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Technique to arrest urinary incontinence
October 04, 2006The University Hospital of Navarra is to carry out clinical trials for urinary incontinence using the intraurethral injection of myoblasts (adult stem cells obtained by means of a biopsy of the patient). The trials will be undertaken with 15 women with urinary incontinence. The project is to recruit the sufferers over a six-month period and to carry out the project jointly between the Cellular Therapy Area and the Department of Urology at the University Hospital of Navarra.
Amongst adult women, incontinence is largely due to the loss of muscular mass of the sphincter, recoverable by injecting this sphincter zone with the patient's own muscle cells (myoblasts) with the objective of regenerating this muscle, enhancing its contractility and reducing incontinence.
The knowledge of this technique worldwide is confined to less than 200 patients: half a dozen in Canada and about 180 in Austria. The initial idea is the same, although there are differences in how the cells are obtained and in their processing.
Biological scaffolding
The treatment of cystoceles (prolapses of the bladder) is currently undertaken using meshes that act to reinforce the original tissues. These are usually synthetic or of natural (biological) origin, but other, hybrid materials, are being worked with.
Thus, with this collaboration between the Department of Urology and the Cellular Therapy Area in adult stem cell therapy for the treatment of urinary incontinence and prolapses of the pelvic organs, there is another line of research: the use of biological meshes as a support or as "scaffolding" onto which cells are infiltrated so that the myofibroblasts might grow. It is intuitive to believe that the mesh becomes covered with the fibromuscular cells themselves, and that they penetrate the mesh. It is this that is really the reinforcement; the mesh is but a supportive scaffolding rather than an end in itself.
Cooperating in carrying out this project is the BARD company, which manufactures and markets biological meshes. A number of in vitro studies and experiments with animals will be undertaken in order to favour cell growth on the biological meshes and the effect of these with a number of agents. Then they will be implanted in model experimental animals to examine their capacity to integrate into the tissue and carry out the function of support.
Elhuyar Fundazioa
Biological scaffolding
The treatment of cystoceles (prolapses of the bladder) is currently undertaken using meshes that act to reinforce the original tissues. These are usually synthetic or of natural (biological) origin, but other, hybrid materials, are being worked with.
Thus, with this collaboration between the Department of Urology and the Cellular Therapy Area in adult stem cell therapy for the treatment of urinary incontinence and prolapses of the pelvic organs, there is another line of research: the use of biological meshes as a support or as "scaffolding" onto which cells are infiltrated so that the myofibroblasts might grow. It is intuitive to believe that the mesh becomes covered with the fibromuscular cells themselves, and that they penetrate the mesh. It is this that is really the reinforcement; the mesh is but a supportive scaffolding rather than an end in itself.
Cooperating in carrying out this project is the BARD company, which manufactures and markets biological meshes. A number of in vitro studies and experiments with animals will be undertaken in order to favour cell growth on the biological meshes and the effect of these with a number of agents. Then they will be implanted in model experimental animals to examine their capacity to integrate into the tissue and carry out the function of support.
Elhuyar Fundazioa
Urinary Incontinence Current Events and Urinary Incontinence News RSSPivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
New finding suggests prostate biopsy is not always necessary
Researchers at Wake Forest University School of Medicine and the University of Wisconsin-Madison have discovered that some elevated prostate-specific antigen (PSA) levels in men may be caused by a hormone normally occurring in the body, and are not necessarily a predictor of the need for a prostate biopsy.
Pelvic floor muscle exercises can help manage urinary incontinence in older women
Researchers at Rush University Medical Center have found that a program of pelvic floor muscle exercises, combined with pelvic health education, can be an effective way to manage urinary incontinence in elderly women.
Study finds no link between cognitive decline, socioeconomic status in elderly
New UCLA research suggests that for seniors age 70 and older, socioeconomic status does not play a major role in the brain's continued ability to function.
Uterus sparing surgery is a safe and effective treatment for pelvic organ prolapse
Researchers presented data at the 104th Annual Scientific Meeting of the American Urological Association (AUA) showing that uterus sparing surgery is an effective and safe treatment for women who want to preserve the integrity of vaginal function after pelvic organ prolapse.
Autologous muscle-derived cells may treat stress urinary incontinence
Researchers have confirmed that transplanting autologous muscle-derived cells (AMDC) into the bladder is safe at a wide range of doses and significantly improves symptoms and quality of life in patients with stress urinary incontinence.
M. D. Anderson study finds pre-surgical stress management improves mood, quality of life
Brief stress management sessions prior to and immediately after surgery may have both short- and long-term benefit for men undergoing a radical prostatectomy for early-stage prostate cancer.
Collagen injections can help some incontinence patients when surgery fails, researcher finds
Collagen injections can benefit women who still suffer from stress urinary incontinence (SUI) even after urethral or periurethral surgery, a UT Southwestern Medical Center researcher has found.
Weight Loss Reduces Incontinence for Women
Starting a weight-loss regimen significantly reduces urinary incontinence for women, according to researchers at the University of Alabama at Birmingham (UAB) and the University of California, San Francisco.
Bittersweet milestones
For many of the elderly, the golden years are anything but. Faced with health problems, financial issues and the death of a spouse or loved one, many adults 65 years and older suffer from depression. While research is emerging to help this group understand and treat the problem, another group - centenarians - has been left largely in the dark.
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