Science Current Events | Science News | Brightsurf.com
 

Meth Promotes Spread of Virus in HIV-Infected Users

August 07, 2006

BUFFALO, N.Y. - Researchers at the University at Buffalo have presented the first evidence that the addictive drug methamphetamine, or meth, also commonly known as "speed" or "crystal," increases production of a docking protein that promotes the spread of the HIV-1 virus in infected users.

The investigators found that meth increases expression of a receptor called DC-SIGN, a "virus-attachment factor," allowing more of the virus to invade the immune system.

"This finding shows that using meth is doubly dangerous," said Madhavan P.N. Nair, Ph.D., first author on the study, published in the online version of the Journal of Neuroimmune Pharmacology. The study will appear in print in the September issue of the journal.

"Meth reduces inhibitions, thus increasing the likelihood of risky sexual behavior and the potential to introduce the virus into the body, and at the same time allows more virus to get into the cell," said Nair, professor of medicine and a specialist in immunology in the UB School of Medicine and Biomedical Sciences.

His research centers on dendritic cells, which serve as the first line of defense again pathogens, and two receptors on these cells - HIV binding/attachment receptors (DC-SIGN) and the meth-specific dopamine receptor. Dendritic cells overloaded with virus due to the action of methamphetamine can overwhelm the T cells, the major target of HIV, and disrupt the immune response, promoting HIV infection.

"Now that we have identified the target receptor, we can develop ways to block that receptor and decrease the viral spread," said Nair. "We have to approach this disease from as many different perspectives as possible.

"If we could prevent the upregulation of the meth-specific dopamine receptor by blocking it, we may be able to prevent the interaction of meth with its specific receptors, thereby inhibiting the virus attachment receptor," said Nair.

"Right now, we don't know how the virus-attachment receptor and meth-specific receptors interact with each other, leading to the progression of HIV disease in meth-using HIV-infected subjects. That is the next question we want to answer.

"Since meth mediates its effects through interacting with dopamine receptors present on the cells, and meth increases DC-SIGN, which are the HIV attachment receptors, use of dopamine receptor blockers during HIV infection in meth users could be beneficial therapeutically to reduce HIV infection in these high-risk populations," Nair said.

Additional researchers on the publication, all from the UB Department of Medicine, are Supriya Mahajan, Ph.D., research assistant professor; Donald Sykes, Ph.D., research associate professor; Meghana V. Bapardekar, Ph.D., postdoctoral associate, and Jessica L. Reynolds, Ph.D., research assistant professor.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York. The School of Medicine and Biomedical Sciences is one of five schools that constitute UB's Academic Health Center.

University at Buffalo


Related Meth Current Events and Meth News Articles


'Chemsex' needs to become a public health priority
Chemsex - sex under the influence of illegal drugs - needs to become a public health priority, argue experts in The BMJ this week.

TSRI scientists find hyped new recreational drug 'flakka' is as addictive as bath salts
Scientists at The Scripps Research Institute (TSRI) have found using animal models that the new recreational drug alpha-PVP ("flakka") seems equivalently potent as a stimulant, and therefore as addictive, as its chemical cousin MDPV ("bath salts").

Meth users face substantially higher risk for getting Parkinson's disease
In addition to incurring serious dental problems, memory loss and other physical and mental issues, methamphetamine users are three times more at risk for getting Parkinson's disease than non-illicit drug users, new research from the University of Utah and Intermountain Healthcare shows.

Laser sniffs out toxic gases from afar
Scientists have developed a way to sniff out tiny amounts of toxic gases -- a whiff of nerve gas, for example, or a hint of a chemical spill -- from up to one kilometer away.

Asteroid impacts on Earth make structurally bizarre diamonds, say ASU scientists
Scientists have argued for half a century about the existence of a form of diamond called lonsdaleite, which is associated with impacts by meteorites and asteroids.

Long-acting Anti-Methamphetamine Antibody Demonstrates Protective Benefits for Meth Addiction Treatment
A recently developed Adeno-Associated Virus (AAV)-based medication has the potential to offer substantial protective effects for patients attempting to cease methamphetamine use.

