Science Current Events | Science News | Brightsurf.com
 

Contagious canine cancer

August 11, 2006

The source of a cancer that affects dogs around the world has been traced by scientists and vets at UCL (University College London) to a single wolf or dog, which probably lived in China or Siberia more than 250 years ago. In canine transmissible venereal tumour (CTVT), the cells of the tumour itself are transmitted between dogs during sex. No equivalent form of contagious cancer exists in humans, but the new findings challenge current thinking about the nature of cancer.

Some human cancers such as cervical cancer may be considered to be 'catchable', as they are initiated by viruses transmitted between people - in the case of cervical cancer, by certain types of papilloma virus. What is unusual about CTVT in dogs, however, is that no virus is involved - the cancer itself is effectively passed on.

In a paper published in the journal Cell, veterinarian researcher Dr Claudio Murgia conducted forensic DNA tests on tumour tissues from 16 dogs affected by CTVT. The dogs were being treated for the cancer by vets in Italy, India and Kenya who provided the biopsies. He found that in all cases, the tumours were genetically different from the affected dog - in other words, the cancer had come from a different dog. A further analysis of 40 tumours archived in vet labs in five continents showed that the tumours were genetically almost identical and demonstrated that CTVT originally came from a single source and has since spread across the globe.

To trace this source, the UCL team worked with geneticists and computer experts in Chicago and compared the DNA in the tumours to that in specific dog breeds. They found that the cancer most likely first arose in either a wolf or an 'old' Asian dog breed such as a Husky or Shih Tzu. The number of mutations accumulated in the DNA also enabled the researchers to obtain a rough estimate the age of the disease, which came out at around 1,000 years and not less than 250 years old.

CTVT is a serious but seldom fatal disease. Unless the dogs are already in poor condition, the tumours usually regress three to nine months after their appearance, leaving the dogs immune to re-infection. But that leaves enough time for the dogs and bitches to pass the tumour on through further sexual encounters. The tumour is rarely seen in pedigree dogs because they are not allowed casual sex, but it is relatively common in strays. It does not occur in the UK, because quarantine regulations (for rabies) effectively screened it out.

Professor Robin Weiss of the UCL Division of Infection and Immunity, who led the research team, says: "It appears that man's best friend can be its own worst enemy. Our study shows that CTVT has become a parasite that has long outlived its original host.

"Our discovery is of much broader significance than simply a disease in dogs. Firstly, CTVT represents the longest-lived cancer 'clone' known to science. It contradicts the current view that cancer cells generate more and more mutations and inevitably become more aggressive if untreated.

"Secondly, recent research in Australia has revealed the existence of a newly emerged tumour in Tasmanian Devils that also appears to be caused by transmissible cancer cells, in this case by biting. Devils are an endangered marsupial species and there are fears that the new tumour might finally kill them off altogether. The methods used at UCL for dogs could help to determine whether the Devil tumour is also a 'parasitic' cancer.

"Thirdly, our findings also show that cancer cells can evade immune responses and CTVT is particularly smart in this regard. On rare occasions cancer cells have been transmitted from one human to another by hiding in organ transplants. Because the recipient is treated with immunosuppressants in order to prevent rejection, the transferred cancer cells can then grow into tumours just like CTVT. That is why people who have suffered from cancer should not become organ donors.\\\

University College London


Related Canine Cancer Current Events and Canine Cancer News Articles


Dogs accelerate the advance of new cancer treatments for both pets and people
A Science Translational Medicine review suggests integrating dogs with naturally occurring cancers into studies of new drug therapeutics could result in better treatments for our four-legged friends while helping inform therapeutic development for human cancers.

Scientists investigated molecular processes for targeted dog cancer therapy
Almost every second dog above the age of ten years develops cancer. Modern tumor therapy combines surgery, radiation therapy and novel drug treatment options. While surgery and radiotherapy ensure adequate treatment for all animals at the University of Veterinary Medicine, Vienna, there is a growing gap in the treatment with modern therapeutics.

FACC-29 gathers authenticated canine cancer cell lines for research and drug development
Much of what we know about cancer and many modern medicines that treat it grow from experiments on cancer cells.

Gene signatures predict doxorubicin response in K9 osteosarcoma
There are two chemotherapies commonly used to treat bone cancer in dogs: doxorubicin and carboplatin. Some dogs respond better to one drug than to the other.

