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Cerebrospinal fluid used to deliver therapeutics for Lou Gehrig's disease to brain
July 28, 2006Researchers from the University of California, San Diego have shown that instead of trying to deliver therapeutic agents for neurodegenerative diseases across the highly impermeable blood-brain barrier via the blood, therapeutic molecules known as antisense oligonucleotides can be delivered to the brain and spinal cord through the cerebrospinal fluid (CSF) at doses shown to slow the progression of amyotrophic lateral sclerosis (ALS), also referred to as Lou Gehrig's disease, in rats.
The aggregation of toxic proteins in the central nervous system (CNS) underlies many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and ALS. Several strategies for removing excess proteins from the brain have been tried, but few have been successful due to the impermeability of the protective blood-brain barrier, which prevents substances in the blood from entering brain tissue. In a study in rats appearing online on July 27 in advance of print publication in the August issue of the Journal of Clinical Investigation, Timothy Miller, Richard Smith, and colleagues delivered effective doses of antisense oligonucleotides throughout all brain regions affected in the major neurodegenerative diseases and to all levels of the spinal cord through the CSF. Once produced, CSF circulates from the brain to all regions of the CNS, yielding complete replacement 3 times a day. Exploiting this process and using second-generation oligonucleotides with enhanced tolerability and potency, the authors were able to modulate and deliver effective doses of antisense oligonucleotides. Antisense oligonucleotides to the enzyme superoxide dismutase reduced protein and mRNA levels in the CNS. Delivery of antisense therapy initiated after the onset of symptoms slowed disease progression in a rat model of ALS. This establishes that direct delivery of antisense oligonucleotides through the CSF can be an effective means of treating neurodegenerative diseases when the appropriate toxic protein is known.
Journal of Clinical Investigation
Cerebrospinal Fluid Current Events and Cerebrospinal Fluid News RSSNeurologists Investigate Possible New Underlying Cause of MS
Neurologists at the University at Buffalo are beginning a research study that could overturn the prevailing wisdom on the cause of multiple sclerosis (MS).
Cocaine exposure during pregnancy leads to impulsivity in male, not female, monkeys
Adult male monkeys exposed to cocaine while in the womb have poor impulse control and may be more vulnerable to drug abuse than female monkeys, even a decade or more after the exposure, according to a new study by researchers at Wake Forest University School of Medicine. The findings could lead to a better understanding of human drug abuse.
Urate in blood and spinal fluid may predict slower decline in patients with Parkinson's disease
Higher concentration of urate (an antioxidant) in the blood and spinal fluid of patients with early Parkinson's disease is associated with slower rates of clinical decline.
Study supports possible role of urate in slowing Parkinson's disease progression
By examining data from a 20-year-old clinical trial, a research team based at the MassGeneral Institute for Neurodegenerative Diseases (MGH-MIND) and Harvard School of Public Health (HSPH), has found evidence supporting the findings of their 2008 study - that elevated levels of the antioxidant urate may slow the progression of Parkinson's disease.
Investment in Parkinson's disease data bank yields potential therapy
Individuals with Parkinson's disease who have higher levels of a metabolite called urate in their blood and in cerebrospinal fluid (CSF) have a slower rate of disease progression.
Rochester-led Parkinson's study pays off again, 2 decades later
Parkinson disease progresses more slowly in patients who have higher levels of urate, a chemical that at very high level is associated with gout, scientists have found.
Researchers report benefits of new standard treatment study for rare pediatric brain cancer
A team of researchers led by The University of Texas M. D. Anderson Cancer Center unveiled results today from the largest-ever collaborative study addressing the treatment of a rare pediatric brain tumor.
Are the monoamines involved in shaping conduct disorders?
Antisocial and aggressive behaviours represent a widespread and expensive social problem. Recent research has convincingly shown that there is a strong interaction between genetic inheritance and environment for development of personality and behaviour.
Researchers find 2 more genetic risk factors for Alzheimer's disease
An international team of scientists has identified two more genetic risk factors for Alzheimer's disease. The findings are reported in the online edition of the journal Nature Genetics.
