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Edmonton Protocol clinical trial shows islet transplantation shows promising results
September 28, 2006Findings show promise for certain patients with severe Type 1 Diabetes
The Edmonton Protocol clinical trial, led by University of Alberta researcher Dr. James Shapiro, shows islet transplantation is a promising procedure for certain patients with severe Type 1 Diabetes. This research is published in the September 28, 2006 edition of The New England Journal of Medicine.
"This is the very first time a multicentre, international trial has been done in islet research," said Shapiro, a professor in the U of A Faculty of Medicine and Dentistry. "This really shows that islet transplantation can be tremendously successful in protecting against hypoglycemic unawareness."
Thirty-six adult volunteers at nine clinical trial sites in North America and Europe received up to three infusions of insulin-producing islets, which are non-functioning in people with Type 1 diabetes. The trial was designed to gauge how well the transplanted islets would function in regulating blood sugars. The results show that 44 per cent of the transplant recipients no longer needed insulin injections a year after their final treatment. An additional 28 per cent of them had partial islet function. Insulin independence did not persist indefinitely in most cases. However, individuals with functioning islets had improved control of their diabetes, even though they still needed to take insulin shots.
The first international, multicentre trial of the Edmonton Protocol is a standardized approach to islet transplantation. This approach demonstrates that this may be an appropriate therapy that can dramatically benefit certain patients with severe complications of Type 1 Diabetes Mellitus.
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University of Alberta
Thirty-six adult volunteers at nine clinical trial sites in North America and Europe received up to three infusions of insulin-producing islets, which are non-functioning in people with Type 1 diabetes. The trial was designed to gauge how well the transplanted islets would function in regulating blood sugars. The results show that 44 per cent of the transplant recipients no longer needed insulin injections a year after their final treatment. An additional 28 per cent of them had partial islet function. Insulin independence did not persist indefinitely in most cases. However, individuals with functioning islets had improved control of their diabetes, even though they still needed to take insulin shots.
The first international, multicentre trial of the Edmonton Protocol is a standardized approach to islet transplantation. This approach demonstrates that this may be an appropriate therapy that can dramatically benefit certain patients with severe complications of Type 1 Diabetes Mellitus.
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University of Alberta
Islet Transplantation Current Events and Islet Transplantation News RSSCell transplantation and diabetes: New sites, new devices
Early attempts at islet cell transplantation to treat diabetes date to the nineteenth century, decades before the discovery of insulin in the 1930s.
Pure insulin-producing cells produced in mouse
Singapore researchers have developed an unlimited number of pure insulin-producing cells from mouse embryonic stem cells (ESCs).
Researcher tricks immune system in diabetic mice
The body's immune system hates strangers. When its security patrol spots a foreign cell, it annihilates it.
Manipulating the immune system like a parasite
One day it may be possible to mimic the tactics used by parasites to trick the body into accepting transplanted tissues or organs.
The new source of islet cells
The shortage of islet cells limits the development of islet transplantation. One new approach was reported in the October 21 issue of the World Journal of Gastroenterology because of its great significance in enhancing the output of islet cells. This article will undoubtedly bring benefit to diabetic patients.
Circulating fats kill transplanted pancreas cells, study shows
Dietary restrictions or other strategies that limit fat formation might make pancreatic cell transplants more effective, UT Southwestern Medical Center researchers report.
Clinical trial shows islet transplantation is a promising procedure
The first international, multicenter trial of the Edmonton Protocol-a standardized approach to the transplantation of insulin-producing islets-demonstrates that this may be an appropriate therapy that can dramatically benefit certain patients with severe complications of Type 1 diabetes mellitus.
MRI can track survival of pancreatic islets after transplantation
Magnetic resonance imaging (MRI) with an approved contrast agent may provide a practical way of monitoring the survival of transplanted pancreatic islets.
Porcine islets offer promise for human diabetic patients
Islet cell xenotransplantation presents a promising near-term solution to the critically low islet cell supply for humans suffering from type 1 diabetes.
Severe Hypoglycemia is Rare After Islet Transplantation
Episodes of dangerously low blood glucose, or hypoglycemia, were greatly reduced in people who received an islet transplant for poorly controlled type 1 diabetes, according to an analysis of outcomes in 138 patients who had the procedure at 19 medical centers in the United States and Canada.
