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Researchers present Phase 2 clinical results for Acologix AC-100
June 30, 2006Meets goal of stimulating the formation of new dentin, has favorable safety profile
Today, researchers from Acologix (Hayward, CA, USA), the University of California (San Francisco, USA), and the University of Connecticut (Simsbury, USA) will announce the results of a Phase 2 clinical trial of AC-100 (also known as Dentonin), reporting that it met its primary goal of stimulating the formation of new dentin when applied directly to tooth defects, and demonstrating that AC-100 has a favorable safety profile.
Administration of AC-100 resulted in a clear trend in stimulating the formation of new dentin, compared with a placebo. This effect was seen across a wide variety of cavity depths. Importantly, the efficacy of AC-100 was seen most dramatically in the deepest cavities (RDT < 0.5 mm), where the clinical utility of the approach is most needed.
Because of its unique hard-tissue-regenerating properties, the researchers believe that AC-100 represents a novel approach to promoting dentin formation and could be a promising treatment for patients undergoing a wide range of dental restoration procedures. Drilling during these procedures can irritate the dental pulp and reduce the dentin layer that protects the pulp, causing pain and sensitivity, and sometimes leading to complications, including tooth loss. Therefore, it may be beneficial to stimulate the formation of new dentin to protect the pulp from this damage.
Results and the method of application of AC-100 used in this Phase 2 clinical study demonstrate that a novel biological approach to dentistry can be introduced as a supplement to routine dental care.
AC-100 is a novel synthetic peptide derived from an endogenous human protein produced by bone and dental cells. In addition to dental applications, it is being studied for periodontal, oral bone, dental implant, and orthopedic applications.
International & American Association for Dental Research
Because of its unique hard-tissue-regenerating properties, the researchers believe that AC-100 represents a novel approach to promoting dentin formation and could be a promising treatment for patients undergoing a wide range of dental restoration procedures. Drilling during these procedures can irritate the dental pulp and reduce the dentin layer that protects the pulp, causing pain and sensitivity, and sometimes leading to complications, including tooth loss. Therefore, it may be beneficial to stimulate the formation of new dentin to protect the pulp from this damage.
Results and the method of application of AC-100 used in this Phase 2 clinical study demonstrate that a novel biological approach to dentistry can be introduced as a supplement to routine dental care.
AC-100 is a novel synthetic peptide derived from an endogenous human protein produced by bone and dental cells. In addition to dental applications, it is being studied for periodontal, oral bone, dental implant, and orthopedic applications.
International & American Association for Dental Research
Dentin Current Events and Dentin News RSSMale sabertoothed cats were pussycats compared to macho lions
Despite their fearsome fangs, male sabertoothed cats may have been less aggressive than many of their feline cousins, says a new study of male-female size differences in extinct big cats.
Open wide and say 'zap'
A group of researchers in Australia and Taiwan has developed a new way to analyze the health of human teeth using lasers.
How to manage erosion caused by everyday beverages
Researchers have warned people to beware of the damage that acidic beverages have on teeth. Yet, for some, the damage and problems associated with drinking sodas, citric juices or certain tea may have already begun to take effect.
Dry Mouth Linked to Prescription and Over the Counter Drugs
Approximately ninety-one percent of dentists say patients complaining about dry mouth are taking multiple medications, according to a nationwide member survey conducted by the Academy of General Dentistry (AGD).
Nanotechnology may increase longevity of dental fillings
Tooth-colored fillings may be more attractive than silver ones, but the bonds between the white filling and the tooth quickly age and degrade.
Durability of dental fillings improves if the enzyme activity of teeth is inhibited
Composite dental fillings have one problematic feature, in that the bond between the filling and the dental tissue deteriorates over time - in fact, sometimes by as much as 50 per cent in one year. As the bond deteriorates, it may allow bacteria to enter and this brings a high risk of further tooth decay.
Novel hydrogel systems for dentin regeneration
Dental caries, or tooth decay, continues to be the most prevalent infectious disease in the world, presenting significant public health challenges and socio-economic consequences.
Reconstructing mandibular defects with bioengineered tooth and bone
Current strategies for jaw reconstruction require multiple procedures, first to repair the bone defect to offer sufficient support, and then to place the tooth implant.
How insulin TORC2 blood sugar levels: glowing mice light the way
With the help of genetically engineered mice whose livers turned into glowing light bulbs, researchers at the Salk Institute for Biological Studies have illuminated the underpinnings of an insidious and growing health concern- type II diabetes.
Laser used to help fight root canal bacteria: ADA Journal
High-tech dental lasers used mainly to prepare cavities for restoration now can help eliminate bacteria in root canals, according to research published in the July issue of The Journal of the American Dental Association (JADA).
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Dentin / Pulp Complex: Proceedings Of The International Conference On Dentin / Pulp Complex 2001 by Tatsuya Ishikawa (Editor), Kazuto Takahashi (Editor), Takeyasu Maeda (Editor), Hideaki Suda (Editor), Masaki Shimono (Editor), Takashi Inoue (Editor) Presents papers from the 4th International Conference on Dentin/Pulp Complex,the Pulp Biology Group held in Kazusa, Japan, in 2002. Discusses molecular and genetic aspects of tooth development, the role of peripheral nerves in the regulation and function of pulp and dentine, and ` immunobiology of pulpal/periapical disease. Detailed halftone illustrations. Softcover. | |
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Dentin: Webster's Timeline History, 1899 - 2007 by Icon Group International (Author) Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Dentin," including when used in literature (e.g. all authors that might have Dentin in their name). As such, this book represents the largest compilation of timeline events associated with Dentin when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics,... |
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