'Swingers' multiple drug use heightens risk of sexually transmitted diseases
These so called 'swingers' need to be offered more tailored interventions by sexual health services to help encourage safer sexual practices and prevent the spread of sexually transmitted infections (STIs).

CU Denver study shows zoning regulations impact where marijuana dispensaries can locate
Municipal zoning regulations may push marijuana dispensaries into low income, minority areas, according to a study just released by the University of Colorado Denver.

A tricky balancing act: Antibiotics versus the gut microbiota
Antibiotics are valuable, potentially life-saving tools that have significantly reduced human morbidity and mortality. Unfortunately, antibiotics may also have unintended consequences from their off-target effects that may increase the risk of many long-term conditions.

Stress steroid mediated withdrawal anxiety in dependent rats reversible by flumazenil
SUNY Downstate Medical Center announced today that Sheryl Smith, PhD, professor of physiology and pharmacology, has published new findings demonstrating a reproducible pathology that may help shed light on anxiety and mood volatility in methamphetamine dependence.
More Meth Current Events and Meth News Articles

Quitting Crystal Meth: What to Expect & What to Do: A Handbook for the first Year of Recovery from Crystal Methamphetamine

Quitting Crystal Meth: What to Expect & What to Do: A Handbook for the first Year of Recovery from Crystal Methamphetamine
by Joseph Sharp (Author)


Drawing upon the wisdom and experiences of recovered addicts and recovery professionals, QUITTING CRYSTAL METH: WHAT TO EXPECT & WHAT TO DO is a concise handbook that explains what you'll experience during the first year of recovery from crystal methamphetamine. It is a no-nonsense how-to manual written by a recovered meth addict for the addict who wants to quit. Joseph Sharp explains, "I wrote the book I wished I'd had when I was trying to quit--a straightforward manual that would give me some idea of what to expect and better my chances at quitting Tina forever." QUITTING CRYSTAL METH is divided along the five stages of meth recovery. Additional chapters look at "Crystal Meth Anonymous Meetings - What It's All About" and "What About Relapse?" Upbeat and positive, QUITTING CRYSTAL METH:...

Meth Uncensored

Meth Uncensored
by Wayne Huffman (Author)


From the anal beads in Mexico to the daily life of an incarcerated meth cook. These are the stories and random thoughts of a long-time meth head and cook. You will be left shaking your head and wondering why these people put themselves in these situations and do these things to themselves and to each other ON PURPOSE! From the author of Meth: a Memoir, Meth Uncensored is full of the stories he left out of the first book, but should have included.

Meth=Sorcery : Know the Truth

Meth=Sorcery : Know the Truth
by Steve Box (Author)


This book is about methamphetamine and how it is enslaving millions of lives worldwide.It exposes methamphetamine for what it really is,sorcery.The author explains how meth stole everything he had and almost his life.This book reveals the truth that set him free and how you or your loved ones can be set free too.

Beneath a Meth Moon

Beneath a Meth Moon
by Jacqueline Woodson (Author)


Hurricane Katrina took her mother and granmother. And even though Laurel Daneau has moves on to a new life--one that includes a new best friend, a spot on the cheerleading squad, and dating the co-captain of the football team--she can't get past the pain of that loss. Then her new boyfriend introduces her to meth, and Laurel is instantly seduced by its spell, the way it erases, even if only temporarily, her memories. Soon Laurel is completely hooked, a shell of her former self, desperate to be whole again, but lacking the strength to break free. But with the help of a new friend--and the loyalty of an old one--she is able to rewrite her own story and move on with her own life.

Dreamlike in quality and weaving flashbacks to the hurricane in with Laurel's present-day struggles,...

