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Dental stem cells have been characterized for tooth tissue engineering
June 29, 2006Today, during the 84th General Session of the International Association for Dental Research, a team from The Forsyth Institute (Boston, MA, USA) will report that their research has demonstrated that mixed populations of cultured post-natal tooth bud cells can be used to generate bioengineered dental tissues.
Current research efforts focus on the identification and characterization of dental cell populations, scaffold materials, and design that can be most effectively used for tooth tissue engineering applications. Hoechst dye profiling and immuno-sorting methods were used to generate enriched clonal dental stem cell (DSC) lines. Expanded DSC and non-DSC lines are currently being examined, by both in vitro and in vivo methods, to define their potential to differentiate. Molecular and differentiation profiles will provide important characterizations of tooth bud cells, eventually to facilitate ongoing tooth tissue engineering efforts.
Progress in this research will be presented in a symposium, "Stem-cell-based Tissue Engineering of Craniofacial Structures," whose purpose is to present an overview of current, state-of-the-art craniofacial tissue engineering efforts via stem cells. This work was supported by the Center for Integrated Medicine and Innovative Technology (CIMIT), by The Forsyth Institute, by NIH/NIDCR grants R41 DE015445, R01 DE016132, and R21 DE016370-01, and by Dentigenix/Ivoclar-Vivadent.
International & American Association for Dental Research
International & American Association for Dental Research
Tissue Engineering News and Current Tissue Engineering Events RSSHydrogels provide scaffolding for growth of bone cells
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Sugar study is sweetener for stem cell science
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'Smart' materials get smarter with ability to better control shape and size
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Secret ingredient: nanoparticles aid bone growth
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Rice and UT-Houston join DOD push for regenerative medicine
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MIT works toward engineered blood vessels
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MIT sculpts 3-D particles with light
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