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Calcineurin helps newborns breathe easy
September 22, 2006It is only very late in pregnancy that the lungs of the fetus complete their development so that the fetus will be able to breathe air when it is born. As a result, many premature babies suffer from the potentially life threatening respiratory distress syndrome. The proteins that control the final stages of lung development have not been identified.
Now, in a study appearing online on September 21, in advance of publication in the October print issue of the Journal of Clinical Investigation, Vrushank Davé and colleagues from the University of Cincinnati, show that in mice a protein known as calcineurin is essential for complete lung development.
Mice lacking calcineurin function in the epithelial cells of the lung were unable to breathe properly and died shortly after birth because their lungs failed to develop fully. These effects of calcineurin were mediated by a protein known as NFATc3, which was shown to activate the expression of many of the genes that need to be activated if the final stages of lung development are to proceed normally.
This study describes one pathway controlling the final stages of lung development in mice and might help researchers design strategies to treat respiratory distress syndrome in premature babies.
Journal of Clinical Investigation
This study describes one pathway controlling the final stages of lung development in mice and might help researchers design strategies to treat respiratory distress syndrome in premature babies.
Journal of Clinical Investigation
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More Calcineurin Current Events and Calcineurin News Articles
![Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A"2 myotoxins in vivo and in vitro [An article from: Comparative Biochemistry and Physiology, Part C]](http://ecx.images-amazon.com/images/I/51A51TBEEML._SL160_.jpg) |
Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A"2 myotoxins in vivo and in vitro [An article from: Comparative Biochemistry and Physiology, Part C] by E.H. Miyabara (Author), I.L. Baptista (Author), B. Lomonte (Author), Selistre (Author) This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Previous studies have shown that calcineurin activity plays a critical role in the myotoxic activity induced by crotoxin (CTX), a group II phospholipase A"2 (PLA"2) with neurotoxic and myotoxic actions. In order to address whether calcineurin is also important for the activity of non-neurotoxic group II PLA"2 myotoxins we have compared the effects of calcineurin inhibition on the myotoxic capacity of CTX and the non-neurotoxic PLA"2s, myotoxin II (Mt II) and myotoxin III (Mt III) from... |
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Panel assesses calcineurin inhibitors in children: FDA advisory panel.(Dermatologic Therapy): An article from: Skin & Allergy News by Sally Koch Kubetin (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on December 1, 2003. The length of the article is 728 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Panel assesses calcineurin inhibitors in children: FDA advisory panel.(Dermatologic Therapy) Author: Sally Koch Kubetin Publication: Skin & Allergy News (Magazine/Journal) Date: December 1, 2003 Publisher: International Medical News Group Volume: 34 Issue: 12 Page: 18(1) Distributed by Thomson... | |
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Calcineurin inhibitors may speed MF progression.(Cutaneous Oncology): An article from: Skin & Allergy News by Bruce Jancin (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on August 1, 2008. The length of the article is 503 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: Calcineurin inhibitors may speed MF progression.(Cutaneous Oncology) Author: Bruce Jancin Publication: Skin & Allergy News (Magazine/Journal) Date: August 1, 2008 Publisher: International Medical News Group Volume: 39 Issue: 8 Page: 25(1) Distributed by Gale, a part of Cengage... | |
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Calcineurin inhibitors and black boxes.(Guest Editorial): An article from: Pediatric News by Seth Orlow (Author) This digital document is an article from Pediatric News, published by Thomson Gale on March 1, 2006. The length of the article is 637 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Calcineurin inhibitors and black boxes.(Guest Editorial) Author: Seth Orlow Publication: Pediatric News (Magazine/Journal) Date: March 1, 2006 Publisher: Thomson Gale Volume: 40 Issue: 3 Page: 24(1) Distributed by Thomson... | |
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Calcineurin inhibitors offer advantages for eczema: tacrolimus, pimecrolimus.(Children's Health): An article from: Family Practice News by Kate Johnson (Author) This digital document is an article from Family Practice News, published by International Medical News Group on January 1, 2004. The length of the article is 862 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Calcineurin inhibitors offer advantages for eczema: tacrolimus, pimecrolimus.(Children's Health) Author: Kate Johnson Publication: Family Practice News (Magazine/Journal) Date: January 1, 2004 Publisher: International Medical News Group Volume: 34 Issue: 1 Page: 69(1) Distributed by Thomson... | |
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Calcineurin inhibitors may pose cancer risk in children: box warning needed.(Children's Health): An article from: Family Practice News by Sally Koch Kubetin (Author) This digital document is an article from Family Practice News, published by International Medical News Group on March 1, 2004. The length of the article is 894 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Calcineurin inhibitors may pose cancer risk in children: box warning needed.(Children's Health) Author: Sally Koch Kubetin Publication: Family Practice News (Magazine/Journal) Date: March 1, 2004 Publisher: International Medical News Group Volume: 34 Issue: 5 Page: 112(1) Distributed by Thomson... | |
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Choose calcineurin inhibitors over steroids for AD: use emollients continuously.(Dermatologic Therapy)(Atopic dermatitis): An article from: Skin & Allergy News by Kate Johnson (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on January 1, 2004. The length of the article is 958 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Choose calcineurin inhibitors over steroids for AD: use emollients continuously.(Dermatologic Therapy)(Atopic dermatitis) Author: Kate Johnson Publication: Skin & Allergy News (Magazine/Journal) Date: January 1, 2004 Publisher: International Medical News Group Volume: 35 Issue: 1 Page: 30(2) Distributed by Thomson... | |
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Hit atopic dermatitis on several fronts: cleansers, emollients, topical steroids, antihistamines, baths, and topical calcineurin inhibitors all can help.(Skin ... An article from: Family Practice News by Robert Finn (Author) This digital document is an article from Family Practice News, published by Thomson Gale on October 1, 2005. The length of the article is 749 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Hit atopic dermatitis on several fronts: cleansers, emollients, topical steroids, antihistamines, baths, and topical calcineurin inhibitors all can help.(Skin Disorders) Author: Robert Finn Publication: Family Practice News (Magazine/Journal) Date: October 1, 2005 Publisher: Thomson Gale Volume: 35 Issue: 19 Page: 42(1) Distributed by Thomson... | |
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Treating kids? Use topical calcineurin inhibitor with topical corticosteroid: for itching and burning.(Dermatologic Theraphy): An article from: Skin & Allergy News by Robert Finn (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on August 1, 2003. The length of the article is 2581 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Treating kids? Use topical calcineurin inhibitor with topical corticosteroid: for itching and burning.(Dermatologic Theraphy) Author: Robert Finn Publication: Skin & Allergy News (Magazine/Journal) Date: August 1, 2003 Publisher: International Medical News Group Volume: 34 Issue: 8 Page: 24(1) Distributed by Thomson... | |
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Caribbean meeting awash in dermatology pearls: calcineurin inhibitors, rosacea, biologics.(Dermatologic Therapy): An article from: Skin & Allergy News by Kerri Wachter (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on March 1, 2004. The length of the article is 907 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Caribbean meeting awash in dermatology pearls: calcineurin inhibitors, rosacea, biologics.(Dermatologic Therapy) Author: Kerri Wachter Publication: Skin & Allergy News (Magazine/Journal) Date: March 1, 2004 Publisher: International Medical News Group Volume: 35 Issue: 3 Page: 48(1) Distributed by Thomson... |
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