 |
|
UCLA study shows altering fatty acid levels in diet may reduce prostate cancer growth rate
August 01, 2006UCLA researchers found that altering the fatty acid ratio found in the typical Western diet to include more omega-3 fatty acids and decrease the amount of omega-6 fatty acids may reduce prostate cancer tumor growth rates and PSA levels.
Published in the Aug. 1 issue of the journal Clinical Cancer Research, this initial animal-model study is one of the first to show the impact of diet on lowering an inflammatory response known to promote prostate cancer tumor progression and could lead to new treatment approaches.
The omega-6 fatty acids contained in corn, safflower oils and red meats are the predominant polyunsaturated fatty acids in the Western diet. The healthier marine omega-3 fatty acids are found in cold-water fish like salmon, tuna and sardines.
"Corn oil is the backbone of the American diet. We consume up to 20 times more omega-6 fatty acids in our diet compared to omega-3 acids," said principal investigator Dr. William Aronson, a professor in the department of urology at the David Geffen School of Medicine at UCLA and a researcher with UCLA's Jonsson Cancer Center. "This study strongly suggests that eating a healthier ratio of these two types of fatty acids may make a difference in reducing prostate cancer growth, but studies need to be conducted in humans before any clinical recommendations can be made."
Scientists used a special mouse model for hormone-sensitive prostate cancer that closely mirrors the disease in humans. Researchers fed one group of mice a diet comprised of 20 percent fat with a healthy one-to-one ratio of omega-6 to omega-3 fatty acids. A second group of mice were fed the same diet but with the fat derived from mostly omega-6 fatty acids.
The study showed that tumor cell growth rates decreased by 22 percent and PSA levels were 77 percent lower in the group receiving a healthier balance of fatty acids compared with the group that received predominantly omega-6 fatty acids.
The most likely mechanism for the tumor reductions, according to researchers, was due to an increase of the prostate tumor omega-3 fatty acids DHA and EPA and a lowering of the omega-6 acid known as arachidonic acid. These three fatty acids compete to be converted by cyclooxgenase enzymes (COX-1 and COX-2) into prostaglandins, which can become either pro-inflammatory and increase tumor growth, or anti-inflammatory and reduce growth.
Researchers found that pro-inflammatory prostaglandin (PGE-2) levels were 83 percent lower in tumors in the omega-3 group than in mice on the predominantly omega-6 fatty acid diet, demonstrating that higher levels of DHA and EPA may lead to development of more anti-inflammatory prostaglandins.
"This is one of the first studies showing changes in diet can impact the inflammatory response that may play a role in prostate cancer tumor growth," Aronson said. "We may be able to use EPA and DHA supplements while also reducing omega-6 fatty acids in the diet as a cancer prevention tool or possibly to reduce progression in men with prostate cancer."
Currently, the research team is conducting a clinical trial with men who are undergoing prostate removal due to cancer to compare the effects of a low-fat diet using omega-3 supplements and a balanced Western diet. Aronson said that positive findings from this study may lead to larger clinical trials.
In addition, Aronson said that further study might show that COX-2 inhibitors or non-steroidal anti-inflammatories (NSAIDS) combined with omega-3 supplements also may lower the inflammatory response in prostate cancer development.
University of California-Los Angeles
"Corn oil is the backbone of the American diet. We consume up to 20 times more omega-6 fatty acids in our diet compared to omega-3 acids," said principal investigator Dr. William Aronson, a professor in the department of urology at the David Geffen School of Medicine at UCLA and a researcher with UCLA's Jonsson Cancer Center. "This study strongly suggests that eating a healthier ratio of these two types of fatty acids may make a difference in reducing prostate cancer growth, but studies need to be conducted in humans before any clinical recommendations can be made."
Scientists used a special mouse model for hormone-sensitive prostate cancer that closely mirrors the disease in humans. Researchers fed one group of mice a diet comprised of 20 percent fat with a healthy one-to-one ratio of omega-6 to omega-3 fatty acids. A second group of mice were fed the same diet but with the fat derived from mostly omega-6 fatty acids.
The study showed that tumor cell growth rates decreased by 22 percent and PSA levels were 77 percent lower in the group receiving a healthier balance of fatty acids compared with the group that received predominantly omega-6 fatty acids.
