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Powerful radiation source to further cancer research
July 12, 2006Plans to construct Europe's most intense terahertz (THz) radiation source to further development of cancer research are underway at the University of Liverpool
Physicists will construct an ultra-high intensity THz beamline and attempt to destroy skin cancer cells specially grown in a new tissue culture facility. The experiments will help scientists understand how to use this technology in future treatments for the disease in humans.
The THz beamline, funded by the Northwest Regional Development Agency (NWDA) through its North West Science Fund, will be developed using the prototype Fourth Generation Light Source (4GLS) being constructed at CCLRC Daresbury Laboratory, which will be used to develop light sources used in X-ray technology, laser studies and radiation sources.
Physicist, Professor Peter Weightman, said: "The prototype 4GLS facility is based on an Energy Recovery Linear accelerator. The energy produced by firing electrons around this accelerator will partly be used to power the THz beamline, which will link up to a tissue culture facility developed with scientists at the University of Nottingham.
"The culture facility will be used to grow skin cancer cells and the THz radiation will target the source of the cancer. THz is absorbed by water and cancer cells retain water, so the THz radiation should be consumed by the cell and kill it off at the source."
Terahertz radiation has also been used in the detection of concealed weapons, explosives and drugs as it has the ability to penetrate a variety of materials such as clothing, paper, cardboard, wood, masonry, plastics and ceramics. THz can also pick up on vibrations and rotations of molecules and has been useful in identifying molecules floating in space.
The team at Liverpool hope to develop these applications using the most powerful source of broad band terahertz available in Europe—a thousand times more powerful than current laboratory sources.
This will be the first time THz technology has been used on cancer cells and it will also be developed to characterise genetic material. THz has the capability of identifying mutations in DNA, which could help medics identify pharmaceutical therapies that will be compatible with individual patients' DNA information.
Dr George Baxter, NWDA Director of Science and Innovation, said: "The NWDA is delighted to support this innovative project that will help develop new technology for the treatment of cancer. Investment in this project forms part of the NWDA's commitment to build and sustain a knowledge based economy for England's North West.\\\
University of Liverpool
"The culture facility will be used to grow skin cancer cells and the THz radiation will target the source of the cancer. THz is absorbed by water and cancer cells retain water, so the THz radiation should be consumed by the cell and kill it off at the source."
Terahertz radiation has also been used in the detection of concealed weapons, explosives and drugs as it has the ability to penetrate a variety of materials such as clothing, paper, cardboard, wood, masonry, plastics and ceramics. THz can also pick up on vibrations and rotations of molecules and has been useful in identifying molecules floating in space.
The team at Liverpool hope to develop these applications using the most powerful source of broad band terahertz available in Europe—a thousand times more powerful than current laboratory sources.
This will be the first time THz technology has been used on cancer cells and it will also be developed to characterise genetic material. THz has the capability of identifying mutations in DNA, which could help medics identify pharmaceutical therapies that will be compatible with individual patients' DNA information.
Dr George Baxter, NWDA Director of Science and Innovation, said: "The NWDA is delighted to support this innovative project that will help develop new technology for the treatment of cancer. Investment in this project forms part of the NWDA's commitment to build and sustain a knowledge based economy for England's North West.\\\
University of Liverpool
Radiation Current Events and Radiation News RSSVisual assistance for cosmic blind spots
A bit of imagination on the part of a measuring instrument wouldn't be a bad thing. It could help to add data from areas where the instrument is unable to measure.
Multiple health concerns surface as winter, vitamin D deficiences arrive
A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."
Supervolcano eruption -- in Sumatra -- deforested India 73,000 years ago
A new study provides "incontrovertible evidence" that the volcanic super-eruption of Toba on the island of Sumatra about 73,000 years ago deforested much of central India, some 3,000 miles from the epicenter, researchers report.
Possible Link Studied Between Childhood Abuse and Early Cellular Aging
Children who suffer physical or emotional abuse may be faced with accelerated cellular aging as adults, according to new research from Butler Hospital and Brown University.
Rare pancreatic cancer patients may live longer when treated with radiation therapy
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy.
Nuclear weapons: Predicting the unthinkable
If a nuclear weapon were detonated in a metropolitan area, how large would the affected area be? Where should first responders first go? According to physicist Fernando Grinstein, we have some initial understanding to address these questions, but fundamental issues remain unresolved.
New cancer target for non-Hodgkin's lymphoma
Physician-scientists from Weill Cornell Medical College have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, or white blood cells.
Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
A protein known to stimulate blood vessel growth has now been found to be responsible for the cell overgrowth in the development of polyps that characterize one of the most severe forms of sinusitis, a study by Johns Hopkins researchers suggests.
Experts: Failure to focus on farming will undermine global climate agreement and increase hunger
Alarmed by a substantial oversight in the global climate talks leading up to the United Nations Climate Change Conference in Copenhagen next month, more than 60 of the world's most prominent agricultural scientists and leaders underscored how the almost total absence of agriculture in the agreement could lead to widespread famine and food shortages in the years ahead.
Extinct moa rewrites New Zealand's history
DNA recovered from fossilised bones of the moa, a giant extinct bird, has revealed a new geological history of New Zealand, reports a study published this week in the Proceedings of the National Academy of Sciences.
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