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Blood transfusion-transmitted infections: A global perspective
September 28, 2006Thanks to the many blood-safety interventions introduced since 1984, the overall risk for most transfusion-transmitted infections has become exceedingly small.
In the September 28 issue of the New England Journal of Medicine, Dr. Morris Blajchman, professor of Medicine at McMaster University, and medical director, Canadian Blood Services (Hamilton Centre), with co-author Dr. Eleftherios Vamvakas of Ottawa, puts into perspective the continuing risk of transfusion-transmitted infections as well as the possible safety interventions that might reduce that risk even further, particularly those due to emerging agents including variant Creutzfeldt-Jakob disease (vCJD) the human counterpart to mad cow disease.
With regard to the emerging pathogens, several newly-developed pathogen-reduction technologies have been shown to be effective in destroying most bacteria, viruses and parasites in donated blood, but ineffective against the pathogens that cause neurodegenerative diseases and those viruses that are present in exceedingly high concentrations in blood.
Newer technologies can also have a downside, notes Blajchman. They tend to reduce the effectiveness of the blood components, necessitating the transfusion of greater quantities and thus exposing patients to blood from more donors; thereby increasing the risk of infection transmission by transfusion.
"The possible additional safety interventions that might further reduce the risk of transfusion-transmitted infections will be debated extensively over the next few years," says Blajchman.
"Regardless of the outcomes of these debates it is clear that the risk of transmission is not static. As new agents continue to emerge, old ones change their properties and epidemiologic patterns, and new information and technology become available to change our understanding of that risk."
The commentary by Blajchman and Vamvakas was written in relation to an article in the same issue of the journal concerning the transfusion-transmission of HHV-8, a virus that has the potential to cause skin tumors (Kaposi's Sarcoma) in immunocompromised recipients.
McMaster University
Newer technologies can also have a downside, notes Blajchman. They tend to reduce the effectiveness of the blood components, necessitating the transfusion of greater quantities and thus exposing patients to blood from more donors; thereby increasing the risk of infection transmission by transfusion.
"The possible additional safety interventions that might further reduce the risk of transfusion-transmitted infections will be debated extensively over the next few years," says Blajchman.
"Regardless of the outcomes of these debates it is clear that the risk of transmission is not static. As new agents continue to emerge, old ones change their properties and epidemiologic patterns, and new information and technology become available to change our understanding of that risk."
The commentary by Blajchman and Vamvakas was written in relation to an article in the same issue of the journal concerning the transfusion-transmission of HHV-8, a virus that has the potential to cause skin tumors (Kaposi's Sarcoma) in immunocompromised recipients.
McMaster University
Blood Transfusion Current Events and Blood Transfusion News RSSDrugs to treat anemia in cancer patients linked to thromboembolism
Medications frequently given to cancer patients to reduce their risk of anemia are associated with an increased risk of deep vein thrombosis or pulmonary embolism, according to new research led by Dawn Hershman, M.D, M.S., co-director of the breast cancer program at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center.
Better blood screening process needed to prevent babesiosis transmission
Babesiosis is a potentially dangerous parasitic disease transmitted by ticks and is common in the Northeast and the upper Midwest. Babesia lives inside of red blood cells, meaning it can also be transmitted through a blood transfusion from an infected but otherwise asymptomatic blood donor.
Study dispels myth that new residents cause increase in medical errors in July
New research published in the September issue of the Journal of the American College of Surgeons challenges the widely held belief that more medical errors occur in teaching hospitals during the month of July due to the influx of new graduates from medical and nursing schools - also known as the "July Phenomenon."
Blood transfusion study: Less is more
A new study suggests that blood transfusions for hospitalized cardiac patients should be a last resort because they double the risk of infection and increase by four times the risk of death.
Hepatitis C infection: treatment options equally effective, likelihood of success known early on
Results of a long-awaited study of 3,070 American adults at Johns Hopkins and 118 other U.S. medical centers show that treatment with either of the two standard antiviral drug therapies is safe and offers the best way for people infected with hepatitis C to prevent liver scarring, organ failure and death.
Pre-chewed food could transmit HIV
Researchers have uncovered the first cases in which HIV almost certainly was transmitted from mothers or other caregivers to children through pre-chewed food.
Bleeding disorders going undiagnosed; new guidelines to help
Nearly one percent of the population suffers from bleeding disorders, yet many women don't know they have one because doctors aren't looking for the condition, according to researchers at Duke University Medical Center.
Blood transfusions and outcomes
An exhaustive review and analysis of the medical literature by a panel of experts at the International Consensus Conference on Transfusion and Outcomes (ICCTO) held this month in Phoenix concluded that there is little evidence to support a beneficial effect from the greatest number of transfusions currently being given to patients.
