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Researchers announce results of study on genetic variation in Parkinson's disease
September 28, 2006Researchers at the National Institutes of Health (NIH) have completed one of the first large-scale studies of the role of common genetic variation in Parkinson's disease (PD). While the results fill in some missing pieces of the genetic puzzle, they are primarily of benefit as a starting point for more detailed studies. The information generated by the study is now publicly available in a database that will serve as a valuable research tool for the future.
The study was led by researchers at the National Institute of Aging (NIA) and National Institute of Neurological Disorders and Stroke (NINDS). The data were derived from blood samples of 267 people with PD and 270 neurologically normal individuals. These samples were made available by The NINDS Human Genetics Resource Center at the Coriell Institute (http://ccr.coriell.org/ninds), a publicly-funded bank for human cells, DNA samples, clinical data, and other information that aims to accelerate research on genetics of disorders of the nervous system. Results of the study appear in the September 27, 2006, early online publication of The Lancet Neurology.
"This is, to my knowledge, the first publicly available genotype data of this magnitude outside of the International HapMap effort, and certainly the first disease-linked dataset. I hope that this will prove to be a valuable resource for future genetics work in Parkinson's disease, both for our laboratory and for other researchers around the world," says Andrew Singleton, Ph.D., the NIA researcher who led the study. "The use of neurologically normal controls from the NINDS neurogenetics repository means that these data can be readily used as a control group in future large scale SNP studies performed in many other neurological diseases."
"The NINDS Human Genetics Resource Center has created a resource that allows broad sharing and access to phenotypic and genotypic data, as well as biological samples, with no restrictions. This approach to open, public sharing of genetic materials and data is unprecedented. It will allow scientific progress in the field of genetics to proceed in a much faster way, and in ways we can't even currently anticipate," says Katrina Gwinn-Hardy, M.D., the NINDS program contact for the Human Genetics Resource Center and an author on the paper.
NIH/National Institute of Neurological Disorders and Stroke
"The NINDS Human Genetics Resource Center has created a resource that allows broad sharing and access to phenotypic and genotypic data, as well as biological samples, with no restrictions. This approach to open, public sharing of genetic materials and data is unprecedented. It will allow scientific progress in the field of genetics to proceed in a much faster way, and in ways we can't even currently anticipate," says Katrina Gwinn-Hardy, M.D., the NINDS program contact for the Human Genetics Resource Center and an author on the paper.
NIH/National Institute of Neurological Disorders and Stroke
Genetic Variation Current Events and Genetic Variation News RSSEutrophication affects diversity of algae
Eutrophication of the seas may have an impact on genetic variation in algae, research at the University of Gothenburg shows.
Ironing out the genetic cause of hemoglobin problems
A gene with a significant effect on regulating hemoglobin in the body has been identified as part of a genome-wide association study, which looked at the link between genes and hemoglobin level in 16,000 people.
Jumping genes, gene loss and genome dark matter
In research published today by Nature, an international team describes the finest map of changes to the structure of human genomes and a resource they have developed for researchers worldwide to look at the role of these changes in human disease.
Genome-wide study of autism published in Nature
In one of the first studies of its kind, an international team of researchers has uncovered a single-letter change in the genetic code that is associated with autism.
African American lung cancer patients may have different response to new cancer-fighting drugs
Clinical research out of University Hospitals Case Medical Center has found that African Americans with a common form of lung cancer have a lower frequency of drug-sensitizing genetic mutations, which may impact response to new cancer-fighting drugs.
Discovery could improve hepatitis C treatment
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Scientists discover new genetic variation that contributes to diabetes
Scientists have identified a genetic variation in people with type 2 diabetes that affects how the body's muscle cells respond to the hormone insulin, in a new study published today in Nature Genetics. The researchers, from Imperial College London and other international institutions, say the findings highlight a new target for scientists developing treatments for diabetes.
Mice living in sandy hills quickly evolved lighter coloration
In a vivid illustration of natural selection at work, scientists at Harvard University have found that deer mice living in Nebraska's Sand Hills quickly evolved lighter coloration after glaciers deposited sand dunes atop what had been much darker soil. The work is described this week in the journal Science.
Gene variation is 'major genetic determinant of psoriasis'
A specific genetic region that has been increasingly identified as the strongest genetic link to psoriasis has an even more significant role in the chronic skin disease than has been suspected, University of Utah medical researchers show in a new study.
Genetic variation associated with poorer response, cardiovascular outcomes with use of clopidogrel
Patients with a certain genetic variation who received the antiplatelet drug clopidogrel had a decreased platelet response to treatment and among those who had percutaneous coronary intervention (procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries) had an increased risk of having a cardiovascular event in the following year than patients who did not have this variant, according to a study in the August 26 issue of JAMA.
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