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Genome circularization and RNA virus replication
August 01, 2006As featured on the cover of the August 15th issue of G&D, an Argentinian research team, led by Dr. Andrea Gamarnik, report on their recent discovery of a novel mechanism of dengue virus replication.
Approximately 50 million people are infected with dengue virus each year, resulting in about 24,000 deaths world-wide. Dengue virus is a mosquito-borne member of the flavivirus family, whose other members cause encephalitis, hemorrhagic fevers, and hepatitis.
Dengue virus is a plus strand RNA virus that replicates its genome by a viral-encoded RNA-dependent RNA polymerase. Dr. Gamarnik and colleagues identified a structure at the 5' end of the RNA genome - what they term the "SLA" - that is recognized by the viral RNA polymerase. The replication machinery is then able, through the circularization of the dengue virus genome, to interact with the 3' initiation site, thousands of nucleotides downstream, and to initiate replication of the dengue virus genome.
The authors hypothesis that "Since similar 5'-3' long-range interactions were observed in many viral RNA genomes, the mechanism proposed for DV may represent a wide-spread strategy for viral RNA replication."
Cold Spring Harbor Laboratory
The authors hypothesis that "Since similar 5'-3' long-range interactions were observed in many viral RNA genomes, the mechanism proposed for DV may represent a wide-spread strategy for viral RNA replication."
Cold Spring Harbor Laboratory
Virus Replication Current Events and Virus Replication News RSSTriple-Combo Drug Shows Promise Against Antiviral-Resistant Swine Flu, UAB Researcher Says
An experimental drug cocktail that includes three prescriptions now widely available offers the best hope in developing a single agent to treat drug-resistant H1N1 swine flu, says a virology researcher in the University of Alabama Birmingham (UAB) Division of Pediatric Infectious Diseases.
New Strategy for Inhibiting Virus Replication
Viruses need living cells for replication and production of virus progeny. Thus far, antiviral therapy primarily targets viral factors but often induces therapy resistance. New improved therapies attempt to targets cellular factors that are essential for viral replication.
MicroRNAs grease the cell's circadian clockwork
Most of our cells possess an internal clock, a group of genes displaying a cyclic expression pattern that reaches a peak once a day.
USC researchers uncover mechanism that allows influenza virus to evade the body's immune response
Researchers at the University of Southern California (USC) have identified a critical molecular mechanism that allows the influenza virus to evade the body's immune response system.
Visualizing virus replication in 3 dimensions
Dengue fever is the most common infectious disease transmitted by mosquitoes - some 100 million people around the world are infected. Researchers at the Hygiene Institute at Heidelberg University Hospital were the first to present a three-dimensional model of the location in the human cell where the virus is reproduced.
Penn Study Identifies How Ebola Virus Avoids the Immune System
Researchers at the University of Pennsylvania School of Medicine have likely found one reason why the Ebola virus is such a powerful, deadly, and effective virus. Using a cell culture model for Ebola virus infection, they have discovered that the virus disables a cellular protein called tetherin that normally can block the spread of virus from cell to cell.
Study first to show that RNA interference can facilitate vaccine development
Pharmaceutical companies and universities are racing to develop drugs that use the gene silencing mechanism known as RNA interference to treat a host of diseases.
Well-armed immune cells help long-term nonprogressors contain HIV
To help develop an effective HIV vaccine, researchers are trying to better understand how the immune systems of a small minority of HIV-infected people known as long-term non-progressors (LTNPs) contain the virus naturally.
UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
Bavituximab, an anti-viral drug developed by UT Southwestern Medical Center researchers, shows promise as a new strategy to fight viral diseases, including potential bioterrorism agents.
Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
Key differences in immune system signaling and the production of specific immune regulatory molecules may explain why some primates are able to live with an immunodeficiency virus infection without progressing to AIDS-like illness, unlike other primate species, including rhesus macaques and humans, that succumb to disease.
More Virus Replication Current Events and Virus Replication News Articles
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Plant Viruses Struc & Replication Vol 1 by C. L. Mandahar (Author) | |
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SciEd Virus Wall Charts; Virus Replication Chart by BioCam Virus Replication Chart |
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Replication of Negative Strand Viruses: International Symposium Proceedings (Developments in cell biology) by D.H.L. Bishop (Editor), Richard W. Compans (Editor) | |
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Recent Advances in RNA Virus Replication 2006 by Kathleen Hefferon (Author), Kathleen L. Hefferon (Editor) This is the second part of a series on the molecular biology of virus application and has been compiled for those who would like to become acquainted with RNA virus replication as well as for specialists in the field. Special emphasis has been placed on research for scientists who are interested in further understanding the replication systems of DNA viruses with the purpose of developing viral expression vectors for gene therapy or for foreign expression of proteins. |
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VIRUS REPLICATION: An entry from Gale's World of Microbiology and Immunology by Gale (Publisher) This digital document is an article from World of Microbiology and Immunology, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses. The length of the article is 930 words. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Covers the concepts, theories, discoveries, and pioneers in microbiology and immunology, using a mix of traditional academic and topical articles, this title addresses current ethical, legal, and social issues with special emphasis given to biological warfare and terrorism. | |
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Recent Advances in DNA Virus Replication 2006 by Kathleen L. Hefferon (Author), Kathleen L. Hefferon (Editor) This volume has been complied for those who are interested in familiarizing themselves with DNA virus replication in general, as well as for experts in the field who would find such a series of reviews assembled into a single book of great benefit for their own research programs. Molecular biologists and researchers in the field of medicine who are interested in further understanding the replication systems of DNA viruses with the purpose of developing viral expression vectors for gene therapy or for foreign expression of proteins will find this book of particular interest. |
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The Biochemistry of Virus Replication Proceedings of the Fourth Meeting of the E by S.G. & Froholm, L.O., Editors; Nygaard, Symposi Laland (Author) |
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