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Is Clostridium difficile-associated disease linked to use of common stomach medication?
September 26, 2006Clostridium difficile-associated disease (CDAD), often associated with antibiotic use, is recognized as a major avoidable cause of illness and death in hospital patients. CDAD also occurs in the community. Recently, controversy has surrounded a possible link of community-acquired CDAD to the use of proton pump inhibitors (PPIs), drugs commonly used to suppress acid production in the stomach.
Dial and colleagues, in a study using data from the United Kingdom's General Practice Research Database, identified patients in the community who were deemed to have CDAD because they had been prescribed the antibiotic vancomycin. (CDAD is the only indication for use of this antibiotic.) As in previous studies using other markers of CDAD, an increased risk of CDAD was associated with current use of PPIs. In a related commentary, Cunningham reviews the polarized debate around the pathogenesis of CDAD and notes that, although the findings of Dial and colleagues add weight to the evidence for an association between CDAD and PPI use, they do not settle the issue.
Canadian Medical Association Journal
Clostridium Difficile Current Events and Clostridium Difficile News RSSCommentary warns of unexpected consequences of proton pump inhibitor use in reflux disease
Despite being highly effective and beneficial for many patients, unexpected consequences are emerging in patients who are prescribed proton pump inhibitors (PPIs) for reflux diseases.
Deadly stomach infection rising in community settings, Mayo Clinic study finds
Mayo Clinic researchers have found that a sometimes deadly stomach bug, Clostridium difficile is on the rise in outpatient settings.
Eating right, not supplements, is best at keeping your good bacteria healthy, dietitian says
Healthy eating, not supplements, is the best way to keep the good bacteria in your gut healthy, says a dietitian and researcher.
Structure of antibiotic ramoplanin reveals promising mechanism
With the "last resort" antibiotic Vancomycin now plagued by the first signs of bacterial resistance, a scientific collaboration centered at Duke University has identified how a candidate successor antibiotic known as Ramoplanin A2 can kill pathogenic bacteria by interrupting how they form their cell membranes.
Antibiotics take toll on beneficial microbes in gut
It's common knowledge that a protective navy of bacteria normally floats in our intestinal tracts. Antibiotics at least temporarily disturb the normal balance.
Newly discovered reactions from an old drug may lead to new antibiotics
A mineral found at health food stores could be the key to developing a new line of antibiotics for bacteria that commonly cause diarrhea, tooth decay and, in some severe cases, death.
Doctors identify patients at high risk of C. difficile
Doctors have developed and validated a clinical prediction rule for recurrent Clostridium difficile (C. difficile) infection that was simple, reliable and accurate, and can be used to identify high-risk patients most likely to benefit from measures to prevent recurrence. Their findings appear in a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.
Hospital infection control strategies for antibiotic-resistant organisms
Hand-washing, a clean environment, appropriate infection barriers and early identification of patients at high risk of colonization with a transmissible microorganism remain the essential measures to prevent and control infection.
What makes C-Diff superbug deadly?
A major breakthrough about the potentially deadly superbug Clostridium difficile (C-diff) could lead to new ways to combat the bacterium, according to a study to be published March 1 in the journal Nature.
Monash scientists debug superbug
An international team of scientists, led by Monash University researchers, has uncovered the workings of a superbug that kills elderly hospital patients worldwide - a discovery that has the potential to save lives and health care systems billions of dollars each year.
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Clostridium Difficile Test (25 per Pack) by Marion Scientific A 20 minute latex agglutination test for C. difficile associated diarrhea, 5 minutes hands on time, requires no instrument, excellent screening tes for stool specimenst, sensitivity found to be from 92 to 95%, negative predictive value 97 to 98%, controls included, performs 25 patient tests. | |
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Giantmicrobes C. Diff Clostridium Difficile [Toy] by Giantmicrobes Giant Microbes are soft, cute, durable, well made, educational, and just a lot of fun too! Each 5-to-7 inch doll is accompanied by an image of the real microbe it represents, as well as information about the microbe. Give it up for C. Diff, hospital's notorious gangsta. |
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Meridian Immunocard Toxins A & B Kit, 50 Tests by Meridian Bioscience Features of the Meridian Immunocard Toxins A & B Kit: Membrane EIA single test for the qualitative detection of Clostridium difficile Toxins A and B in Stool Specimens. High sensitivity: both Toxin A and Toxin B are detected. Rapid detection: results in 15 minutes. No sample pre-treatment required. No reagent dilution required. Easy and single test procedure. Internal control of the procedure on each card. Kit Components: Test cards, specimen diluent, enzyme conjugate, positive control, wash reagent, substrate reagent, transfer pipettes. The product referenced on this detail page is sold be 50/bx. |
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Clostridium difficile (Current Topics in Microbiology and Immunology) by K. Aktories (Editor), T.D. Wilkins (Editor) Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in... |
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