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An advanced genetic diagnostic method for multiple myeloma
September 12, 2006A researcher at the University of Navarra, Borja Sáez Ochoa, has proposed a new genetic diagnostic method for multiple myeloma (MM), a type of bone marrow cancer, which permits the detection of this disease in earlier stages.
The dissertation of this biologist, produced in the Department of Genetics of the School of Sciences of the University of Navarra, and in the Institute of Human Genetics of the University Hospital of Schleswig-Holstein, en Kiel (Germany), is oriented towards the study of the genetic base of this cancer, and the posterior development of cytogenetic diagnostic strategies for the detection of alterations with prognostic value.
For this purpose, he has analyzed, by means of statistical methods, the cytogenetic changes in a group of patients with MM. This methodology has permitted the discovery of associations between specific chromosomal changes, and thus the description of a new classification of the disease. In addition, the technique of hybridization in situ with fluorescence allowed him to identify new recurrent genetic changes that are involved in the appearance of this pathology.
A disease associated with old age
Multiple myeloma is a disease which primarily affects persons above 60 years of age. In 2001 in Spain, 1716 new cases were detected, and 1554 patients with the disease died, with 20 of these in Navarra. According to Borja Sáez, with the new methods of diagnosis developed through this research project, such as the FISH and FICTION strategies, we will be able to detect genetic alterations rapidly and easily in the early stages of the disease, permitting its early diagnosis. In addition, he emphasized that these procedures will promote the description of molecular targets for future, more effective treatments of MM.
These new techniques for genetic diagnosis of MM are already being applied in 20 hospitals in Spain. And in a not too distant future, these tests will permit us to offer each patient a treatment adapted to the genetic modifications that he or she presents, which, while they may not provide a cure for the disease, will make it possible to transform it into a chronic and asymptomatic pathology.
Elhuyar Fundazioa
A disease associated with old age
Multiple myeloma is a disease which primarily affects persons above 60 years of age. In 2001 in Spain, 1716 new cases were detected, and 1554 patients with the disease died, with 20 of these in Navarra. According to Borja Sáez, with the new methods of diagnosis developed through this research project, such as the FISH and FICTION strategies, we will be able to detect genetic alterations rapidly and easily in the early stages of the disease, permitting its early diagnosis. In addition, he emphasized that these procedures will promote the description of molecular targets for future, more effective treatments of MM.
These new techniques for genetic diagnosis of MM are already being applied in 20 hospitals in Spain. And in a not too distant future, these tests will permit us to offer each patient a treatment adapted to the genetic modifications that he or she presents, which, while they may not provide a cure for the disease, will make it possible to transform it into a chronic and asymptomatic pathology.
Elhuyar Fundazioa
Multiple Myeloma Current Events and Multiple Myeloma News RSSCancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
Approved lymphoma drug shows promise in early tests against bone cancer
A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today in the International Journal of Cancer.
Experimental drug lets B cells live and lymphoma cells die
An investigative drug deprived non-Hodgkin lymphoma cells of their ability to survive too long and multiply too fast, according to an early study published recently in the journal Experimental Hematology.
Boron-based compounds trick a biomedical protein
Chemists and biologists have successfully demonstrated that specially synthesized boron compounds are readily accepted in biologically active enzymes, a move that, they say, is a proof of concept that could lead to new drug design strategies.
Mayo Clinic Proceedings: Common blood disorder may not be linked to as many serious diseases
A symptomless blood disorder, monoclonal gammopathy of undetermined significance, known as MGUS, is not linked to as many serious diseases as previously thought.
New study suggests possible genetic links between environmental toxins and multiple myeloma
The International Myeloma Foundation (IMF)-supporting research and providing education, advocacy and support for myeloma patients, families, researchers and physicians-today said newly published data may provide a possible genetic link between environmental toxins and bone disease in multiple myeloma.
Mayo researchers find race has role in incidence, survival of rare brain tumor
The incidence of a rare and deadly tumor called primary central nervous system lymphoma (PCNSL) is two times higher in black Americans, ages 20 to 49, than in white Americans, according to a Mayo Clinic study published in the June issue of Journal of Neuro-Oncology.
Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
A new finding reveals that African-American patients with breast, ovarian, and prostate cancer tend to die earlier than patients of other races with these cancers, even when they receive identical medical treatment and when socioeconomic factors are controlled for.
Individuals who apply pesticides are found to have double the risk of blood disorder
A study involving 678 individuals who apply pesticides, culled from a U.S. Agricultural Health Study of over 50,000 farmers, recently found that exposure to certain pesticides doubles one's risk of developing an abnormal blood condition called MGUS (monoclonal gammopathy of undetermined significance) compared with individuals in the general population.
X-rays help predict permanent bone damage from bisphosphonates
Breast cancer patients, individuals at risk for osteoporosis and those undergoing certain types of bone cancer therapies often take drugs containing bisphosphonates.
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