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Cold Spring Harbor Protocols features methods for analyzing protein interactions
September 11, 2006Cold Spring Harbor Protocols, an online journal that publishes methods used in a wide range of biology laboratories, has added over 40 new peer-reviewed protocols to its archive today. The new collection highlights two techniques for characterizing protein interactions, which will aid many cell and molecular biologists-including those who seek to identify the molecular basis of human diseases. Both of these methods are freely accessible from the journal's website: http://www.cshprotocols.org
Given the importance of characterizing the molecular networks and signaling pathways that form the biological basis of all living organisms, techniques aimed at probing protein interactions have come to the forefront in recent years. The new methods published today by CSH Protocols will be useful for researchers seeking to identify the molecular partners-such as other proteins or DNA-to which specific proteins bind.
The latest issue of CSH Protocols also includes a variety of other standard and specialized techniques that will be useful to many researchers. These include methods for synchronizing cell growth, investigating embryonic development, and preparing specimens for immunostaining.
Cold Spring Harbor Laboratory
Protein Interaction Current Events and Protein Interaction News RSSAileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Protein interaction network can respond Helicobacter pylori infection?
Helicobacter pylori (H pylori) is a gram negative bacterium which infects about 50% of the world population. H pylori colonization causes a strong systemic immune response.
LincRNAs serve as genetic air-traffic controllers
Earlier this year, a scientific team from Beth Israel Deaconess Medical Center (BIDMC) and the Broad Institute identified a class of RNA genes known as large intervening non-coding RNAs or "lincRNAs," a discovery that has pushed the field forward in understanding the roles of these molecules in many biological processes, including stem cell pluripotency, cell cycle regulation, and the innate immune response.
GUMC discovery highlights new direction for drug discovery
In a discovery that rebuffs conventional scientific thinking, researchers at Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare cancer found in children and young adults.
Small molecules mimic natural gene regulators
In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.
Protein-protein interaction explains vision loss in genetic diseases
The mystery of genetic disease is only partially solved with the identification of a mutated gene. Often, the pattern of disease - the features or disorders associated with it - vary in type and severity among those who are affected. Scientists, physicians and patients all ask why.
A new mechanism regulates type I interferon production in white blood cells
A study from a team of researchers led by Dr. Andrew P. Makrigiannis, Director of the Molecular Immunology Research Unit at the IRCM, has identified a new mechanism regulating interferon production.
What's the difference between a human and a fruit fly?
Fruit flies are dramatically different from humans not in their number of genes, but in the number of protein interactions in their bodies, according to scientists who have developed a new way of estimating the total number of interactions between proteins in any organism.
In lab study, researchers find molecule that disrupts Ewing's sarcoma oncogene
Researchers at Georgetown University Medical Center have found a small molecule they say can block the action of the oncogene that causes Ewing's sarcoma, a rare cancer found in children and young adults. If further studies continue to prove beneficial, they say the novel agent could be the first targeted therapy to treat the disease, which can produce tumors anywhere in the body.
Spit tests may soon replace many blood tests
One day soon patients may spit in a cup, instead of bracing for a needle prick, when being tested for cancer, heart disease or diabetes. A major step in that direction is the cataloguing of the "complete" salivary proteome, a set of proteins in human ductal saliva, identified by a consortium of three research teams.
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DNA-Protein Interactions: Principles and Protocols, Third Edition (Methods in Molecular Biology) by Tom Moss (Editor), Benoît Leblanc (Editor) Gene expression can mean the difference between a functional and non-functional genome, between health and disease, and with the development of transgenic crops, the difference between survival and starvation. In DNA-Protein Interactions: Principles and Protocols, Third Edition, this vital subject is brought up to date with protocols exploring the most cutting-edge developments in the field, including in vivo and genome-wide interaction techniques. Addressing topics such as chromatin immunoprecipitation, topological studies, photocrosslinking, FRET and imaging techniques, the volume fully updates and expands upon the successful previous editions. Written in the convenient and informative Methods in Molecular Biology™ series format, chapters include introductions to their respective... |
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Protein-Dna Interaction Framed Art Poster Print by Jacob Halaska, 39x31 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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Protein-Nucleic Acid Interactions: Structural Biology (RSC Biomolecular Sciences) by Phoebe A. Rice (Author), Phoebe A. Rice (Editor), Carl C. Correll (Editor) This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions It will be a key reference for both advanced students and established scientists wishing to broaden their horizons. |
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Protein'Protein Interactions: Methods and Applications (Methods in Molecular Biology) by Haian Fu (Editor) Emory Univ., Atlanta, GA. Describes in detail biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions as they occur in living cells. Offers step-by-step laboratory instructions. For researchers. DNLM: Protein Binding--physiology--Laboratory Manuals. |
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RNA-Protein Interaction Protocols (Methods in Molecular Biology) by Ren-Jang Lin (Editor) Due to the vital biological importance of RNA and proteins functioning together within a cell, a protocol volume describing experimental procedures to study their interactions should find a home in many laboratories. RNA-Protein Interaction Protocols, Second Edition updates, complements, and expands upon the popular first edition by providing a collection of cutting-edge techniques developed or refined in the past few years along with tried-and-true methods. The expert contributors explore the isolation and characterization of RNA-protein complexes, the analysis and measurement of RNA-protein interaction, and related novel techniques and strategies. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include brief introductions to the material,... |
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Protein-Dna Interaction Framed Art Poster Print by Jacob Halaska, 31x25 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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Protein Structure, Stability, and Interactions (Methods in Molecular Biology) by John W. Shriver (Editor) In the areas of biochemistry and cell biology, characterizations of stability and molecular interactions call for a quantitative approach with a level of precision that matches the fine tuning of these interactions in a living cell. Supporting and up-dating previous Methods in Molecular Biology™ volumes, Protein Structure, Stability, and Interactions approaches its subject with a focus on theory and practical applications for both established methods as well as exciting new procedures. The volume presents an overview of many techniques currently used to study protein stability and interactions, including scanning and titration calorimetry, spectroscopic methods, high field NMR, and analytical ultracentrifugation. As a volume of the highly successful Methods in Molecular Biology™... |
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Prediction of Protein Structures, Functions, and Interactions by Janusz Bujnicki (Author) The growing flood of new experimental data generated by genome sequencing has provided an impetus for the development of automated methods for predicting the functions of proteins that have been deduced by sequence analysis and lack experimental characterization. Prediction of Protein Structures, Functions and Interactions presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use. Methods of modeling of individual proteins, prediction of their interactions, and docking of complexes are put in the context of predicting gene ontology (biological process, molecular function, and cellular component) and discussed in the light of their contribution to the emerging... |
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Protein-Dna Interaction Photographic Poster Print by Jacob Halaska, 64x48 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses by David A. Puleo (Editor), Rena Bizios (Editor) Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers... |
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