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Women given liver transplants outlive male recipients by around 4 years
September 28, 2006Life expectancy of adult liver allograft recipients in the UK online first: Gut 2006
Female liver transplant recipients outlive men given the same procedure by an average of 4.5 years, suggests research published ahead of print in Gut.
And while younger people tend to live longest of all, they also stand to lose more years of their life compared with those who have not had liver transplants, the research shows.
The research team assessed the life expectancy and years of life lost of 2702 people who had received a liver transplant between 1985 and 2003, and who had survived more than six months afterwards..
The information was taken from the National Transplant Database, held by UK Transplant, and compared with that from healthy people matched for age and sex.
The analysis showed that, on average, after reaching the critical six month period, survival time for liver transplant recipients was 22 years compared with 29 years for the general population.
The life expectancy of male liver transplant recipients was 18 years compared with 26 years for women.
This compares with 27 years for men and 31 years for women in the general population, equating to twice as many years of life lost for male transplant recipients compared with their female counterparts.
Those aged between 17 and 34 had the highest life expectancy of 28 years after a liver transplant. But this compares with a life expectancy of 51 years for their peers in the general population.
Transplant recipients with primary liver disease fared significantly better than those undergoing the procedure because of hepatitis C infection, cirrhosis, or cancer.
The authors note that while one year survival rates have increased over time, death rates beyond this period have remained more or less the same.
They attribute this to the types of patients undergoing the procedure, who now include older, sicker patients, as well as the use of more "marginal" livers.
BMJ Specialty Journals
The research team assessed the life expectancy and years of life lost of 2702 people who had received a liver transplant between 1985 and 2003, and who had survived more than six months afterwards..
The information was taken from the National Transplant Database, held by UK Transplant, and compared with that from healthy people matched for age and sex.
The analysis showed that, on average, after reaching the critical six month period, survival time for liver transplant recipients was 22 years compared with 29 years for the general population.
The life expectancy of male liver transplant recipients was 18 years compared with 26 years for women.
This compares with 27 years for men and 31 years for women in the general population, equating to twice as many years of life lost for male transplant recipients compared with their female counterparts.
Those aged between 17 and 34 had the highest life expectancy of 28 years after a liver transplant. But this compares with a life expectancy of 51 years for their peers in the general population.
Transplant recipients with primary liver disease fared significantly better than those undergoing the procedure because of hepatitis C infection, cirrhosis, or cancer.
The authors note that while one year survival rates have increased over time, death rates beyond this period have remained more or less the same.
They attribute this to the types of patients undergoing the procedure, who now include older, sicker patients, as well as the use of more "marginal" livers.
BMJ Specialty Journals
Liver Transplant Current Events and Liver Transplant News RSSExtending treatment after liver transplant may benefit patients with hepatitis C recurrence
Extending hepatitis C treatment for liver transplant patients beyond current practice results in high rates of clearance of the hepatitis C virus from the blood, as well as a low rate of relapse, according to a Henry Ford Hospital study.
Lower tacrolimus doses is suitable for living donor liver transplantation with small-for-size graft
Several studies have shown that living donor liver transplant (LDLT) recipients required smaller doses of tacrolimus compared with deceased donor liver transplant (DDLT) patients, which indicated that liver regeneration could affect the metabolism of tacrolimus in LDLT.
First human gets new antibody aimed at hepatitis C virus
Building upon a series of successful preclinical studies, researchers at MassBiologics of the University of Massachusetts Medical School (UMMS) today announced the beginning of a Phase 1 clinical trial, testing the safety and activity of a human monoclonal antibody they developed that can neutralize the Hepatitis C virus (HCV).
Scientists link immune system's natural killer cells to infant liver disease
Scientists have linked an overactive response by one of the immune system's key weapons against infection - natural killer, or NK, cells - to the onset of biliary atresia in infants, a disease where blocked bile ducts can cause severe liver damage and death.
Mayo Clinic finds new pathology tests double sensitivity to detect bile duct and pancreatic cancers
Pancreatic cancer and bile duct cancer are difficult to diagnose and often fatal because they are discovered in the advanced stages of the disease.
Mayo Researchers Help Discover Genetic Cause for Primary Biliary Cirrhosis
Researchers have discovered a novel molecular path that predisposes patients to develop primary biliary cirrhosis, a disease that mainly affects women and slowly destroys their livers. Primary biliary cirrhosis has no known cause.
What is the function of lymph nodes?
If we imagine our immune system to be a police force for our bodies, then previous work has suggested that the Lymph nodes would be the best candidate structures within the body to act as police stations - the regions in which the immune response is organised.
Novel antibody prevents infection by hepatitis C virus
Taking aim at a leading cause of liver failure in the United States, a team of scientists at the Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV).
HIV positive and HIV negative patients have similar survival rates following liver transplant
HIV positive and HIV negative patients have comparable survival rates following liver transplant, according to new research presented today at EASL 2009, the Annual Meeting of the European Association for the Study of Liver in Copenhagen, Denmark.
Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease
A new study shows that an imaging technology developed by Mayo Clinic researchers can identify liver fibrosis with high accuracy and help eliminate the need for liver biopsies. Liver fibrosis is a common condition that can lead to incurable cirrhosis if not treated in time.
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