Science Current Events | Science News | Brightsurf.com
 

Case and Cleveland Clinic researchers identify molecule in age-related macular degeneration

September 07, 2006
CLEVELAND-A dart-like molecule that adheres to proteins in the eye is the key that turns on the uncontrolled growth of blood vessels, according to researchers at Case Western Reserve University and the Cleveland Clinic Cole Eye Institute. Uncontrolled blood vessel growth is a major contributor to the development of age-related macular degeneration (AMD), the leading cause of blindness among people over 65 in the United States.

Robert Salomon and his graduate students Kutralanathan Renganathan and Liang Lu of Case's Department of Chemistry in the College of Arts and Sciences, found that the molecule, Carboxyethylpyrroles (CEPs), attaches to proteins found in the eye, triggering the uncontrolled growth of blood cells.

The Case researchers teamed up with Quteba Ebrahem Jonathan Sears, Amit Vasanji, John Crabb and Bela Anand-Apte and Xiaorong Gu (a Salomon group alumna), of Cleveland Clinic, to complete the study titled Carboxyethlpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration."

The results of their collaborative work were published in the recent Proceedings of the National Academy of Science (PNAS).

AMD is a progressive disease that results in the severe loss of vision. The early stages of AMD are characterized as "dry," with the disease advancing to the "wet form" as the retina, the part of the eye responsible for central vision, becomes infused with fluid from leaky new blood vessels, during a process called neovascularization. The unchecked blood vessel growth, or angiogenesis, in the retina accounts for 80% of the vision loss in the advanced stages of AMD.

The retina cells that detect light contain polyunsaturated fatty lipids that are exquisitely sensitive to damage by oxygen. Even in healthy eyes, these cells are renewed every ten days. The researchers at Case and Cleveland Clinic used a method developed by Salomon to specifically detect and measure the amount of CEPs found in the eye.

The researchers did in vivo animal studies with membranes from chicken eggs and rat eyes and found that CEPs attached to proteins induce angiogenesis. They also found that the protein part of CEP-protein adducts is not important for producing the growth of the blood vessels. Rather, the actual CEP is the cause of angiogenesis.

In an attempt to block CEP from triggering the angiogenesis process, "we are now trying to find the receptors - the keyholes - in the retina cells that are activated by CEPs," said Salomon. "We are also designing drugs that can mop up the CEPs or prevent their formation.\\\

Case Western Reserve University


Related Macular Degeneration Current Events and Macular Degeneration News Articles


New discoveries in age-related macular degeneration revealed in industry and academia
Insilico Medicine along with scientists from Vision Genomics and Howard University shed light on AMD disease, introducing the opportunity for eventual diagnostic and treatment options.

Top-selling eye vitamins found not to match scientific evidence
With Americans spending billions of dollars each year on nutritional supplements, researchers have analyzed popular eye vitamins to determine whether their formulations and claims are consistent with scientific findings.

Teleophthalmology for screening, recurrence of age-related macular degeneration
No relevant delay between referral and treatment was found when teleophthalmology was used to screen for suspected age-related macular degeneration (AMD) and, while teleophthalmology monitoring for recurrence of AMD did result in an average longer wait time for treatment reinitiation, it did not result in worse visual outcomes.

Nanotubes May Restore Sight to Blind Retinas
The aging process affects everything from cardiovascular function to memory to sexuality. Most worrisome for many, however, is the potential loss of eyesight due to retinal degeneration.

The human eye can see 'invisible' infrared light
Any science textbook will tell you we can't see infrared light. Like X-rays and radio waves, infrared light waves are outside the visual spectrum.

University of Kentucky reports HIV/AIDS drugs could be repurposed to treat AMD
A landmark study published today in the journal Science by an international group of scientists, led by the laboratory of Dr. Jayakrishna Ambati, professor & vice chair of the Department of Ophthalmology & Visual Sciences at the University of Kentucky, reports that HIV/AIDS drugs that have been used for the last 30 years could be repurposed to treat age-related macular degeneration (AMD), as well as other inflammatory disorders, because of a previously undiscovered intrinsic and inflammatory activity those drugs possess.

New insight into common cause of blindness
Scientists at The University of Manchester have identified an important new factor behind one of the major causes of blindness, which they hope could lead to new treatments.

