Science Current Events | Science News | Brightsurf.com
 

Case and Cleveland Clinic researchers identify molecule in age-related macular degeneration

September 07, 2006
CLEVELAND-A dart-like molecule that adheres to proteins in the eye is the key that turns on the uncontrolled growth of blood vessels, according to researchers at Case Western Reserve University and the Cleveland Clinic Cole Eye Institute. Uncontrolled blood vessel growth is a major contributor to the development of age-related macular degeneration (AMD), the leading cause of blindness among people over 65 in the United States.

Robert Salomon and his graduate students Kutralanathan Renganathan and Liang Lu of Case's Department of Chemistry in the College of Arts and Sciences, found that the molecule, Carboxyethylpyrroles (CEPs), attaches to proteins found in the eye, triggering the uncontrolled growth of blood cells.

The Case researchers teamed up with Quteba Ebrahem Jonathan Sears, Amit Vasanji, John Crabb and Bela Anand-Apte and Xiaorong Gu (a Salomon group alumna), of Cleveland Clinic, to complete the study titled Carboxyethlpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration."

The results of their collaborative work were published in the recent Proceedings of the National Academy of Science (PNAS).

AMD is a progressive disease that results in the severe loss of vision. The early stages of AMD are characterized as "dry," with the disease advancing to the "wet form" as the retina, the part of the eye responsible for central vision, becomes infused with fluid from leaky new blood vessels, during a process called neovascularization. The unchecked blood vessel growth, or angiogenesis, in the retina accounts for 80% of the vision loss in the advanced stages of AMD.

The retina cells that detect light contain polyunsaturated fatty lipids that are exquisitely sensitive to damage by oxygen. Even in healthy eyes, these cells are renewed every ten days. The researchers at Case and Cleveland Clinic used a method developed by Salomon to specifically detect and measure the amount of CEPs found in the eye.

The researchers did in vivo animal studies with membranes from chicken eggs and rat eyes and found that CEPs attached to proteins induce angiogenesis. They also found that the protein part of CEP-protein adducts is not important for producing the growth of the blood vessels. Rather, the actual CEP is the cause of angiogenesis.

In an attempt to block CEP from triggering the angiogenesis process, "we are now trying to find the receptors - the keyholes - in the retina cells that are activated by CEPs," said Salomon. "We are also designing drugs that can mop up the CEPs or prevent their formation.\\\

Case Western Reserve University


Related Macular Degeneration Current Events and Macular Degeneration News Articles


Age-related macular degeneration occurs much earlier than previously assumed
It is widely accepted that age-related macular degeneration (AMD) is the most common cause of visual impairment and blindness in industrialized countries.

Depression in AMD patients with low vision can be halved by integrated therapies
The first clinical trial to examine integrated low vision and mental health treatment has shown that the approach can reduce the incidence of depression by half among people with low vision due to age-related macular degeneration (AMD).

Rehabilitation helps prevent depression from age-related vision loss
Depression is a common risk for people who have lost their vision from age-related macular degeneration (AMD), but a new study shows that a type of rehabilitation therapy can cut this risk in half. The study was funded by the National Eye Institute (NEI), part of the National Institutes of Health.

Fox Chase doctors urge caution over new analysis of Medicare payments
There's much to learn from the recent release of unprecedented amounts of data from the nation's second largest health insurer, Medicare, but only if interpreted cautiously, write two doctors at Fox Chase Cancer Center in the June 9 online edition of the Annals of Internal Medicine.

Grape-enriched diet supports eye health
New research presented this week at the Association for Research in Vision and Ophthalmology conference in Orlando, Florida suggests that regular grape consumption may play a role in eye health by protecting the retina from deterioration.

Long-term daily multivitamin supplement use decreases cataract risk in men
Long-term daily multivitamin supplement use may lower cataract risk in men, according to a study of nearly 15,000 male physicians published this month in Ophthalmology, the journal of the American Academy of Ophthalmology.

Researchers collaborate to reduce effects of the aging eye
Aging gracefully may not be an option for the 40 million people worldwide who are blind or have significant visual impairment.

