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Jefferson researchers find potential biomarket for heart failure
September 12, 2006(PHILADELPHIA) A team of cardiology researchers at Thomas Jefferson University has determined that GRK2, a protein that plays an important regulatory role in heart failure, is elevated in patients with failing hearts when compared to patients with normal heart function.
"These findings add to the growing evidence that GRK2 is a biomarker for heart failure," says Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia. Dr. Koch previously demonstrated that GRK2 is critically important in heart function. It is increased in failing human hearts and contributes to the loss of the heart's contractile strength during the development of heart failure.
White blood cells from 20 heart failure patients were compared with white blood cells from 30 patients who didn't have heart disease to determine the presence of the GRK2 protein. "We have confirmed that GRK2 in white blood cells is elevated in human patients with failing hearts when compared to subjects with normal left ventricular function," Dr. Mittal said. "The GRK2 levels in heart failure patients were three to four times higher."
"Future studies will compare GRK2 levels in heart failure patients treated with standard prescription drug and device therapy to test our hypothesis that GRK2 can be a surrogate marker for determination of a given patient's response to treatment," Dr. Koch explains.
Thomas Jefferson University
Heart Failure Current Events and Heart Failure News RSSCarvedilol shown to have unique characteristics among beta blockers
In a new study, researchers report that a class of heart medications called beta-blockers can have a helpful, or harmful, effect on the heart, depending on their molecular activity.
High Blood Pressure Easy to Miss in Children with Kidney Disease
Spot blood pressure readings in children with chronic kidney disease often fail to detect hypertension - even during doctor's office visits - increasing a child's risk for serious heart problems, according to research from Johns Hopkins Children's Center and other institutions. A report of the findings appears online in the Journal of American Society of Nephrology.
Inhibition of GRK2 is protective against acute cardiac stress injuries
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion.
Young athletes need dual screening tests for heart defects, study suggests
To best detect early signs of life-threatening heart defects in young athletes, screening programs should include both popular diagnostic tests, not just one of them, according to new research from heart experts at Johns Hopkins.
Protein changes in heart strengthen link between Alzheimer's disease and chronic heart failure
A team of U.S., Canadian and Italian scientists led by researchers at Johns Hopkins report evidence from studies in animals and humans supporting a link between Alzheimer's disease and chronic heart failure, two of the 10 leading causes of death in the United States.
Elevated biomarkers lead to diminished quality of life in heart attack patients post-discharge
Many heart attack patients have high levels of cardiac biomarkers in the blood for several months after leaving the hospital, with more shortness of breath and chest pain, according to a Henry Ford Hospital study.
Tiny particles can deliver antioxidant enzyme to injured heart cells
Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.
New study links vitamin D deficiency to cardiovascular disease and death
While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well - and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease.
When seconds count: Interventional radiology treatment for pulmonary embolism saves lives
Catheter-directed therapy or catheter-directed thrombolysis-an interventional radiology treatment that uses targeted image-guided drug delivery with specially designed catheters to dissolve dangerous blood clots in the lungs-saves lives and should be considered a first-line treatment option for massive pulmonary embolism, note researchers in the November Journal of Vascular and Interventional Radiology.
Texas Children's discharges first pediatric patient with implanted mechanical heart device
Texas Children's Hospital is the nation's first pediatric hospital to discharge a child while on an intracorporeal ventricular assist device (VAD), a feat previously accomplished only at adult institutions.
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Heart Failure Heart failure, also called congestive heart failure, is a condition in which the heart cannot pump enough oxygenated blood to meet the needs of the body?s other organs. The heart keeps pumping, but not as efficiently as a healthy heart. Usually, the loss in the heart?s pumping action is a symptom of an underlying heart problem. Heart failure affects nearly 5 million US adults. It is on the rise with an estimated 400,000 to 700,000 new cases each year. This talk will focus on the causes, symptoms, diagnosis and treatments available for heart failure, including current research findings from Stanford. |
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