The most likely mechanism for the tumor reductions, according to researchers, was due to an increase of the prostate tumor omega-3 fatty acids DHA and EPA and a lowering of the omega-6 acid known as arachidonic acid. These three fatty acids compete to be converted by cyclooxgenase enzymes (COX-1 and COX-2) into prostaglandins, which can become either pro-inflammatory and increase tumor growth, or anti-inflammatory and reduce growth.
Researchers found that pro-inflammatory prostaglandin (PGE-2) levels were 83 percent lower in tumors in the omega-3 group than in mice on the predominantly omega-6 fatty acid diet, demonstrating that higher levels of DHA and EPA may lead to development of more anti-inflammatory prostaglandins.
"This is one of the first studies showing changes in diet can impact the inflammatory response that may play a role in prostate cancer tumor growth," Aronson said. "We may be able to use EPA and DHA supplements while also reducing omega-6 fatty acids in the diet as a cancer prevention tool or possibly to reduce progression in men with prostate cancer."
Currently, the research team is conducting a clinical trial with men who are undergoing prostate removal due to cancer to compare the effects of a low-fat diet using omega-3 supplements and a balanced Western diet. Aronson said that positive findings from this study may lead to larger clinical trials.
In addition, Aronson said that further study might show that COX-2 inhibitors or non-steroidal anti-inflammatories (NSAIDS) combined with omega-3 supplements also may lower the inflammatory response in prostate cancer development.
University of California-Los Angeles
Fatty Acids Current Events and Fatty Acids News RSSLet them eat snail
A nutritionist in Nigeria says that malnutrition and iron deficiency in schoolchildren could be reduced in her country by baking up snail pie.
Fat collections linked to decreased heart function
Researchers from Boston University School of Medicine (BUSM) have shown that fat collection in different body locations, such as around the heart and the aorta and within the liver, are associated with certain decreased heart functions.
Magnetic nanoparticles to simultaneously diagnose, monitor and treat
Whether it's magnetic nanoparticles (mNPs) giving an army of 'therapeutically armed' white blood cells direction to invade a deadly tumour's territory, or the use of mNPs to target specific nerve channels and induce nerve-led behaviour (such as the life-dependant thumping of our hearts), mNPs have come a long way in the past decade.
Wolves, moose and biodiversity: An unexpected connection
Moose eat plants; wolves kill moose. What difference does this classic predator-prey interaction make to biodiversity?
Mediterranean diet associated with reduced risk of depression
Individuals who follow the Mediterranean dietary pattern -rich in vegetables, fruits, nuts, whole grains and fish- appear less likely to develop depression, according to a report of the University of Navarra, published in the October issue of Archives of General Psychiatry.
Biologists discover 'death stench' is a universal ancient warning signal
The smell of recent death or injury that repels living relatives of insects has been identified as a truly ancient signal that functions to avoid disease or predators, biologists have discovered.
Ice cream may target the brain before your hips, UT Southwestern study suggests
Blame your brain for sabotaging your efforts to get back on track after splurging on an extra scoop of ice cream or that second burger during Friday night's football game.
Second-hand smoking results in liver disease, study finds
A team of scientists at the University of California, Riverside has found that even second-hand tobacco smoke exposure can result in nonalcoholic fatty liver disease (NAFLD), a common disease and rising cause of chronic liver injury in which fat accumulates in the liver of people who drink little or no alcohol.
Half of the fish consumed globally is now raised on farms, study finds
Aquaculture, once a fledgling industry, now accounts for 50 percent of the fish consumed globally, according to a new report by an international team of researchers. And while the industry is more efficient than ever, it is also putting a significant strain on marine resources by consuming large amounts of feed made from wild fish harvested from the sea, the authors conclude.
Nonagenarian researcher petitions FDA to ban trans fats
"I request to ban trans fats from the American diet." Thus begins a 3,000-word petition to the Food and Drug Administration, the work of a man on a dogged, decades-old crusade to eradicate trans fats from food.