First cancer immunotherapy for dogs developed
Nearly every second dog develops cancer from the age of ten years onward. A few therapies derived from human medicine are available for dogs.

Scientists put a pox on dog cancer
Researchers report that myxoma - a pox virus that afflicts rabbits but not humans, dogs or any other vertebrates so far studied - infects several different types of canine cancer cells in cell culture while sparing healthy cells.

UT MD Anderson, Texas A&M Team Up to Treat Canine Lymphoma
A new immunotherapy for companion dogs with advanced-stage non-Hodgkin lymphoma (NHL) has been shown to improve survival while maintaining quality of life, according to a study published in the journal Scientific Reports.

Chromosomal "Breakpoints" Linked to Canine Cancer
North Carolina State University researchers have uncovered evidence that evolutionary "breakpoints" on canine chromosomes are also associated with canine cancer. Mapping these "fragile" regions in dogs may also have implications for the discovery and treatment of human cancers.

U of M researchers look to dogs to better understand intricacies of bone cancer
A new University of Minnesota discovery may help bone cancer patients fight their disease more effectively, according to new research published in the September issue of Bone.

NC State Researchers Find Soy May Aid in Treating Canine Cancers
Researchers at North Carolina State University are looking to soy as a way to make traditional canine cancer therapy more effective, less stressful for the dog and less costly for the owners.
More Canine Cancer Current Events and Canine Cancer News Articles

The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity

The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity
by Demian Dressler (Author), Susan Ettinger (Author)


If your dog has cancer, you need this book. No matter what you’ve heard, there are always steps you can take to help your dog fight (and even beat) cancer. This scientifically researched guide is your complete reference for practical, evidence-based strategies that can optimize the life quality and longevity for your dog. No matter what diagnosis or stage of cancer your dog has, this book is packed with precious advice that can help now. Discover the Full Spectrum approach to dog cancer care: Everything you need to know about conventional western veterinary treatments (surgery, chemotherapy and radiation) including how to reduce their side effects. The most effective non-conventional options, including botanical nutraceuticals, supplements, nutrition, and mind-body medicine. How to...

The 90 Day Canine Cancer Miracle: The 3 easy steps to treating cancer Inspired by 5 Time Nobel Peace Prize Nominee (Canine Cancer Treatments) (Volume 1)

The 90 Day Canine Cancer Miracle: The 3 easy steps to treating cancer Inspired by 5 Time Nobel Peace Prize Nominee (Canine Cancer Treatments) (Volume 1)
by Diana Gordon (Author)


The numbers are shocking: 50 percent of all dogs over the age of 10 will develop cancer and approximately one in two dogs will at some stage in their life develop a cancer. But for your dog, cancer does not have to be a death sentence. Inside the 90 Day Canine Cancer Miracle you'll discover the Nobel Prize nominated solution for healing cancer in 90% of cases. Just look what a celebrated doctor had to say on this topic. “Cancer treatment can be very simple and very successful, once you know how. The cancer interests don’t want you to know this.” – Dr. Roem M.D. FAACP

My Dog Has Cancer. What Can I Do?: Nola's Wellness Guide & Journey with Holistic Medicine

My Dog Has Cancer. What Can I Do?: Nola's Wellness Guide & Journey with Holistic Medicine
by Heather Beuke Diers (Author)


While documenting Nola's journey with cancer and holistic medicine, I gathered information that can now guide you through every stage of your dog's cancer. After completing hundreds of hours of research and taking a great team of veterinarians' advice, I have created an economical, cancer-fighting and immune-building protocol, for any canine (or human!) fighting cancer. I explain how cancer works in the body and how to create a cancer-killing environment with, wait for it. . .Food! How you treat the body will affect the outcome -this thought should empower you! Although we were able to turn a “three-months-to-live” diagnosis into a year of great quality of life for our girl, I believe we could have prolonged her life even longer if we had started with the protocol with which we ended...

