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Researchers use statistical technique to find mix of biomarkers predicting mortality
September 21, 2006FINDINGS: Previous research has uncovered a range of biological markers that can predict disability, morbidity and mortality in older adults. In this study, the researchers analyzed 13 biomarkers representing neuroendocrine and vascular functions and immune and metabolic activity over 12 years in 1,189 high-functioning men and women aged 70-79 enrolled in the MacArthur Study of Successful Aging. The goals were to identify biomarker combinations (or high-risk pathways) associated with high levels of mortality in men and women, determine whether the biomarkers that most closely predicted mortality differed in men and women and develop prediction rules based on combinations of biomarker conditions. The researchers also sought to present "recursive partitioning," a statistical technique for identifying multiple and interacting predictors of an outcome, as a useful analytical tool for addressing research questions in the biomedical sciences. Using recursive partitioning, they found that combinations of neuroendocrine and immune markers frequently appeared in high-risk male pathways, while systolic blood pressure was present, in combination with other biomarkers, in high-risk female pathways.
IMPACT: Clinicians and researchers may be able to use recursive partitioning to identify the biological regulatory system's importance in predicting mortality in later life.
University of California - Los Angeles
Biomarkers Current Events and Biomarkers News RSSCancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene.
Saliva proteins change as women age
In a step toward using human saliva to tell whether those stiff joints, memory lapses, and other telltale signs of aging are normal or red flags for disease, scientists are describing how the protein content of women's saliva change with advancing age.
Elevated biomarkers lead to diminished quality of life in heart attack patients post-discharge
Many heart attack patients have high levels of cardiac biomarkers in the blood for several months after leaving the hospital, with more shortness of breath and chest pain, according to a Henry Ford Hospital study.
Largest-ever database for liver proteins may lead to treatments for hepatitis
Scientists at a group of 11 research centers in China are reporting for the first time assembly of the largest-ever collection of data about the proteins produced by genes in a single human organ.
Neuroimaging provides insights into new treatment options for Alzheimer's disease
With about 35 million people around the world suffering from Alzheimer's disease (AD) by the year 2010 and an expectation that these numbers will double every twenty years with approximately 115 million cases by 2050, pressure on healthcare systems worldwide will be intense.
Expectant moms, babies subjects of new Singapore study to prevent obesity and diabetes in adults
Three Singapore biomedical institutions have launched a major, long-term study of pregnant mothers and their fetuses as well as infant children to determine just how profoundly environmental factors early in life influence the onset of diseases such as obesity and diabetes in later years.
New finding suggests prostate biopsy is not always necessary
Researchers at Wake Forest University School of Medicine and the University of Wisconsin-Madison have discovered that some elevated prostate-specific antigen (PSA) levels in men may be caused by a hormone normally occurring in the body, and are not necessarily a predictor of the need for a prostate biopsy.
Scientists uncover new key to the puzzle of hormone therapy and breast cancer
The use of postmenopausal hormone therapy has decreased over time in the United States, which researchers suggest may play a key role in the declining rate of atypical ductal hyperplasia, a known risk factor for breast cancer.
New Notre Dame study provides insights into the molecular basis of tumor cell behavior
A new study by a team of researchers led by Crislyn D'Souza-Schorey, associate professor of biological sciences at the University of Notre Dame, sheds light on the molecular basis by which tumor cells modulate their surroundings to favor cancer progression.
Does green tea prevent cancer? Evidence continues to brew, but questions remain
Although scientists are reluctant to officially endorse green tea as a cancer prevention method, evidence continues to grow about its protective effects, including results of a new study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, which suggests some reduction in oral cancer.
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Biomarkers: The 10 Keys to Prolonging Vitality by William Evans (Author) Exciting new evidence from the USDA Human Nutrition Research Center on Aging at Tufts University has demonstrated that the body's decline is due not to the passing of years but to the combined effects of inactivity, poor nutrition, and illness -- much of which can be controlled. This breakthrough study shows that regardless of your age or present physical condition, the aging process can be slowed -- or even reversed! The authors have identified ten "biomarkers," the key physiological factors associated with prolonged youth and vitality: * lean body (muscle) mass |
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Biomarkers: 10 Determinants of Aging You Can Control by William Evans (Author), Irwin Rosenberg (Author) |
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Cancer Biomarkers by Ios Press Original research findings (and reviews solicited by the Editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. | |
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Biomarkers of Disease: An Evidence-Based Approach by Andrew K. Trull (Editor), Lawrence M. Demers (Editor), David W. Holt (Editor), Atholl Johnston (Editor), J. Michael Tredger (Editor), Christopher P. Price (Editor) This new publication takes a critical, evidence-based look at the efficacy of new diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. The use of biomarkers is growing, with a steady stream of new products being brought out by the pharmaceutical industry. However, in many cases the evidence which supports the use of these new methods as opposed to traditional biochemical tests has not yet been demonstrated, and it is intended that this volume will help clarify the strengths and weaknesses of using these biomarkers across a wide range of applications and in the various organs of the body. This approach will provide an invaluable overview of the diverse applications of biomarkers in medicine. |
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Biomarker Methods in Drug Discovery and Development (Methods in Pharmacology and Toxicology) by Feng Wang (Editor) Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research and development processes. As a volume in the Methods in Pharmacology and... |
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Biomarkers by S.V.S. Rana (Author), Sung-Eun Lee (Author) |
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Cardiac Biomarkers in Clinical Practice by James Januzzi (Author) Cardiac Biomarkers in Clinical Practice presents a case based approach to biomarkers in heart diseases including heart failure, ischemic heart disease, and outpatient. Divided into six sections, this book provides physicians and other health care providers with a clear understanding of the role of biomarkers in clinical cardiovascular medicine. |
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The Biomarker Guide: Volume 1, Biomarkers and Isotopes in the Environment and Human History (v. 1) by K. E. Peters (Author), C. C. Walters (Author), J. M. Moldowan (Author) Biomarkers are compounds found in crude oil with structures inherited from once-living organisms. They persist in oil spills, refinery products and archaeological artifacts, and can be used to identify the origin, geological age and environmental conditions prevalent during their formation and alteration. These two volumes will be an invaluable resource for geologists, petroleum geochemists, biogeochemists, environmental and forensic scientists, natural product chemists and archaeologists. The first of two volumes of The Biomarker Guide discusses the origins of biomarkers and introduces basic chemical principles relevant to their study. It goes on to discuss analytical techniques, and the applications of biomarkers in environmental and archaeological problems. |
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The Biomarker Guide: Volume 2, Biomarkers and Isotopes in Petroleum Systems and Earth History by K. E. Peters (Author), C. C. Walters (Author), J. M. Moldowan (Author) The second volume itemizes parameters used to genetically correlate petroleum and interpret thermal maturity and extent of biodegradation. It documents most known petroleum systems by geologic age throughout Earth history. |
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Cancer Biomarkers: Analytical Techniques for Discovery (Wiley - Interscience Series on Mass Spectrometry) by Mahmoud H. Hamdan (Author), Dominic M. Desiderio (Series Editor), Nico M. Nibbering (Series Editor) Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers. This book provides a comprehensive overview of current methodologies and technologies. It discusses biomarker discovery as a whole, rather than focusing on one specific marker or cancer. With information on both existing and potential biomarkers, Cancer Biomarkers: Analytical Techniques for Discovery: * Provides insights into the current technological platforms for biomarker discovery, including mass spectrometry combined with multidimensional chromatography,... |
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