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Deakin University discovery could lead to new leukaemia treatments
November 07, 2006Deakin University scientists have identified a protein that could hold the key to new leukaemia treatments.
The protein-Stat5-was investigated at a laboratory at Deakin's Melbourne Campus at Burwood, as part of a multicentre international collaboration.
Leukaemia is a cancer caused by a proliferation of white blood cells. To understand and help prevent the disease, the Deakin researchers are looking for the responsible genes.
Head of the Deakin team, Associate Professor Alister Ward, said the discovery of how the protein acts provides a breakthrough in understanding the onset of leukaemia.
"We have found that Stat5 is responsible for making white blood cells overgrow in a particular disease setting that often precedes leukaemia," Associate Professor Ward explained.
"On top of this, we have also found that Stat5, when activated, is sufficient on its own to cause white blood cells to overgrow inside a whole organism.
"Together, these findings identify Stat5 as a major player in the process of leukaemia progression and is therefore a worthwhile target for intervention.\\\
Research Australia
Head of the Deakin team, Associate Professor Alister Ward, said the discovery of how the protein acts provides a breakthrough in understanding the onset of leukaemia.
"We have found that Stat5 is responsible for making white blood cells overgrow in a particular disease setting that often precedes leukaemia," Associate Professor Ward explained.
"On top of this, we have also found that Stat5, when activated, is sufficient on its own to cause white blood cells to overgrow inside a whole organism.
"Together, these findings identify Stat5 as a major player in the process of leukaemia progression and is therefore a worthwhile target for intervention.\\\
Research Australia
Leukaemia Current Events and Leukaemia News RSSParadoxical protein might prevent cancer
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell.
New cancer gene discovered
A new cancer gene has been discovered by a research group at the Sahlgrenska Academy. The gene causes an insidious form of glandular cancer usually in the head and neck and in women also in the breast. The discovery could lead to quicker and better diagnosis and more effective treatment.
Master gene that switches on disease-fighting cells identified by scientists
The master gene that causes blood stem cells to turn into disease-fighting 'Natural Killer' (NK) immune cells has been identified by scientists, in a study published in Nature Immunology today.
Human sperm created from embryonic stem cells
Human sperm have been created using embryonic stem cells for the first time in a scientific development which will lead researchers to a better understanding of the causes of infertility.
Cancer survivors at greater risk of birth complications; special monitoring needed
Survivors of childhood cancer run particular risks when pregnant and should be closely monitored.
If plants could talk, what would they say?
If plants could speak they will boast about being part of remedies such as the common aspirin to a leukaemia drug derived from the rosy periwinkle.
New genes involved in Acute Lymphoblastic Leukemia play fundamental role in prognosis of the disease
The inactivity or "silence" of certain genes plays a fundamental role in the prognosis of acute lymphoblastic leukemia (ALL) as well as in response to treatment, according to the results of research involving a team made up of specialists from the University Hospital of Navarra and the Centre for Applied Medical Research (CIMA) at the same University of Navarra, as well as the Reina Sofía Hospital in Córdoba, Andalusia.
New treatment hope for prostate cancer
Scientists at Melbourne's Burnet Institute have developed a potential new treatment for patients with prostate cancer. An article, which described the invention, has recently been published in the prestigious international journal The Journal of Clinical Investigation.
New study aims to reduce risk of childhood leukemia
A study led by Dr Marcus Cooke at the University of Leicester and funded by World Cancer Research Fund (WCRF) UK is looking at whether consuming caffeine during pregnancy might affect the unborn baby's risk of developing leukaemia in childhood.
New hope for multiple sclerosis sufferers
A drug which was developed in Cambridge and initially designed to treat a form of leukaemia has also proven effective against combating the debilitating neurological disease multiple sclerosis (MS).
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