More Islet Transplantation Current Events and Islet Transplantation News Articles
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Islet Transplantation and Beta Cell Replacement Therapy by A.M. James Shapiro (Editor), James A.M. Shaw (Editor) Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and brings together leading multidisciplinary proponents critical to future success in the field. Edited by a surgeon and an endocrinologist at the forefront of the technology, this volume considers challenges associated with this procedure including lack of sufficient donor organs and the side effects of immunosuppressive therapy, as well as the potential benefits for current and future patients. |
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In vitro development of islets from human adult pancreatic tissues: An alternative source for clinical islet transplantation by Ru Gao (Author), Timo Otonkoski (Author) Transplantation of isolated islets from cadaver pancreas is a promising possibility for the optimal treatment of type 1 diabetes. However, such an approach is severely limited by the shortage of donor organs. And also the long-term function of human pancreatic islet grafts may depend on the neogenesis of beta cells from epithelial precursors within the grafted tissue. Islet neogenesis can be induced in adult mouse and human pancreatic ductal cell cultures. Using the in vitro model for human islet neogenesis, we confirm the capacity of endocrine differentiation from progenitors present in the adult human pancreas. Ductal cell differentiation into endocrine cells in transplanted islets may be an important factor in sustaining the long-term function of islet transplants. The... |
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Pancreas and Islet Transplantation by Nadey Hakim (Editor), Robert Stratta (Editor), Derek Gray (Editor) Diabetes Mellitus is the principle cause of kidney failure and blindness in adults and leads to more cases of amputation and impotence than any other disease. It is one of the most common chronic diseases in childhood. The aims of pancreas or islet transplantation are to improve the quality of life of patients with insulin dependent diabetes mellitus and to ameliorate secondary complications. This book provides a comprehensive and international review of the recent advances in pancreas and islet transplantation. It covers surgical techniques, issues surrounding organ preservation, immunosuppression and the control of other complications, all of which contribute to the potential for such transplantations to evolve as the treatment of choice for insulin dependent diabetes. The editors... |
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Islets: Biology, Immunology, and Clinical Transplantation by Fouad R. Kandeel (Editor) Islet Transplantation: Basic Biology, Immunology and Therapeutic Interventions in Type 1 Diabetes focuses primarily on state-of-the-art strategies for the improvement of islet transplantation methodologies. The book will be solidly built upon the foundation of two sections dedicated to elucidating the new knowledge of the normal biology of pancreatic islet cells and the latest understanding of the genetic, molecular, cellular, and environmental mechanisms involved in the pathophysiology of Type 1 diabetes. The book is written by internationally-renowned authorities in the field. This will ensure not only the validity and quality of this work, but that the most prominent breakthroughs will be accessed in the most up-to-date manner. | |
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Cellular Inter-Relationships in the Pancreas: Implications for Islet Transplantation (Medical Intelligence Unit) by Lawrence Rosenberg (Editor), William P. Duguid (Editor) | |
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Pancreatic Islet Cell Transplantation: 1892-1992 One Century of Transplantation for Diabetes (Medical Intelligence Unit) by Camillo, M.D. Ricordi (Editor) Intended for researchers and clinicians who work with cell transplantation, this text discusses the latest methods and gives an overall update of the major fields of islet transplantation. Included are reports of recent clinical trials on successful islet transplantation in humans. | |
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Islet cell transplant replicated in U.S., Europe. (Edmonton Protocol).(islet cell transplantation to treat type 1 diabetes): An article from: Family Practice News by Miriam E. Tucker (Author) This digital document is an article from Family Practice News, published by International Medical News Group on July 1, 2003. The length of the article is 817 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Islet cell transplant replicated in U.S., Europe. (Edmonton Protocol).(islet cell transplantation to treat type 1 diabetes) Author: Miriam E. Tucker Publication: Family Practice News (Magazine/Journal) Date: July 1, 2003 Publisher: International Medical News Group Volume: 33 Issue: 13 Page: 17(1) Distributed by Thomson... | |
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Success Continues for Islet Cell Transplantation in Type 1 Diabetes.(Brief Article): An article from: Family Practice News by Nancy Walsh (Author) This digital document is an article from Family Practice News, published by International Medical News Group on March 15, 2001. The length of the article is 883 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Success Continues for Islet Cell Transplantation in Type 1 Diabetes.(Brief Article) Author: Nancy Walsh Publication: Family Practice News (Magazine/Journal) Date: March 15, 2001 Publisher: International Medical News Group Volume: 31 Issue: 6 Page: 16 Article Type: Brief Article Distributed by Thomson... | |
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79% insulin independence at 1 year: Edmonton islet cell transplantation well tolerated but risky.(Clinical Rounds): An article from: Internal Medicine News by Robert Finn (Author) This digital document is an article from Internal Medicine News, published by International Medical News Group on April 1, 2004. The length of the article is 1830 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: 79% insulin independence at 1 year: Edmonton islet cell transplantation well tolerated but risky.(Clinical Rounds) Author: Robert Finn Publication: Internal Medicine News (Magazine/Journal) Date: April 1, 2004 Publisher: International Medical News Group Volume: 37 Issue: 7 Page: 27(1) Distributed by Thomson... | |
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Islet cell transplant's "perfect storm" results in new legislation, CMS reg, $75 million in research funding.(Pancreatic Islet Cell Transplantation Act ... Services): An article from: Transplant News by Jim Warren (Author) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on October 15, 2004. The length of the article is 1654 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Islet cell transplant's "perfect storm" results in new legislation, CMS reg, $75 million in research funding.(Pancreatic Islet Cell Transplantation Act of 2004)(Centers for Medicare and Medicaid Services) Author: Jim Warren Publication: Transplant News (Newsletter) Date: October 15, 2004 Publisher: Transplant Communications, Inc. Volume: 14 Issue:... |
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