They found that mice navigated a maze better after they received leptin.
"We found that this drug affected the processes going into the brain," says Farr, who also is a researcher at Veterans Affairs Medical Center in St. Louis. "The mice that got the drug at the appropriate dose had improved learning and long-term memory."
Mice with elevated levels of amyloid-beta protein, the brain plaques believed to cause Alzheimer's disease, and impaired learning and memory were "super sensitive" to leptin, Farr adds.
"In the older mice that have Alzheimer's disease, leptin worked even better and at a lower dose than it did in younger mice."
Saint Louis University
"We've now found leptin affects the brain in other ways, compromising learning and memory. Low levels of leptin also could be related to cognitive deficits in disorders like type two diabetes."
Farr and her research team tested the role of leptin in learning and memory using an animal model. They found that mice navigated a maze better after they received leptin.
"We found that this drug affected the processes going into the brain," says Farr, who also is a researcher at Veterans Affairs Medical Center in St. Louis. "The mice that got the drug at the appropriate dose had improved learning and long-term memory."
Mice with elevated levels of amyloid-beta protein, the brain plaques believed to cause Alzheimer's disease, and impaired learning and memory were "super sensitive" to leptin, Farr adds.
"In the older mice that have Alzheimer's disease, leptin worked even better and at a lower dose than it did in younger mice."
Saint Louis University
Leptin Current Events and Leptin News RSSScientists find obesity alone does not cause arthritis in animals
The link between obesity and osteoarthritis may be more than just the wear and tear on the skeleton caused by added weight.
Researchers identify new brain pathway for regulating weight and bone mass
Contrary to the prevailing view, the hormone leptin, which is critical for normal food intake and metabolism, appears to regulate bone mass and suppress appetite by acting mainly through serotonin pathways in the brain.
Fish fend off invading germs with an initial response similar to the one found in people
Since the human response to infection is highly complex, research to understand how people fight infection is facilitated by studying how similar processes occur in simpler organisms.
Ice cream may target the brain before your hips, UT Southwestern study suggests
Blame your brain for sabotaging your efforts to get back on track after splurging on an extra scoop of ice cream or that second burger during Friday night's football game.
New information about how fat increases blood pressure could help identify those at risk
Some of the first information about how fat causes hypertension have been identified by researchers who say the findings should one day help identify which obese people - and maybe some thin ones too - are at risk for hypertension and which drugs would work best for them.
Caltech researchers pinpoint neurons that control obesity in fruit flies
A team of scientists from the California Institute of Technology (Caltech) have pinpointed two groups of neurons in fruit fly brains that have the ability to sense and manipulate the fly's fat stores in much the same way as do neurons in the mammalian brain.
Scarring key to link between obesity and diabetes
The team, in collaboration with University Hospital Aintree, the University of Warwick and researchers in Sweden, found that people classified as obese and those with pre-diabetes have raised levels of a protein called SPARC, that can cause tissue scarring.
Obesity increases risk of prostate cancer recurrence for both blacks and whites
A new look at a large database of prostate cancer patients shows that obesity plays no favorites when it comes to increasing the risk of recurrence after surgery: Being way overweight is equally bad for blacks and whites, say researchers at Duke University Medical Center.
Study further expands understanding of leptin's role in brain neurocircuitry
In investigating the complex neurocircuitry behind weight gain and glucose control, scientists have known that the hormone leptin plays a key role in the process.
Sleep may be factor in weight control
Could sleep be a critical component to maintaining a healthy body weight?
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