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Sperm created in the laboratory from embryonic stem cells produce viable progeny
July 12, 2006Scientists have demonstrated for the first time that embryonic stem (ES) cells cultured in the laboratory can produce sperm with the capacity to produce viable offspring. The research, published in the July issue of Developmental Cell, opens many exciting avenues for future studies, including investigation of mechanisms involved in sperm production and development of new treatment strategies for infertility.
Previous studies have shown that ES cells grown in the laboratory can differentiate into primordial germ cells that then give rise to cells resembling mature egg and sperm cells, known as gametes. However, the functionality of the gametes has not been thoroughly tested and many questions about the viability of these cells remain unanswered. Dr. Karim Nayernia and Dr. Wolfgang Engel from the Institute of Human Genetics at the University of Goettingen in Goettingen, Germany and colleagues developed a new strategy for generating mature sperm cells in the laboratory using ES cells from mice and went on to test the functionality of the ES-derived sperm.
ES cells were treated with specific factors know to direct sperm production and screened for characteristics associated with primordial and spermatagonial stem cells. The researchers demonstrated that these cells could be further differentiated into mature sperm in the laboratory or could be transplanted into the testes of mice where they retained the capacity develop into sperm. Intra-cytoplasmic injection of the ES-derived sperm into mouse eggs resulted in successful fertilization and the resulting early stage embryos were successfully transplanted into mice. Six of the seven mice born developed into adult mice.
The results of this study establish that the ES cell derived cell lines can produce functional sperm in the laboratory which can be used to successfully fertilize eggs and support full-term development into embryos and adult mice. "Our approach provides an accessible in vitro model system for studies of mammalian gametogenesis, as well as for developing new strategies for generation of transgenic mice and may one day facilitate nuclear transfer technology and infertility treatment," offers Dr. Nayernia.
Cell Press
The results of this study establish that the ES cell derived cell lines can produce functional sperm in the laboratory which can be used to successfully fertilize eggs and support full-term development into embryos and adult mice. "Our approach provides an accessible in vitro model system for studies of mammalian gametogenesis, as well as for developing new strategies for generation of transgenic mice and may one day facilitate nuclear transfer technology and infertility treatment," offers Dr. Nayernia.
Cell Press
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A team of Jackson Laboratory scientists have figured out a simple, cost-effective process to freeze mouse sperm and get it to achieve high fertilization rates with mouse eggs.
Acidification of the sea hampers reproduction of marine species
By absorbing carbon dioxide from the atmosphere, and from the human use of fossil fuels, the world's seas function as a giant buffer for the Earth's life support system.
Newly discovered proteins in seminal fluid may affect odds of producing offspring
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Soy foods are associated with lower sperm concentrations
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Minimally invasive treatment improves male fertility
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Stem cell chicken and egg debate moves to unlikely arena: the testes
Logic says it has to be the niche. As air and water preceded life, so the niche, that hospitable environment that shelters adult stem cells in many tissues and provides factors necessary to keep them young and vital, must have emerged before its stem cell dependents.
Environmental pollutant has sex-skewing effect
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Obese men have less semen, more sperm abnormalities, and should lose weight before trying for a baby
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