Ultrasound may help regrow teethJune 29, 2006Hockey players, rejoice! A team of University of Alberta researchers has created technology to regrow teeth—the first time scientists have been able to reform human dental tissue. Using low-intensity pulsed ultrasound (LIPUS), Dr. Tarak El-Bialy from the Faculty of Medicine and Dentistry and Dr. Jie Chen and Dr. Ying Tsui from the Faculty of Engineering have created a miniaturized system-on-a-chip that offers a non-invasive and novel way to stimulate jaw growth and dental tissue healing. "It's very exciting because we have shown the results and actually have something you can touch and feel that will impact the health of people in Canada and throughout the world," said Chen, who works out of the Department of Electrical and Computer Engineering and the National Institute for Nanotechnology. The wireless design of the ultrasound transducer means the miniscule device will be able to fit comfortably inside a patient's mouth while packed in biocompatible materials. The unit will be easily mounted on an orthodontic or "braces" bracket or even a plastic removable crown. The team also designed an energy sensor that will ensure the LIPUS power is reaching the target area of the teeth roots within the bone. TEC Edmonton, the U of A's exclusive tech transfer service provider, filed the first patent recently in the U.S. Currently, the research team is finishing the system-on-a-chip and hopes to complete the miniaturized device by next year. "If the root is broken, it can now be fixed," said El-Bialy. "And because we can regrow the teeth root, a patient could have his own tooth rather than foreign objects in his mouth." The device is aimed at those experiencing dental root resorption, a common effect of mechanical or chemical injury to dental tissue caused by diseases and endocrine disturbances. Mechanical injury from wearing orthodontic braces causes progressive root resorption, limiting the duration that braces can be worn. This new device will work to counteract the destructive resorptive process while allowing for the continued wearing of corrective braces. With approximately five million people in North America presently wearing orthodontic braces, the market size for the device would be 1.4 million users. In a true tale of interdisciplinary work, El-Bialy met Chen at the U of A's new staff orientation. After hearing about Chen's expertise in nanoscale circuit design and nano-biotechnology, El-Bialy explained his own research and asked if Chen might be able to help produce a tiny ultrasound device to fit in a patient's mouth. The two collaborated and eventually along with Tsui received a grant from NSERC's "Idea to Innovation," program to expand on their prototype. Dr. El-Bialy first discovered new dental tissue was being formed after using ultrasound on rabbits. In one study, published in the American Journal of Orthodontics and Dentofacial Orthopedics, El Bialy used ultrasound on one rabbit incisor and left the other incisor alone. After seeing the surprising positive results, he moved onto humans and found similar results. He has also shown that LIPUS can improve jaw growth in cases with hemifacial microsomia, a congenital syndrome where one side of the child's jaw or face is underdeveloped compared to the other, normal, side. These patients usually undergo many surgeries to improve their facial appearance. This work on human patients was presented at the World Federation of Orthodontics in Paris, September 2005. "After proving it worked, we looked at creating a smaller ultrasound carrier where we can take the patient out as a variable," said El-Bialy. "Before this, a patient has to hold the ultrasound for 20 minutes a day for a year and that is a lot to ask." The researchers are currently working on turning their prototype into a market-ready model and expect the device to be ready for the public within next two years. University of Alberta |
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| Related Ultrasound Current Events and Ultrasound News Articles High Blood Pressure Easy to Miss in Children with Kidney Disease Spot blood pressure readings in children with chronic kidney disease often fail to detect hypertension - even during doctor's office visits - increasing a child's risk for serious heart problems, according to research from Johns Hopkins Children's Center and other institutions. A report of the findings appears online in the Journal of American Society of Nephrology. Engineer designs micro-endoscope to seek out early signs of cancer Traditional endoscopes provide a peek inside patients' bodies. Now, a University of Florida engineering researcher is designing ones capable of a full inspection. Young athletes need dual screening tests for heart defects, study suggests To best detect early signs of life-threatening heart defects in young athletes, screening programs should include both popular diagnostic tests, not just one of them, according to new research from heart experts at Johns Hopkins. Routine evaluation of prostate size not as effective in cancer screening, Mayo study finds New Mayo Clinic research studied the association between prostate-specific antigen (PSA) levels and prostate size and found that routine annual evaluation of prostate growth is not necessarily a predictor for the development of prostate cancer. Newly revised guidelines for managing thyroid cancer published in Thyroid journal The American Thyroid Association has released new, revised Management Guidelines for the diagnosis and treatment of patients with thyroid nodules and thyroid cancer. Longer toes, unique ankle structure aid sprinters Longer toes and a unique ankle structure provide sprinters with the burst of acceleration that separates them from other runners, according to biomechanists. Short heels make elite sprinters super speedy When 100 m sprinters launches themselves from the starting blocks, the race can be won or lost in the first few strides. Acceleration through the first few strides is the key to winning gold. Neurologists Investigate Possible New Underlying Cause of MS Neurologists at the University at Buffalo are beginning a research study that could overturn the prevailing wisdom on the cause of multiple sclerosis (MS). Berkeley researchers create first hyperlens for sound waves Ultrasound and underwater sonar devices could "see" a big improvement thanks to development of the world's first acoustic hyperlens. Created by researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab), the acoustic hyperlens provides an eightfold boost in the magnification power of sound-based imaging technologies. Clots traveling from lower veins may not be the cause of pulmonary embolism in trauma patients A report from a team of Massachusetts General Hospital (MGH) physicians calls into question the longstanding belief that pulmonary embolism (PE) - the life-threatening blockage of a major blood vessel in the lungs - is caused in trauma patients by a blood clot traveling from vessels deep within the legs or lower torso. More Ultrasound Current Events and Ultrasound News Articles |
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