Orbital samples with sight-saving potential
Those who travel to space are rewarded with a beautiful sight - planet Earth. But the effects of space travel on the human sense of sight aren't so beautiful.

SIRT5 Regulation Has Dramatic Effect on Mitochondrial Metabolism
The Sirtuin family of protein deacylases has received considerable attention in recent years due to its links to longevity, diabetes, cancer, and metabolic regulation.

Methylation signaling controls angiogenesis and cancer growth
A study led by researchers at Boston University School of Medicine (BUSM) demonstrates a new mechanism involving a signaling protein and its receptor that may block the formation of new blood vessels and cancer growth.
More Macular Degeneration Current Events and Macular Degeneration News Articles

Overcoming Macular Degeneration: A Guide to Seeing Beyond the Clouds

Overcoming Macular Degeneration: A Guide to Seeing Beyond the Clouds
by J.D. Solomon (Contributor)


Each year, more than 400,000 Americans are diagnosed with macular degeneration, an age-related, progressive eye disease that immediately raises a fear of total blindness. The good news is: YOU ARE NOT GOING BLIND. However, you are dealing with a disease that causes serious visual impairment—an inconvenience the author, Dr. Yale Solomon, is personally familiar with because he has macular degeneration. Now this respected ophthalmologist offers a compassionate and understanding look at both the medical and human side of macular degeneration and ways to meet the challenge of its impact on everyday life. This newly updated edition includes a comprehensive appendix of associations, organizations and foundations, large-print publishers, audio and video resources, and a helpful list of...

Macular Degeneration: From Diagnosis to Treatment

Macular Degeneration: From Diagnosis to Treatment
by David S. Boyer MD (Author), Homayoun Tabandeh MD (Author)


With a focus on giving those diagnosed with macular degeneration the necessary information to make sound treatment choices, this reference aims to answer patients’ questions and ease their anxiety. The book provides information on the symptoms, causes, and emotional impact of macular degeneration; how the disease is diagnosed; choosing the right physician; and how to adapt the home and workplace to be “eye friendly.” In addition, it outlines the newest treatment options, drugs and surgical techniques, ways to slow the progression of the disease, and the importance of nutrition and general fitness on eye health. Written by two doctors with decades of experience treating thousands of patients, it supplies essential facts while affirming that people living with the disease can still...

The First Year: Age-Related Macular Degeneration: An Essential Guide for the Newly Diagnosed

The First Year: Age-Related Macular Degeneration: An Essential Guide for the Newly Diagnosed
by Daniel L. Roberts (Author)


Age-related macular degeneration (AMD) is a progressive disease of the retina wherein the light-sensing cells in the central area of vision (the macula) stop working and eventually die. AMD is the leading cause of legal blindness in people over 50. From the moment of his own diagnosis, educator and musician Dan Roberts has made it his mission to provide the most up-to-date information about AMD, its effects and challenges, through his website at mdsupport.org. Receiving over 60,000 unique visitors monthly, MD Support is the go-to for all things AMD. Now, as a "patient-expert," Roberts applies his wealth of knowledge to the First Year series, providing crucial information for the newly diagnosed, including cutting edge therapies, and tips on how to navigate everyday tasks with diminishing...

Macular Degeneration: The Complete Guide to Saving and Maximizing Your Sight

Macular Degeneration: The Complete Guide to Saving and Maximizing Your Sight
by Lylas G. Mogk (Author), Marja Mogk (Author)


The acclaimed book on macular degeneration—now completely revised and updated with cutting edge research and the latest developments in the field.

More than fifteen million Americans have age-related macular degeneration (AMD), and the disease will strike 200,000 more people this year. It is the most prevalent cause of vision loss in the western world. Dr. Lylas Mogk, the founding director of the Visual Rehabilitation and Research Center of the Henry Ford Health System, has a unique professional and personal understanding of AMD. A doctor and loving daughter of a parent with this frightening though manageable condition, Mogk here explains exactly what it is and how to limit its effect on your life. Reassuring and comprehensive—complete with illuminating first person stories of...