How meningitis bacteria attack the brain
A specific protein on the surface of a common bacterial pathogen allows the bacteria to leave the bloodstream and enter the brain, initiating the deadly infection known as meningitis.
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Cerebrospinal Fluid in Clinical Practice by David N. Irani MD (Author) Given the evolution of cerebrospinal testing (CSF) testing methods, the near future is certain to see an explosion of new CSF analysis methodologies. Broad-based and extensively illustrated, Cerebrospinal Fluid in Clinical Practice provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to diagnosis, and future directions in CSF analysis. It examines the alterations of the composition of CSF in relation to diseases and disorders of the nervous system, emphasizing the findings that are useful in clinical practice. This expansive reference is perfect regardless of your level of experience in central nervous system diseases. Provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to... |
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Cerebrospinal Fluid Disorders by Conor Mallucci (Editor), Spyros Sgouros (Editor) More than 50 global experts in neurology and related disciplines bring you the most effective diagnostic and management guidelines for treating patients with cerebrospinal fluid (CSF) disorders. Why this book is a critical resource for you and your patients: COMPREHENSIVE CONTENT - that details CSF disorders and their effects on the brain and spine occurring in all developmental stages provides you with the tools you need to manage complications and other issues at any stage, for patients of all ages KEY UPDATES - top international leaders in the field provide you with up-to-date information and recent developments you trust and can utilize in your practice CLEAR ORGANIZATION - of sections into background information, disease discussion, surgical aspects, and... |
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Integrated Cytology of Cerebrospinal Fluid by Michael Torzewski (Author), Karl J. Lackner (Author), Jürgen Bohl (Author), Clemens Sommer (Author) Cytologic examination of the cerebrospinal fluid is a technically simple, yet productive, diagnostic procedure. Integrated Cytology of Cerebrospinal Fluid is a practical guide to this method used in the diagnosis of different pathologies. High-quality slides depict the common cerebrospinal fluid cell types, cell anomalies in inflammatory conditions and neoplastic and non-neoplastic disorders, and cases with contaminants. The integrated approach includes the use of immunocytochemical, histological, and immunohistological illustrations and quantitative date in addition to descriptions and photographs of cytologic preparations. |
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Physiology and Pathology of the Cerebrospinal Fluid (1920) by William Boyd (Author) Purchase of this book includes free trial access to www.million-books.com where you can read more than a million books for free. This is an OCR edition with typos. Excerpt from book: CHAPTER VIII PHYSICAL PROPERTIES It cannot be said that the physical properties of the cerebro- spinal fluid are very striking or of a specially positive character. Indeed, although much time and study have been devoted to them the results have not been remarkable either from the academic or the practical standpoint. To this statement, however, two exceptions must be made. Both the color and the pressure of the fluid are worthy of, and have received, careful consideration. COLOR The cerebrospinal fluid is a perfectly clear, limpid, colorless fluid, which in appearance cannot be distinguished from... |
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Cerebrospinal Fluid Journal of Clinical & Experimental Resea by Walter De Gruyter & Co | |
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American Polarity Therapy Assocation: Healing Potency of Cerebrospinal Fluid, Parts 1 and 2 Also With: Franklyn Sills (Primary Contributor) | |
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Cerebrospinal Fluid in Diseases of the Nervous System by Robert A. Fishman (Author) University of California, San Francisco. Extensively revised edition of a text for neurologists, neurosurgeons, internists, neuroradiologists on the physiological and biochemical aspects of the cerebrospinal fluid in disease. Expanded bibliography. Illustrated. DNLM: Central Nervous System Diseases. | |
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The Blood-Cerebrospinal Fluid Barrier by Wei Zheng (Editor), Adam Chodobski (Editor) Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue. The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The... |
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Cerebrospinal Fluid in Health and in Disease: -1919 by Abraham Levinson (Author) Originally published in 1919. This volume from the Cornell University Library's print collections was scanned on an APT BookScan and converted to JPG 2000 format by Kirtas Technologies. All titles scanned cover to cover and pages may include marks notations and other marginalia present in the original volume. |
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Physiology and Pathophysiology of the Cerebrospinal Fluid by Davson (Author) |
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