Overcoming Crystal Meth Addiction: An Essential Guide to Getting Clean

Overcoming Crystal Meth Addiction: An Essential Guide to Getting Clean
by Steven J. Lee (Author)


In Overcoming Crystal Methamphetamine Addiction, one of the few books to address the topic for a general audience, Dr. Steven Lee, MD, a psychiatrist who specializes in crystal meth addiction, offers a complete guide to the drug, its effects, and how to overcome it. Based on extensive scientific and social research and drawing from his professional experience, he covers everything from the definition and history of crystal meth to the physical and psychological effects; from dealing with the addictive personality to helping a friend or family member cope with it. He focuses on understanding rather than outright condemnation of the drug, and empathetically covers all of the crucial questions: What is crystal meth? How is it made? How does it affect the body? How do you know if you're...

Crystal Clean: A mother's struggle with meth addiction and recovery

Crystal Clean: A mother's struggle with meth addiction and recovery
by Kimberly Wollenburg (Author)


"There are precious few things in this life of which I am certain. One is the love I have for my son, Andy... The other thing of which I am certain is this: no one wants to be an addict." - from the book. Here's what readers have to say: "Kim's writing style is clear, lucid, revealing, and on a par with the best of skilled non-fiction authors - Thor Heyerdahl, Thomas Thompson, even James Michener or my favorite, Jan de Hartog, and she is able to make the reader relive her addictions - all of them - to the point that I HAD to put the book down several times and "de-tox" myself, or at least breathe normally, before I could return to it. I've never felt so much inside the skin of someone who is going through the horror of addiction as when reading this biography." "Kim has cleansed her...

A Life Half Lived: A True Story of Love, Addiction, Tragedy, and Hope

A Life Half Lived: A True Story of Love, Addiction, Tragedy, and Hope
by Darryl Rodgers (Author)


Twenty year-old Speedy Chase Rodgers seemed to have it all. His family loved him dearly. His generosity and sense of humor made him popular among his peers. His speed, agility, and competitive nature made him a force to be reckoned with on the football field. Young ladies were drawn to his good looks, quiet charm, and spontaneity. How will his family and friends cope when Chase makes choices that ultimately lead to his death in a tragic car wreck? A Life Half Lived gives the reader a glimpse inside the modern drug culture and the consequences that come with it.

Meth = Sorcery: Know The Truth by Steve Box

Meth = Sorcery: Know The Truth by Steve Box
by Steve Box


This book is about methamphetamine and how it is enslaving millions of lives worldwide.It exposes methamphetamine for what it really is,sorcery.The author explains how meth stole everything he had and almost his life.This book reveals the truth that set him free and how you or your loved ones can be set free too.

Shadow People: How Meth-driven Crime Is Eating At the Heart of Rural America

Shadow People: How Meth-driven Crime Is Eating At the Heart of Rural America
by Scott Thomas Anderson (Author)


Literary Nonfiction. Sleepless and paranoid methamphetamine addicts often see "shadow people" in the darkest hours of the night. Yet it is the addicts themselves that cast a shadow over the most peaceful corners of America, driven in large numbers to commit fraud, identity theft, burglary, domestic violence, elder abuse, child abuse, assault and murder.

In 2010, award-winning journalist Scott Thomas Anderson began to explore the link between crime and methamphetamine, spending sixteen months as an embedded reporter with rural county law enforcement agencies and traveling to dozens of small towns battling the epidemic across the United States. The result is SHADOW PEOPLE, an unflinching look at the havoc and heartache meth spawns in the open countryside—a window to how the...

Meth a Memoir

Meth a Memoir
by Wayne Huffman (Author)


Meth: a Memoir is both raw and disturbing. Written from within the confines of prison walls, the author gives an unflinching look at a life surrounded by drugs and drug use. It is a no holds barred, no feelings spared story that drags you, kicking and screaming, through the inner realms of the meth world. As an addict and meth cook, the author knows that there are aspects to the meth lifestyle that can only be understood by experiencing it for yourself. To help you understand this sub-culture, and those who call that world home, the author will take you into the meth world as no one else has ever done before. Everyone in America is affected by meth in one way or another. That simple fact makes this book a MUST READ.

© 2016 BrightSurf.com