Artificial retina could someday help restore vision
The loss of eyesight, often caused by retinal degeneration, is a life-altering health issue for many people, especially as they age.

Researchers find novel approach to treating number 1 cause of blindness in elderly
While oxygen is essential to our planet's life force and the way we function and stay healthy, high concentrations referred to as oxidative stress may very well be the cause of more than 70 widely-spread diseases such as cancer, heart disease, neurodegenerative diseases, and eye diseases including macular degeneration.

Molecular breakthrough could halt the spread of prostate cancer
Scientists believe a new treatment, shown to be effective in mice, could halt the growth of tumours in patients with prostate cancer.
More Macular Degeneration Current Events and Macular Degeneration News Articles

Overcoming Macular Degeneration: A Guide to Seeing Beyond the Clouds

Overcoming Macular Degeneration: A Guide to Seeing Beyond the Clouds
by J.D. Solomon (Contributor)


Each year, more than 400,000 Americans are diagnosed with macular degeneration, an age-related, progressive eye disease that immediately raises a fear of total blindness. The good news is: YOU ARE NOT GOING BLIND. However, you are dealing with a disease that causes serious visual impairment—an inconvenience the author, Dr. Yale Solomon, is personally familiar with because he has macular degeneration. Now this respected ophthalmologist offers a compassionate and understanding look at both the medical and human side of macular degeneration and ways to meet the challenge of its impact on everyday life. This newly updated edition includes a comprehensive appendix of associations, organizations and foundations, large-print publishers, audio and video resources, and a helpful list of...

Macular Degeneration: The Complete Guide to Saving and Maximizing Your Sight

Macular Degeneration: The Complete Guide to Saving and Maximizing Your Sight
by Lylas G. Mogk (Author), Marja Mogk (Author)


The acclaimed book on macular degeneration—now completely revised and updated with cutting edge research and the latest developments in the field.

More than fifteen million Americans have age-related macular degeneration (AMD), and the disease will strike 200,000 more people this year. It is the most prevalent cause of vision loss in the western world. Dr. Lylas Mogk, the founding director of the Visual Rehabilitation and Research Center of the Henry Ford Health System, has a unique professional and personal understanding of AMD. A doctor and loving daughter of a parent with this frightening though manageable condition, Mogk here explains exactly what it is and how to limit its effect on your life. Reassuring and comprehensive—complete with illuminating first person stories of...

Macular Degeneration... ...Macular Regeneration (Natural Vision & Eye Care) (Volume 3)

Macular Degeneration... ...Macular Regeneration (Natural Vision & Eye Care) (Volume 3)
by Dr. Glen Swartwout (Author)


When asked, the one thing most people would least want to lose is their vision. Macular Degeneration is particularly frustrating, because it affects the central vision, so that whatever you look at is distorted or even disappears in a black hole... While recent announcements in the news have brought hope to millions that stem cell injections deep into the eye have now been observed to stimulate regeneration of the macula, potentially restoring functional vision to those blinded by this common condition, the methods outlined in detail in this book have stimulated this kind of healing as well, without any invasive procedures. Such results have been observed independently by two different Harvard trained retinal specialists following Dr. Swartwout's patients after they chose to pursue...

Macular Disease: Practical Strategies for Living with Vision Loss

Macular Disease: Practical Strategies for Living with Vision Loss
by Peggy R. Wolfe (Author)


Filled with compiling ideas for living well with vision loss from macular disease, this book's positive, take-charge approach provides encouragement to both the newly diagnosed and those at later stages of their disease by showing ways to compensate for their declining sight. Featuring photos of special lighting and other aids and insight from the author's own personal experience with low vision, this oversized handbook is ideally formatted for readers with vision loss by employing the use of large print on glare-resistant paper. Offering reassurance, hope, and personal insight, this revised edition is filled with descriptions of adaptive strategies and assistive technologies. With strong endorsements from medical communities, the book includes an invaluable index and resource list for...

