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Connect the Quantum Dots
July 19, 2006A new study, published today in the current issue of the Proceedings of the National Academy of Sciences has significant implications for the design of disease markers and the development of chemoreceptors used in human biomedical research. The groundbreaking study, entitled, "A Mechanism to Signal Receptor-Substrate Interactions with Luminescent Quantum Dots", demonstrates that quantum dots can one day replace conventional organic dyes in biomedical applications.
By using the unique photophysical properties of quantum dots, researchers Drs. Francisco Raymo, Ibrahim Yildiz, and Massimilliano Tomasulo were able to identify operating principles to probe molecular recognition events with luminescence measurements. These findings demonstrate that mechanisms based on photoinduced electron transfer can be exploited to transduce a recognition event into a significant change in the luminescence of a quantum dot. This research proves this important fundamental principle and lay the necessary groundwork for researchers to further improve its sensitivity, stability and reproducibility for biomedical applications.
"Our method has a long-term impact on biomedical diagnostic applications which currently rely on the fluorescence of organic dyes," says Francisco Raymo, Ph.D., associate professor of chemistry in the University of Miami's College of Arts and Sciences. "For example, our strategy can be designed to signal specific disease markers in biological samples thus replacing conventional organic dyes in a diversity of imaging and sensing applications."
Fluorescence microscopy and spectroscopy have become invaluable analytical tools in biomedical research but rely on the fluorescence of organic dyes which have limited luminescent properties. Quantum dots have superior photophysical properties and will presumably replace conventional organic dyes in biomedical applications. These findings will stimulate the use of quantum dots in the biomedical research and development of disease markers and chemosensors.
"On its own this research paper is very significant and ahead of its time in the field of nanotechnology," says Alexey Titov, Licensing Manager for the University of Miami's Office of Technology Transfer. "However, it also has commercial applications which are a truly outstanding and rare combination."
Two patent applications have been filed by University of Miami Office of Technology Transfer on behalf of Dr. Raymo and colleagues for these inventions and the university is in the process of finding an industrial partner capable of commercializing these inventions.
Quantum dots, one of the smallest nanoscience research tools, range from 2 to 10 nanometers in diameter; nearly 3 million quantum dots would be needed to fit within the width of a thumb. By virtue of their distinct colors, quantum dots have quickly found their way into homes in many electronic lasers including the new PlayStation 3 and high-definition DVD players. Nanotechnology, the understanding and control of matter at dimensions of roughly 1 to 100 nanometers, is valuable research since matter at the nanoscale has unique properties that enable novel applications. Medical researchers work at the nano-scales can develop new drug delivery methods, therapeutics and pharmaceuticals.
University of Miami Rosenstiel School of Marine & Atmospheric Science
Fluorescence microscopy and spectroscopy have become invaluable analytical tools in biomedical research but rely on the fluorescence of organic dyes which have limited luminescent properties. Quantum dots have superior photophysical properties and will presumably replace conventional organic dyes in biomedical applications. These findings will stimulate the use of quantum dots in the biomedical research and development of disease markers and chemosensors.
"On its own this research paper is very significant and ahead of its time in the field of nanotechnology," says Alexey Titov, Licensing Manager for the University of Miami's Office of Technology Transfer. "However, it also has commercial applications which are a truly outstanding and rare combination."
Two patent applications have been filed by University of Miami Office of Technology Transfer on behalf of Dr. Raymo and colleagues for these inventions and the university is in the process of finding an industrial partner capable of commercializing these inventions.
Quantum dots, one of the smallest nanoscience research tools, range from 2 to 10 nanometers in diameter; nearly 3 million quantum dots would be needed to fit within the width of a thumb. By virtue of their distinct colors, quantum dots have quickly found their way into homes in many electronic lasers including the new PlayStation 3 and high-definition DVD players. Nanotechnology, the understanding and control of matter at dimensions of roughly 1 to 100 nanometers, is valuable research since matter at the nanoscale has unique properties that enable novel applications. Medical researchers work at the nano-scales can develop new drug delivery methods, therapeutics and pharmaceuticals.
University of Miami Rosenstiel School of Marine & Atmospheric Science
Quantum Dots Current Events and Quantum Dots News RSSDigging deep into diamonds, applied physicists advance quantum science and technology
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SNM's nanomedicine summit advances molecular imaging
SNM's Nanomedicine and Molecular Imaging Summit wrapped up today in Albuquerque, N.M., with in-depth discussion-and a high sense of energy looking ahead.
Study shows that delivering stem cells improves repair of major bone injuries in rats
A study published this week reinforces the potential value of stem cells in repairing major injuries involving the loss of bone structure.
A solid case of entanglement
For the first time, physicists have convincingly demonstrated that physically separated particles in solid-state devices can be quantum-mechanically entangled.
University of Toronto physicists lay the groundwork for cooler, faster computing
University of Toronto quantum optics researchers Sajeev John and Xun Ma have discovered new behaviours of light within photonic crystals that could lead to faster optical information processing and compact computers that don't overheat.
Small nanoparticles bring big improvement to medical imaging
If you're watching the complex processes in a living cell, it is easy to miss something important-especially if you are watching changes that take a long time to unfold and require high-spatial-resolution imaging.
JQI researchers create entangled photons from quantum dots
To exploit the quantum world to the fullest, a key commodity is entanglement-the spooky, distance-defying link that can form between objects such as atoms even when they are completely shielded from one another.
Transforming Nanowires Into Nano-Tools Using Cation Exchange Reactions
A team of engineers from the University of Pennsylvania has transformed simple nanowires into reconfigurable materials and circuits, demonstrating a novel, self-assembling method for chemically creating nanoscale structures that are not possible to grow or obtain otherwise.
U-M physicists create first atomic-scale map of quantum dots
University of Michigan physicists have created the first atomic-scale maps of quantum dots, a major step toward the goal of producing "designer dots" that can be tailored for specific applications.
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