Dog Cancer: The Holistic Answer: A Step by Step Guide

Dog Cancer: The Holistic Answer: A Step by Step Guide
by Dr. Steven Eisen (Author)


When his 11-year-old Lhasa Apso, Fergie, was diagnosed with lymphoma, a deadly cancer, Dr. Steven Eisen decided not to rely on standard veterinary care but to apply his own specialist expertise to the case and to treat his dog holistically. He knew from his prior research that a skillfully tailored diet, plus natural supplements, would often achieve cures without the downsides of conventional medicine. His instincts were validated: Fergie was restored to health, confounding her vet’s prognosis that she would live no more than six weeks by surviving for almost two and a half years and reaching normal life expectancy for her breed. Dog Cancer: The Holistic Answer describes in detail the broad protocol Dr. Eisen used to rescue Fergie from her death sentence and explains how to customize...

The Dog Cancer Diet

The Dog Cancer Diet
by Maui Media LLC


If your dog has been diagnosed with cancer, he or she needs to start eating a special diet right away. "The Dog Cancer Diet" (Kindle edition) walks you step-by-step through the homemade recipe and how to make the change from your dog's current diet.

You will learn about:
* How to help your dog fight cancer with food
* Commercial Dog Foods & Cancer-Causing Carcinogens
* Water Quality & Cancer
* Why Grains & Sugars are Bad for Dogs with Cancer
* Important Dietary Supplements to Help Dogs with Cancer

The right foods--many of which you probably have in your home right now--can be powerful weapons for a dog with cancer. Putting your dog on the diet described in "The Dog Cancer Diet" will accomplish two things: 1) Fight Cancer - while no food...

The Natural Vet's Guide to Preventing and Treating Cancer in Dogs

The Natural Vet's Guide to Preventing and Treating Cancer in Dogs
by D.V.M. Shawn Messonnier (Author), Russell L. Blaylock M.D. (Foreword)


In this easy-to-use guide, Dr. Shawn Messonnier offers the latest research on both treating new diagnoses of cancer and preventing the disease before it takes the life of a beloved family pet. He details a program that includes complementary therapies such as antioxidants, herbal preparations, homeopathic remedies, raw food, glandular supplements, and acupuncture. He stresses that while no one therapy is right for every pet, boosting the immune system is an excellent complement to conventional therapies like radiation, chemotherapy, and surgery, as well as an important preventive program for healthy dogs. Presenting the reader with clinical studies supporting these treatments, or with his own extensive clinical experience where studies are not yet available, Dr. Messonnier gives readers...

Canine Cancer

Canine Cancer
by Dogwise Publishing


Cancer cannot be cured through diet alone, but diet does play a significant role. Food is a wonderful motivator and by providing home-prepared meals, the dog's attitude is often greatly improved. High-quality ingredients are equally important. Also discusses cancer-related dietary myths.

42 Rules to Fight Dog Cancer (2nd Edition): Real Stories and Practical Approaches to Dealing with Dog Cancer

42 Rules to Fight Dog Cancer (2nd Edition): Real Stories and Practical Approaches to Dealing with Dog Cancer
by Aimee Quemuel (Author)


You just heard the words no dog owner ever wants to hear ... your dog has cancer. Suddenly you are faced with making a frenzy of life and death decisions for your beloved friend, while fighting back the tears. Should I do chemo? What about holistic medicine? What about surgery? Do I change his diet? Organic or medicinal? Should I euthanize? Experts predict that half of all dogs will get some type of cancer in their lifetimes with 80 percent of dogs over the age of 10 dying from the disease. The grim statistics go on and on. But the good news is that for every dog that passes away, there are thousands of stories of survival yet to be told. "42 Rules to Fight Dog Cancer (2nd Edition)" is a compilation of real stories, told by real people about their successful battle against dog cancer....

Final Journey: Buddys' Book

Final Journey: Buddys' Book
by Elizabeth Parker (Author)


(Sequel to Finally Home) There are many books about dogs, but it's difficult to find one that describes what it is like to grieve the loss of a dog. After the publication of "Finally Home," Buddy was diagnosed with terminal cancer. Once the unthinkable happened and Buddy's precious life was cut short, his family was left heartbroken and devastated. At the same time, in another state, poor economic conditions forced another family to give up their golden retriever. As fate would have it, his name...was Buddy. While they were mourning the loss of their beloved dog, another dog was mourning the loss of his treasured family. Brought together by misfortune, they entered each other's lives to help put back together the pieces of their broken hearts. This dog lover's book is for both Buddys,...

  Managing the Canine Cancer Patient: A Practical Guide to Compassionate Care
by Gregory K. Ogilvie (Author), Antony S. Moore (Author)


gently used. clean pages.

© 2016 BrightSurf.com