Screening to help prevent stroke in kids increases, but limited access a problem
The number of children with a certain blood disorder undergoing an ultrasound to help prevent stroke is up significantly in the past 10 years since the publication of a major study showing its benefits.
Study identifies characteristics of hospitals with low rates of surgical site infections
New research published in the December issue of the Journal of the American College of Surgeons (JACS) suggests that surgical procedures that are shorter in duration and the use of fewer blood transfusions characterize hospitals that have a lower incidence of surgical site infections (SSI).
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Transfusion by Cold Blood, Lydia Pense Cold Blood was originally signed in 1969 by Bill Graham to his own label and went on to record six albums before disbanding in the late 1970s. The band was revived in the late 1980s and the current lineup started to coalesce in the mid-‘90s under the direction of guitarist Steve Dunne, which culminated in a triumphant return to the Fillmore in 1998. In 2001, DIG Music released Vintage Blood: Live! 1973, a previously unreleased powerhouse collection of songs including their signature version of "You Got Me Hummin’," recorded in an intimate studio setting before a live audience.At the same time, former Cold Blood member Skip Mesquite, who had a number of songs he’d written and thought would be well- suited for Lydia, came in contact with DIG Music. Armed with these great new... |
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Saving Lives with Serum Albumin. Doctors today know the riddle of why an injured man, his wounds perfectly treated, may still not recover. He may be a victim of "shock", a dangerous trend toward failure of blood circulation. Unless this trend is promptly reversed, the effect is fatal. Now doctors have anew tool to fight shock - a tool newer than blood transfusions or plasma. This discovery, concentrated Serum Albumin, when used in shock cases, actually draws fluid from the body tissues into the circulation to make up the loss. This Human Serum Albumin is made from the blood you donate. Squibb Laboratories were among the first to produce Serum Albumin for our Armed Forces. ..... 1944 Squibb Ad, A5132. This Item is an original Magazine ad, taken from a vintage magazine of the year indicated. The ad is suitable for framing and displaying in your home or office. The scan of this item was taken through plastic film, however it is an accurate representation of the item. The nominal size is 10.5 inches by 14 inches. |
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Blood Banking and Transfusion Medicine: Basic Principles and Practice by Christopher D. Hillyer MD (Author), Leslie E. Silberstein MD (Author), Paul M. Ness MD (Author), Kenneth C. Anderson MD (Author), John D. Roback MD PhD (Author) Ever since the discovery of blood types early in the last century, transfusion medicine has evolved at a breakneck pace. This second edition of Blood Banking and Transfusion Medicine is exactly what you need to keep up. It combines scientific foundations with today's most practical approaches to the specialty. From blood collection and storage to testing and transfusing blood components, and finally cellular engineering, you'll find coverage here that's second to none. New advances in molecular genetics and the scientific mechanisms underlying the field are also covered, with an emphasis on the clinical implications for treatment. Whether you're new to the field or an old pro, this book belongs in your reference library. Integrates scientific foundations with clinical relevance to... |
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Blood Banking & Transfusion Medicine - 2nd Ed, 2007, Hillyer, Md; Et Al - Blood Bank Textbooks by Lab Products Blood Banking & Transfusion Medicine - 2nd Ed, 2007, Hillyer, MD; et al - Blood Bank Textbooks : Integrates scientific foundations with clinical relevance for clear understanding. Highlights advances in use of blood products and discusses current clinical controversies. Tableof Contents Part I. History 1. A Brief History of Blood Transfusion.Part II. Blood Banking A. Immunohematology i. Basic Principles 2. Principlesof the Immune System Central to Transfusion Medicine. 3. Principles of the Complement System Central to Transfusion Medicine. 4. Principles of Red Blood Cell Allo- and Autoantibody Formation and Function. ii. RedBlood Cell, Platelet and Leukocyte Antigens and Antibodies 5. Membrane Blood Group Antigens and Antibodies. 6. ABO and Related Antigens and Antibodies. 7. Rh, Kell,... |
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Blood Transfusion: Blood Being Given to a Patient from a Drip-Feed Bottle at St. James's Hospital Photography Giclee Poster Print, 24x18 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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No Blood ~ Medicine Meets the Challenge Since the AIDS and hepatitis scares of the 1980's, the public has become increasing aware of the very real risks associated with blood transfusions. When facing surgery, growing numbers of patients are demanding "No blood!" Among these are Jehovah's Witnesses, who refuse blood transfusions for religious reasons. In recent years, medical science has developed safe, effective nonblood alternatives in virtually every subspecialty of medicine. An improved standard of care for all patients has thus been made possible. This half-hour documentary, "No Blood -- Medicine Meets the Challenge", presents case histories along with interviews of health-care workers, legal experts, and leading medical authorities. Actual medical footage and computer animations help viewers understand what nonblood... |
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