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New gene linked to bipolar disorder
October 04, 2006A new gene linked to both depression and bipolar disorder has been identified by UCL (University College London) and Danish researchers.
The collaboration, led by Professor Hugh Gurling at UCL and Professor Ole Mors at the University of Aarhus, first looked at bipolar cases in families living in the UK and in Denmark, and then at large numbers of unrelated people with bipolar disorder. The results of the genetic searches, published in the October issue of the American Journal of Psychiatry, identified the gene - known as Slynar - which is found on chromosome 12.
The Slynar gene is normally found in the brain, but in bipolar disorder has an abnormal effect due to mutations in the gene. However, researchers do not yet know what the gene's normal function is or how these mutations might be contributing to the disorder.
Professor Hugh Gurling, UCL Department of Mental Health Sciences, says: "The next step is to determine the role of the Slynar gene in the brain and how abnormalities in this gene may cause bipolar disorder. Using techniques such as animal models will help us to fully understand the mechanisms behind this gene and explore how we might be able to intervene in these mechanisms, to help people with the disorder.
"We hope our discovery will eventually lead to new treatments for depression and bipolar disorder, including possible preventive strategies, for example with drugs or even through nutritional intervention.\\\
University College London
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UNC study pinpoints gene controlling number of brain cells
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Young Adults May Outgrow Bipolar Disorder
Bipolar disorder, or manic-depression, causes severe and unusual shifts in mood and energy, affecting a person's ability to perform everyday tasks. With symptoms often starting in early adulthood, bipolar disorder has been thought of traditionally as a lifelong disorder.
Mad Genius: Study Suggests Link Between Psychosis and Creativity
Vincent van Gogh cut off his ear. Sylvia Plath stuck her head in the oven. History teems with examples of great artists acting in very peculiar ways. Were these artists simply mad or brilliant? According to new research reported in Psychological Science, a journal of the Association for Psychological Science, maybe both.
Sleep patterns in children and teenagers could indicate risk for depression, researcher finds
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