The First Year: Age-Related Macular Degeneration: An Essential Guide for the Newly Diagnosed

The First Year: Age-Related Macular Degeneration: An Essential Guide for the Newly Diagnosed
by Daniel L. Roberts (Author)


Age-related macular degeneration (AMD) is a progressive disease of the retina wherein the light-sensing cells in the central area of vision (the macula) stop working and eventually die. AMD is the leading cause of legal blindness in people over 50. From the moment of his own diagnosis, educator and musician Dan Roberts has made it his mission to provide the most up-to-date information about AMD, its effects and challenges, through his website at mdsupport.org. Receiving over 60,000 unique visitors monthly, MD Support is the go-to for all things AMD. Now, as a "patient-expert," Roberts applies his wealth of knowledge to the First Year series, providing crucial information for the newly diagnosed, including cutting edge therapies, and tips on how to navigate everyday tasks with diminishing...

Living With Macular Degeneration: What Your Doctors Cannot Tell You

Living With Macular Degeneration: What Your Doctors Cannot Tell You
by Edgar C Craddick (Author), Benjamin Joel Michaelis (Illustrator)


Living With Macular Degeneration is a guide born of experience. Ed Craddick shares with the reader his love of life throughout his trials and travails with the progressive condition, Age-related Macular Degeneration.

Macular Degeneration: A Complete Guide for Patients and Their Families

Macular Degeneration: A Complete Guide for Patients and Their Families
by Michael A. Samuel (Author)


For people who start losing their vision to macular degeneration, the prospect of impending blindness is frightening and terribly depressing. They often get contradictory advice about surgery, medical treatments, natural supplements, and lifestyle changes that might arrest or reverse the condition, and these conflicting recommendations only compound their anxiety.

Finally, in Macular Degeneration: A Complete Guide for Patients and Their Families, patients and their loved ones can turn to one easy-to-understand and authoritative source for up-to-date information about macular degeneration. Written by renowned ophthalmologist Michael Samuel, M.D., a retinal specialist, this book casts the spotlight on macular degeneration and dispels the myths surrounding this disease.

Macular...

Stem Cells Heal Your Eyes: Prevent and Help: Macular Degeneration, Retinitis Pigmentosa, Stargardt, Retinal Distrophy, and Retinopathy.

Stem Cells Heal Your Eyes: Prevent and Help: Macular Degeneration, Retinitis Pigmentosa, Stargardt, Retinal Distrophy, and Retinopathy.
by Carlyle Coash MA (Author), Adam Miller (Author), Damon P Miller II MD (Author)


A physician and pioneer in the integrative treatment of serious eye diseases such as Macular Degeneration, Retinitis Pigmentosa, Stargardt and other retinopathies reveals the best strategies used today to prevent and reverse these devastating diseases. Drawing on some of the hottest topics in modern medicine, the book discusses the surprising revelations from the research in Epigenetics and adult stem cells. Your genes are not your destiny. From our work with thousands of people, we understand that you might be fearful that you will lose your independence or your ability to do even the simplest tasks because serious eye disease is taking your sight. This book empowers you with simple tools that combat degenerative eye disease. Tools that support a healthy lifestyle and methods to remove...

The Macular Degeneration Handbook: Natural Ways to Prevent & Reverse It

The Macular Degeneration Handbook: Natural Ways to Prevent & Reverse It
by Chet Cunningham (Author)


Those who suffer from Macular Degeneration or other degenerative eye diseases including Cataracts, Lacoma, Retinitis Pigmentosa and eye diseases associated with diabetes can benefit from this book. Readers learn symptoms, causes, treatments and prevention strategies using all-natural and alternative methods. The book shows how nutrition, dietary supplements, exercises and other methods can bring relief.

Reverse Your Macular Degeneration: Secrets to Reversing Your Macular Disease Naturally in as Little as 30 Days

Reverse Your Macular Degeneration: Secrets to Reversing Your Macular Disease Naturally in as Little as 30 Days
by Eye Disorders


David Smith's Reverse Your Macular Degeneration reveals the truth about saving and maximizing your vision naturally. This unique book guides you step by step to the safest and easiest ways to preserve your sight and achieve remarkable vision improvement within a short period of time.

Inside you'll discover...

--The Truth About Macular Degeneration

--The Macular Degeneration Diet

--The Facts About Antioxidants and Vision Improvement

--A Radical New Way to Look at Carotenes

--Fats: The Unlikely Healers

--The Power of Fish

--The Surprising New Discovery About Being Fat

--Little Changes That Slow Down Macular Degeneration Right Now

--Almost-Magical Nutrients for Macular...

© 2014 BrightSurf.com