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Researchers discover gut tissue to be a major reservoir harboring HIV

August 28, 2006

FINDINGS: UCLA researchers have found the human gut to be a major reservoir harboring the HIV virus - holding almost twice as much as a person's blood. In addition, the virus stored in the gut does not decay or reduce over time, as is also the case with blood-related reservoirs. It is well-known that peripheral blood mononuclear cells (PBMCs) and lymph nodes are principal reservoirs harboring the human immunodeficiency virus (HIV). The role of gut-associated lymphoid tissue (GALT) in this setting, however, had not been properly evaluated until now. Researchers from the Center for Prevention Research and the UCLA AIDS Institute at the David Geffen School of Medicine at UCLA, in collaboration with the AIDS Research Alliance in West Hollywood, Calif., collaborated on this research.

IMPACT: The findings further confirm that HIV remains persistent and elusive, and that eradicating the virus using current anti-retroviral therapy alone is not enough. Despite using fully suppressive therapy, patients in the study still had evidence of persistent, steady levels of HIV in gut tissue as well as in the blood.





University of California-Los Angeles



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Title: Rapid absorbing gut suture versus 2-octylethylcyanoacrylate tissue adhesive in the epidermal closure of linear repairs.(ORIGINAL ARTICLES)(Clinical report)
Author: Emily P. Tierney
Publication: Journal of Drugs in Dermatology (Magazine/Journal)
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Description:
Whole body metal concentration is easier to analyse than concentration in tissues, but is often not an accurate measure of the potential toxicity of the metal. We tested if whole body metal and metalloid concentrations in the caddisfly Hydropsyche (Trichoptera, Hydropsychidae), common in a mine-polluted river (Guadiamar River, SW Spain), were a useful measure to extrapolate environmental degradation. Our results confirmed that metal and metalloid accumulation by Hydropsyche strongly correlated...

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