More Fatty Acids Current Events and Fatty Acids News Articles
 |
Source Naturals Essential Fatty Acids (Complete), 120 softgels by Source Naturals Dietary supplement. Source Naturals Complete Essential Fatty Acids is an excellent blend of omega-3 and omega-6 fatty acids. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid which plays a significant role in cerebral development throughout the life style, especially during the crucial period of fetal development and infancy. Gamma-Linolenic Acid (GLA) is an omega-6 fatty acid used by most cells in the body to produce soothing PGE1 prostaglandins. Essential Fatty Acids, or EFA's, act as precursors to molecules such as prostaglandins, thromboxanes and leukotrienes, which help regulate cellular function. EFA's have been shown to play a role in blood pressure maintenance, immune system balance, sustaining healthy skin, and providing nutritional support during women's cycles (These... |
 |
Evolution Fatty Acid (Primary Contributor) |
 |
Kirkland Signature Natural Fish Oil Concentrate with Omega-3 Fatty Acids-400 Softgels by Omega 3 Fatty Acids Kirkland Signature fish supply comes from deep ocean waters. Our fish oil is not supplied from farm-raised fish. State-of-the-art molecular distillation process is used to remove PCBs and dioxins which guarantees purity and potency. The fish oil is derived from a variety of fish species, to maximize omega-3 fatty acid concentration. Fish Oil naturally contains the Omega-3 Fatty Acids, EPA and DHA. Omega-3 Fatty Acids help maintain heart and vascular health.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
 |
Fatty Acids in Foods and their Health Implications,Third Edition (Food Science and Technology) by Ching Kuang Chow (Editor) Since the publication of the bestselling second edition, mounting research into fatty acids reveals new and more defined links between the consumption of dietary fats and their biological health effects. Whether consuming omega-3 to prevent heart disease or avoiding trans fats to preserve heart health, it is more and more clear that not only the quantity but the type of fatty acid plays an important role in the etiology of the most common degenerative diseases. Keeping abreast of the mechanisms by which fatty acids exert their biological effects is crucial to unraveling the pathogenesis of a number of debilitating chronic disorders and can contribute to the development of effective preventive measures. Thoroughly revised to reflect the most resent research findings, Fatty Acids in... |
 |
MRM Smart Blend Advanced CLA, GLA and Omega Fatty Acid Complex Softgels, 240-Count Bottle by MRM Dietary Supplement. Poliquin Performance Series. Supports bodyfat reduction. Supports cardiovascular health. Supports optimal immune health. (These statements have not been evaluated by the Food & Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.) Smart Blend is a cutting edge, proprietary blend of Smart Fats that contains important fatty acids, which often become depleted in many athletes, exercise enthusiasts as well as average people. Because your body does not manufacture essential fatty acids on its own, Smart Blend provides the necessary for life fatty acids that have not been shown to be deficient in the standard American diet. MRM, along with renowned strength coach Charles Poliquin, have engineered an extremely unique fatty... |
 |
Animal Essentials Omega 3 Plus - Essential Fatty Acids for Dogs and Cats - 8oz by Animal Essentials |
 |
Kirkland Signature Fish Oil w/ Omega-3 Fatty Acids - One Per Day Formula - 180 Enteric Coated Softgels by Omega 3 Fatty Acids The enteric coating reduces the fishy odor and aftertaste by protecting the softgel until it reaches the lower intestine. Kirkland Signature fish supply comes from deep ocean waters. Our fish oil is not supplied from farm-raised fish. State-of-the-art molecular distillation process is used to remove mercury, PCBs and dioxins which guarantees purity and potency. Fish Oil naturally contains the Omega3 Fatty Acids, EPA and DHA. Omega-3 Fatty Acids help maintain heart and vascular health.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
 |
Babys Only Organic DHA & ARA Fatty Acids Supplements (Box) by Natures One Baby's Only Organic - Dha & Ara Fatty Acid 30 / .10 oz. Packs |
 |
Arbonne NutriMinC RE9 REsist Fatty Acid Dietary Supplement |
 |
Nutrabolics SuperFats, Advanced Fatty Acid Matrix, 120 Softgels by Nutrabolics Dietary supplement. With CLA 90%, sesamin & korean pine nut extract. SuperFats is a cutting edge proprietary blend of SuperFats containing important fatty acids and lipids which may be depleted in the diets of many athletes and exercise enthusiasts. Regular supplementation with SuperFats provides optimal support to your program for supporting fat loss and increasing muscle tissue recovery. (These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat or prevent any disease. Before beginning any program of weight management, consult your health care practioner.) Made in Canada. |
| © 2009 BrightSurf.com |