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U of M researchers discover compounds to shrink tumors
July 06, 2006Researchers at the University of Minnesota have developed novel anti-cancer drugs to treat solid tumors. These "small molecules" belong to a class of pharmaceutical agents called anti-angiogenics. The new compounds are a refined form of drugs that effectively reduce blood flow to the tumor, thereby inhibiting tumor growth. The results of the study appear in the July 5 issue of the Journal of the National Cancer Institute.
"This is a novel class of drugs that increases the potential for good, effective treatment for cancer patients with tumors," said Kevin Mayo, Ph.D., principle investigator and professor of biochemistry, molecular biology and biophysics at the University of Minnesota Medical School.
There is currently a protein anti-angiogenic agent approved by the FDA for clinical use. These new tumor-targeting compounds were designed to mimic the functional part of an anti-angiogenic protein. But, because the compounds are not proteins themselves, they have the advantage of possibly being taken in pill form and being less costly to produce.
In animal studies with mice, the compounds inhibited tumor growth by up to 80 percent, and in combination with chemotherapy tumors essentially disappeared. Although the compounds proved effective against solid tumors, researchers believe they have potential to treat liquid tumors as well, such as the type found in leukemia and other blood cancers.
"Our next step is to treat people with the drug in FDA-approved clinical trials," said Mayo.
University of Minnesota
In animal studies with mice, the compounds inhibited tumor growth by up to 80 percent, and in combination with chemotherapy tumors essentially disappeared. Although the compounds proved effective against solid tumors, researchers believe they have potential to treat liquid tumors as well, such as the type found in leukemia and other blood cancers.
"Our next step is to treat people with the drug in FDA-approved clinical trials," said Mayo.
University of Minnesota
Tumor Current Events and Tumor News RSSLaser therapy can aggravate skin cancer
High irradiances of low-level laser therapy (LLLT) should not be used over melanomas.
Common pain relief medication may encourage cancer growth
Although morphine has been the gold-standard treatment for postoperative and chronic cancer pain for two centuries, a growing body of evidence is showing that opiate-based painkillers can stimulate the growth and spread of cancer cells.
Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
UCLA researchers create 'fly paper' to capture circulating cancer cells
Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor.
'Cross-talk' mechanism contributes to colorectal cancer
Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors.
Thoughtful words help couples stay fighting fit
Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.
Young athletes need dual screening tests for heart defects, study suggests
To best detect early signs of life-threatening heart defects in young athletes, screening programs should include both popular diagnostic tests, not just one of them, according to new research from heart experts at Johns Hopkins.
Largest gene study of childhood IBD identifies 5 new genes
In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.
Research reveals lipids' unexpected role in triggering death of brain cells
The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Children's Research Hospital investigators.
Fertility procedures need not delay breast cancer treatment for younger women
A new study published in the November issue of the Journal of the American College of Surgeons shows that breast cancer patients under 40 years old who undergo fertility preservation do not face a significant delay in the treatment of their disease when their care is coordinated in a timely fashion.
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Tumor by Joshua Hale Fialkov (Author), Noel Tuazon (Author) From the Harvey Award-nominated creative team of Elk's Run comes Tumor, the critically acclaimed sensation that was the first graphic novel to debut exclusively on the Kindle E-Book Reader! Tumor is the story of Frank Armstrong, a man at the boot heel of the world, barely scraping up a living as a private investigator in modern day Los Angeles. He finally lands a big case, finding the missing daughter of a drug kingpin, just as he's taken by the symptoms of a late-stage brain tumor. Memories blend with reality, as the missing girl case starts to seep into the memory of his own missing wife from 20 years prior. Now, with days, maybe even hours, left to live, he must save this girl, while the one thing he's relied on all of his life fails him - his mind! | |
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Curveball: When Life Throws You a Brain Tumor by Liz Holzemer (Author) Life seemed idyllic for thirty-two-year-old Liz Holzemer. Wife of Major League Baseball pitcher Mark Holzemer, Liz was enjoying a successful career as a journalist when an MRI revealed a baseball-size brain tumor she soon found out was called meningioma. Told with clarity and unwavering humor, this book is an inspirational and informative account of one woman’s battle for her life. It shows how she emerged from this frightening diagnosis and two brain surgeries retaining her remarkable spirit of survival and renewed sense of purpose and hope. With practical information about meningioma and brain surgery, Curveball is a manual for people who face life-altering challenges and is also proof that one need not fight such battles alone. |
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PIZZA TUMOR Funny Definition (Gotta See it to Believe it -TRUST ME, YOU'LL LAUGH) Ladies T-Shirt White Large by T-ShirtFrenzy The Design/Saying is printed on the front of this T-Shirt, we use the newest & best technology to print the design with great inks that are cured into the product. This new high tech way of producing garments is very fade resistant. WE DO NOT USE TRANSFERS. It is great, since you dont have that thick transfer feeling. The feel is very smooth and comfortable. T-ShirtFrenzy offers over 30,000 designs on tons of products to offer millions of variations. You can search our store for something for everyone on your gift list or shop for yourself (our personal favorite). Please contact us with questions. |
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Alternative Health & Herbs Remedies Skin Tumors (external), 1-Ounce Bottle (Pack of 2) by Alternative Health & Herbs Remedies Use externally for skin tumors, skin cancer, infection, and skin disorders. |
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Brain Tumor Awareness Ribbon Mouse Pad by MyHeritageWear.com The Brain Tumor Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Brain Tumor Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Brain Tumor Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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