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Mortality rate is twice as high in patients with pneumonia caused by highly resistant bacteria
August 01, 2006Patients suffering from hospital-acquired pneumonia caused by a type of bacteria that is highly resistant to virtually all antibiotics are twice as likely to die as patients infected with other, less resistant bacteria. A study published today in the journal Critical Care shows for the first time that the highly resistant, metallo-beta-lactamase-producing Pseudomonas aeruginosa is associated with a much higher mortality rate than other types of the bacteria in patients with hospital-acquired pneumonia. The authors conclude that this may be due to the use of inappropriate antimicrobial treatments for infections with metallo-beta-lactamase-producing P. aeruginosa, and suggest that therapeutic approaches should be reviewed in hospitals with high prevalence of the bacteria.
Alexandre Zavascki from Universidade Federal do Rio Grande do Sul in Porto Alegre, Brazil, and colleagues from other institutions in Brazil studied 150 patients admitted to two hospitals in Porto Alegre and suffering from hospital-acquired pneumonia.
The results of Zavascki et al.'s study show that 42 patients were infected with metallo-beta-lactamase-producing P. aeruginosa. For these patients, the 30-day mortality rate was 57.1%, compared with 29.6% for patients infected with other P. aeruginosa strains. Only half of the patients infected with the highly resistant bacteria were treated with appropriate antibiotics. But even when the recommended treatment was used, mortality was still high, suggesting that the optimal treatment for these highly resistant bacteria is yet to be found.
BioMed Central
BioMed Central
Resistant Bacteria Current Events and Resistant Bacteria News RSSU.S. and European Experts Applaud Creation of New Transatlantic Task Force on Global Antibiotic Resistance Threat
Experts on both sides of the Atlantic applaud President Barack Obama and Swedish Prime Minister Fredrik Reinfeldt, representing the European Union (EU) Presidency, for establishing a transatlantic task force to address antibiotic resistance, an urgent and growing problem that threatens patient safety and public health worldwide.
Bacteria 'launch a shield' to resist attack
Researchers from the University of Copenhagen and the Technical University of Denmark along with other collaborators in Denmark and the US found that the bacterium Pseudomonas aeruginosa can 'switch on' production of molecules that kill white blood cells - preventing the bacteria being eliminated by the body's immune system.
McMaster researchers discover a new antibacterial lead
Antibiotic resistance has been a significant problem for hospitals and health-care facilities for more than a decade. But despite the need for new treatment options, there have been only two new classes of antibiotics developed in the last 40 years.
Pinhead-size worms + robot = new antibiotics
In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics.
Resistance to antibiotics: When 1+1 is not 2
The evolution of multiple antibiotic resistances is a global and difficult problem to eradicate.
New silver nanoparticle skin gel for healing burns
Scientists in India are reporting successful laboratory tests of a new and potentially safer alternative to silver-based gels applied to the skin of burn patients to treat infections. With names like silver sulfadiazine and silver nitrate, these germ-fighters save lives and speed healing.
Singapore nanotechnology combats fatal brain infections
Doctors may get a new arsenal for meningitis treatment and the war on drug-resistant bacteria and fungal infections with novel peptide nanoparticles developed by scientists at the Institute of Bioengineering and Nanotechnology (IBN) of Singapore and reported in Nature Nanotechnology.
Antibiotics-resistant gulls worry scientists
The resistance pattern for antibiotics in gulls is the same as in humans, and a new study by Uppsala University researchers shows that nearly half of Mediterranean gulls in southern France have some form of resistance to antibiotics.
Bacteria create aquatic superbugs in waste treatment plants
For bacteria in wastewater treatment plants, the stars align perfectly to create a hedonistic mating ground for antibiotic-resistant superbugs eventually discharged into streams and lakes.
Study finds multidrug-resistant gram-negative bacteria high in long-term care
The prevalence of a certain form of drug-resistant bacteria, called multidrug-resistant gram-negative (MDRGN) organisms, far surpassed that of two other common antimicrobial-resistant infections in long-term care facilities, according to a study conducted by researchers at Hebrew SeniorLife's Institute for Aging Research.
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THE KILLERS WITHIN: THE DEADLY RISE OF DRUG-RESISTANT BACTERIA by Michael Shnayerson (Author) | |
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