Macular Disease: Practical Strategies for Living with Vision Loss

Macular Disease: Practical Strategies for Living with Vision Loss
by Peggy R. Wolfe (Author)


Filled with compiling ideas for living well with vision loss from macular disease, this book's positive, take-charge approach provides encouragement to both the newly diagnosed and those at later stages of their disease by showing ways to compensate for their declining sight. Featuring photos of special lighting and other aids and insight from the author's own personal experience with low vision, this oversized handbook is ideally formatted for readers with vision loss by employing the use of large print on glare-resistant paper. Offering reassurance, hope, and personal insight, this revised edition is filled with descriptions of adaptive strategies and assistive technologies. With strong endorsements from medical communities, the book includes an invaluable index and resource list for...

Reverse Your Macular Degeneration: Secrets to Reversing Your Macular Disease Naturally in as Little as 30 Days

Reverse Your Macular Degeneration: Secrets to Reversing Your Macular Disease Naturally in as Little as 30 Days
by Eye Disorders


David Smith's Reverse Your Macular Degeneration reveals the truth about saving and maximizing your vision naturally. This unique book guides you step by step to the safest and easiest ways to preserve your sight and achieve remarkable vision improvement within a short period of time.

Inside you'll discover...

--The Truth About Macular Degeneration

--The Macular Degeneration Diet

--The Facts About Antioxidants and Vision Improvement

--A Radical New Way to Look at Carotenes

--Fats: The Unlikely Healers

--The Power of Fish

--The Surprising New Discovery About Being Fat

--Little Changes That Slow Down Macular Degeneration Right Now

--Almost-Magical Nutrients for Macular...

Macular Degeneration: A Complete Guide for Patients and Their Families

Macular Degeneration: A Complete Guide for Patients and Their Families
by Michael A. Samuel (Author)


For people who start losing their vision to macular degeneration, the prospect of impending blindness is frightening and terribly depressing. They often get contradictory advice about surgery, medical treatments, natural supplements, and lifestyle changes that might arrest or reverse the condition, and these conflicting recommendations only compound their anxiety.

Finally, in Macular Degeneration: A Complete Guide for Patients and Their Families, patients and their loved ones can turn to one easy-to-understand and authoritative source for up-to-date information about macular degeneration. Written by renowned ophthalmologist Michael Samuel, M.D., a retinal specialist, this book casts the spotlight on macular degeneration and dispels the myths surrounding this disease.

Macular...

Macular Degeneration: The Latest Scientific Discoveries and Treatments for Preserving Your Sight

Macular Degeneration: The Latest Scientific Discoveries and Treatments for Preserving Your Sight
by Robert D'Amato M.D. Ph.D. (Author), Joan Snyder (Author)


Dr. Robert D'Amato, MD, PhD of Harvard Medical School,and recent winner of the Lew Wasserman award for his pioneering eye research, has teamed up with ARMD sufferer and writer Joan Snyder, to produce Macular Degeneration: The Latest Scientific Discoveries and Treatments for Preserving Your Sight. Endorsed by the Macular Degeneration Foundation, this easy-to-read large type edition is the only book written for laymen that covers all of the latest scientific discoveries and promising research for age-related macular degeneration. Learn more about Visudyne (photodynamic therapy), laser therapy, nutrition and drug therapy. Dr. D'Amato covers alternative or complimentaty therapies such as acupuncture, meditation, microcurrent stimulation and more. Promising medical research initiatives are...

Living With Macular Degeneration: What Your Doctors Cannot Tell You

Living With Macular Degeneration: What Your Doctors Cannot Tell You
by Edgar C Craddick (Author), Benjamin Joel Michaelis (Illustrator)


Living With Macular Degeneration is a guide born of experience. Ed Craddick shares with the reader his love of life throughout his trials and travails with the progressive condition, Age-related Macular Degeneration.

My Friend, You Are Legally Blind A Writer's Struggle with Macular Degeneration

My Friend, You Are Legally Blind A Writer's Struggle with Macular Degeneration
by Charles Champlin (Author)


Book by Champlin, Charles

© 2014 BrightSurf.com