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Study drug holds promise as alternative to castration for early prostate cancers
August 23, 2006For those unwilling to undergo chemical castration however, results of an international study led by a Medical College of Wisconsin researcher show promise for an oral drug as an alternative. The study appears in the August issue of the Journal of Cancer Research and Clinical Oncology.
"In patients with locally-advanced disease, a daily 150 mg dose of bicalutamide, (Casodex TM) following initial radiotherapy, has shown significant clinical benefits in terms of overall survival and progression-free survival, compared with radiotherapy alone," says study author William A See, M.D., chairman and professor of urology at the Medical College in Milwaukee, and chief of urologic surgery at Froedtert Hospital.
The double-blind, randomized study followed 1,370 early prostate cancer patients in the U.S., Sweden and Europe who received radiotherapy with curative intent. After a median follow-up of 7.2 years, the researchers found that those receiving a daily, 150 mg oral dose of Casodex TM reduced their risk of disease progression by 44 percent, and their overall risk of death by 35 percent, compared to those receiving a placebo. "Although many of the adverse effects of castration therapy are manageable, they can have a detrimental effect on quality of life," says Dr. See "Here we have evaluated the efficacy and tolerability of a non-castration-based therapy, and found the survival rates to be similar."
Medical College of Wisconsin
Medical College of Wisconsin
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Drug shows activity in men with advanced prostate cancer
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Why prostate cancer patients fail hormone deprivation therapy
The hormone deprivation therapy that prostate cancer patients often take gives them only a temporary fix, with tumors usually regaining their hold within a couple of years.
Prostate cancer patients undergoing hormone therapy may experience cognitive effects
A recent review of the literature has found that hormone deprivation therapy, a commonly used treatment for prostate cancer, may have subtle adverse effects on cognition in patients-- such as in the ability to recall and concentrate.
Prostate cancer vaccines more effective with hormone therapy
Among patients with castration-resistant prostate cancer, the addition of hormone therapy following vaccine treatment improved overall survival compared with either treatment alone or when the vaccine followed hormone treatment, according to recent data published in the July 15 Clinical Cancer Research, a journal of the American Association for Cancer Research.
Counting tumor cells in blood predicts treatment benefit in prostate cancer
Counting the number of tumor cells circulating in the bloodstream of patients with castration-resistant prostate cancer can accurately predict how well they are responding to treatment, new results show.
How advanced prostate cancer becomes resistant to androgen-deprivation therapy
For the past 70 years the treatment of choice for advanced, metastatic prostate cancer has been androgen-deprivation therapy.
New research may show why some prostate cancer recurs after treatment
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Durvet Ideal Castration Ring Applicator - 2008 by DURVET IDEAL Easy-to-use instrument designed for one-person operation of castrating lambs, calves, goats and other animals.This instrument may also be used for docking and prolapses.Used for the application of the latex castrating bands.Plastic handle with metal prongs.Dimensions (L x W x H):12 x 6 x 1 |
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