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Dental stem cells have been characterized for tooth tissue engineering
June 29, 2006Today, during the 84th General Session of the International Association for Dental Research, a team from The Forsyth Institute (Boston, MA, USA) will report that their research has demonstrated that mixed populations of cultured post-natal tooth bud cells can be used to generate bioengineered dental tissues.
Current research efforts focus on the identification and characterization of dental cell populations, scaffold materials, and design that can be most effectively used for tooth tissue engineering applications. Hoechst dye profiling and immuno-sorting methods were used to generate enriched clonal dental stem cell (DSC) lines. Expanded DSC and non-DSC lines are currently being examined, by both in vitro and in vivo methods, to define their potential to differentiate. Molecular and differentiation profiles will provide important characterizations of tooth bud cells, eventually to facilitate ongoing tooth tissue engineering efforts.
Progress in this research will be presented in a symposium, "Stem-cell-based Tissue Engineering of Craniofacial Structures," whose purpose is to present an overview of current, state-of-the-art craniofacial tissue engineering efforts via stem cells. This work was supported by the Center for Integrated Medicine and Innovative Technology (CIMIT), by The Forsyth Institute, by NIH/NIDCR grants R41 DE015445, R01 DE016132, and R21 DE016370-01, and by Dentigenix/Ivoclar-Vivadent.
International & American Association for Dental Research
International & American Association for Dental Research
Tissue Engineering Current Events and Tissue Engineering News RSSBioengineering of nerve-muscle connection could improve hand use for wounded soldiers
Modern tissue engineering developed at the University of Michigan could improve the function of prosthetic hands and possibly restore the sense of touch for injured patients.
Major improvements made in engineering heart repair patches from stem cells
University of Washington (UW) researchers have succeeded in engineering human tissue patches free of some problems that have stymied stem-cell repair for damaged hearts.
New approach to wound healing may be easy on skin, but hard on bacteria
In a presentation today (Aug. 19) to the American Chemical Society meeting, Ankit Agarwal, a postdoctoral researcher at the University of Wisconsin-Madison, described an experimental approach to wound healing that could take advantage of silver's anti-bacterial properties, while sidestepping the damage silver can cause to cells needed for healing.
Researcher says microchannels could advance tissue engineering methods
Utilizing fractal patterns similar to those created by lightning strikes, Victor Ugaz, associate professor in the Artie McFerrin Department of Chemical Engineering at Texas A&M University, has created a network of microchannels that could advance the field of tissue engineering by serving as a three-dimensional vasculature for the support of larger tissue constructs, such as human organs.
Bone's material flaws lead to disease
The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon.
Skin-like Tissue Developed from Human Embryonic Stem Cells
Dental and tissue engineering researchers at Tufts University School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have harnessed the pluripotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic human skin and the oral mucosa (the moist tissue that lines the inside of the mouth).
Automated tissue engineering on demand
Skin from a factory - this has long been the dream of pharmacologists, chemists and doctors. Research has an urgent need for large quantities of 'skin models', which can be used to determine if products such as creams and soaps, cleaning agents, medicines and adhesive bandages are compatible with skin, or if they instead will lead to irritation or allergic reactions for the consumer.
Gene therapy appears safe to regenerate gum tissue
Scientists at the University of Michigan have developed a method of gene delivery that appears safe for regenerating tooth-supporting gum tissue-a discovery that assuages one of the biggest safety concerns surrounding gene therapy research and tissue engineering.
Human embryonic stem cells
Human embryonic stem cells (hESC) provide a potentially unlimited source of oral mucosal tissues that may revolutionize the treatment of oral diseases.
First tri-continuous mesoporous Silica complex structure developed in Singapore
Singapore's Institute of Bioengineering and Nanotechnology (IBN) has developed the first tri-continuous mesoporous material using a unique surfactant template.
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Journal of Biomimetics Biomaterials and Tissue Engineering by Trans Tech Publications Ltd | |
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1875 Engineering Diagrams Tissue Weaving Drawings by old-print XXXXXXXX |
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