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Heartburn drug may help to slow progression of chronic heart failure
September 26, 2006Additional research needed to verify results, including dosage and other safety issues
An over-the-counter medication used to treat heartburn and acid reflux also appears to help decrease the debilitating effects of chronic heart failure, preliminary research shows. But more testing must be done before the drug is recommended for use by heart failure patients, doctors say.
According to the research, the same type of chemical reaction that allows stomach acid to cause heartburn and create ulcers also appears to damage and weaken diseased hearts. Blocking this process with the drug famotidine (Pepcid) may help to slow the progression of chronic heart failure (CHF).
The research, conducted by the National Cardiovascular Center in Suitra, Japan, appears in the Oct. 3, 2006 edition of the Journal of the American College of Cardiology. Lead researcher Masafumi Kitakaze, MD, PhD, said although the initial results look promising, more research is needed.
"We performed the present prospective study with only 50 CHF patients," said Dr. Kitakaze, director of the Cardiovascular Division and vice president of the Research and Clinical Center at the National Cardiovascular Center. "Now we need to conduct a large-scale trial to confirm the present findings. The large-scale trial based on the results our present research may not help current heart failure patients because it takes time, but we hope it helps our children and grandchildren and others in the future."
Gary Francis, MD, did not participate in the research, but is a cardiologist and heart failure expert at Ohio's Cleveland Clinic. He, too, cautions that the benefits of famotidine for CHF patients remain unclear.
"At this point, we don't know whether it would help," said Dr. Francis, head of the Section of Clinical Cardiology at Cleveland Clinic. "In addition, there is an expense involved, and we're not certain what the dose should be or what the safety would be of larger doses if they were necessary.
"I certainly would not recommend that patients go out and start taking Pepcid three times a day or anything like that,\\\
American College of Cardiology
The research, conducted by the National Cardiovascular Center in Suitra, Japan, appears in the Oct. 3, 2006 edition of the Journal of the American College of Cardiology. Lead researcher Masafumi Kitakaze, MD, PhD, said although the initial results look promising, more research is needed.
"We performed the present prospective study with only 50 CHF patients," said Dr. Kitakaze, director of the Cardiovascular Division and vice president of the Research and Clinical Center at the National Cardiovascular Center. "Now we need to conduct a large-scale trial to confirm the present findings. The large-scale trial based on the results our present research may not help current heart failure patients because it takes time, but we hope it helps our children and grandchildren and others in the future."
Gary Francis, MD, did not participate in the research, but is a cardiologist and heart failure expert at Ohio's Cleveland Clinic. He, too, cautions that the benefits of famotidine for CHF patients remain unclear.
"At this point, we don't know whether it would help," said Dr. Francis, head of the Section of Clinical Cardiology at Cleveland Clinic. "In addition, there is an expense involved, and we're not certain what the dose should be or what the safety would be of larger doses if they were necessary.
"I certainly would not recommend that patients go out and start taking Pepcid three times a day or anything like that,\\\
American College of Cardiology
Chronic Heart Failure Current Events and Chronic Heart Failure News RSSInhibition of GRK2 is protective against acute cardiac stress injuries
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion.
Protein changes in heart strengthen link between Alzheimer's disease and chronic heart failure
A team of U.S., Canadian and Italian scientists led by researchers at Johns Hopkins report evidence from studies in animals and humans supporting a link between Alzheimer's disease and chronic heart failure, two of the 10 leading causes of death in the United States.
Childhood obesity: The increasing vascular drama
Obesity is one of the most important health problems in industrialized countries irrespective of socio-economic status, age, sex or ethnicity.
Atrial fibrillation linked to increased hospitalization in heart failure patients
Patients with atrial fibrillation, common in those with advanced chronic heart failure, have an increased risk of hospitalization due to heart failure.
Vanderbilt researchers pioneer an advanced sepsis detection and management system
When Jason Martin gives a talk about his research, he begins with the dramatic story of Mariana Bridi da Costa: The young Brazilian supermodel died from severe sepsis in January after amputation of both her hands and feet failed to stop its spread.
Exercise is safe, improves quality of life in patients with chronic heart failure
Regular exercise is safe for heart failure patients and may slightly lower their risk of death or hospitalization, according to results from the largest and most comprehensive clinical trial to examine the effects of exercise in chronic heart failure patients.
Healing heart attack victims, one cell at a time
By using the amount of carbon 14 in the atmosphere from above-ground nuclear testing in the 1950s and 1960, researchers have determined that cells in the human heart develop into adulthood.
Improved predictive value of biomarkers in HF makes earlier diagnosis and better management possible
With an ever ageing population and more people surviving a heart attack, heart failure is now the world's most prevalent chronic cardiovascular disease. Yet despite improvements in its diagnosis and management, heart failure remains a stubbornly incurable condition with a poor prognosis, largely amenable to little more than palliative therapy.
New target for heart failure therapy identified
A novel signaling pathway plays a significant role in the production of aldosterone, a hormone that promotes heart failure after a myocardial infarction, according to a study conducted by Thomas Jefferson University researchers.
While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
Based on a striking similarity between heart disease and Duchenne muscular dystrophy, researchers at Columbia University Medical Center have discovered that a new class of experimental drugs for heart failure may also help treat the fatal muscular disorder.
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