Science Current Events | Science News | Brightsurf.com
 

Rapidly rising PSA before treatment is key indicator of cancer spread

November 09, 2006
Results of a new Fox Chase Cancer Center study show that men with a rapidly rising PSA level before treatment have a high probability of metastatic disease and should receive hormone therapy in addition to radiation. The findings were presented today at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia.

The rate of a rise in PSA level, known as PSA velocity (PSAV), can be used to determine when prostate cancer spread may have already occurred, even in men with clinically localized disease. PSA, or prostate specific antigen, is measured by a blood test and used to determine if prostate cancer is present.

"We've known that men with a rapidly rising PSA are at greater risk of prostate cancer-related death and this study suggests that undetected distant metastasis present prior to radiation therapy may be the cause," explained Mark K. Buyyounouski, M.D., M.S., an attending physician in the radiation oncology department at Fox Chase and lead author of the study. The study looked at data collected between 1989 and 1999 for 671 men with clinically localized prostate cancer who received 3-D conformal radiation therapy.

Buyyounouski and others demonstrated that when the PSAV was greater than 2 ng/ml per year, the PSA was likely to continue rising at the same rate despite radiation therapy to the prostate. What's more, this group of men was found to have a greater likelihood of distant spread of prostate cancer and a greater risk of dying of the disease. This relationship was not seen for men with a slower PSAV of less than 2 ng/ml.

"This study suggests that an initially high PSAV often represents previously undetected metastatic disease exists at the time of diagnosis," said Buyyounouski. "This disease has the opportunity to progress if radiation therapy to the prostate and surrounding tissue is the only treatment," said Buyyounouski. "Therefore, it is recommended that the PSAV be used in addition to other high risk factors to determine if androgen deprivation therapy should be part of the treatment."

Androgen deprivation therapy, or hormone therapy, has been shown to improve survival when used in conjunction with radiation therapy for men at high risk of undetected spread of prostate cancer.

Buyyounouski concluded that requiring a PSAV of less than 2 ng/ml will be important for selecting patients who are most likely to benefit from radiation therapy alone. This has important implications for studies designed to compare various radiation regimens such as hypofractionation.

Fox Chase Cancer Center


Related Radiation Therapy Current Events and Radiation Therapy News Articles


Every step you take: STING pathway key to tumor immunity
A recently discovered protein complex known as STING plays a crucial role in detecting the presence of tumor cells and promoting an aggressive anti-tumor response by the body's innate immune system, according to two separate studies published in the Nov. 20 issue of the journal Immunity.

Researchers pioneer new approach to treating HPV-related cervical cancer
A drug that is already well established as a treatment for infection of the retina in people with AIDS has been shown, for the first time, to sensitise cervical cancer to chemotherapy and radiotherapy without an increase in toxic side-effects.

Race, hospital, insurance status affect lung cancer treatment
African Americans, Hispanics and those who receive care at a community hospital are all significantly less likely than other patients to receive treatment for early stage non-small cell lung cancer, according to a report in the Journal of Thoracic Oncology.

Chemotherapy following radiation treatment slows disease progress
A chemotherapy regimen consisting of procarbazine, CCNU, and vincristine (PCV) administered following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas, a form of brain cancer, when compared to radiation therapy alone.

Killing cancer by protecting normal cells
Although radiation treatments have become much more refined in recent years, it remains a challenge to both sufficiently dose the tumor while sparing the surrounding tissue.

Conventional therapies are less efficient in prostate cancer patients carrying 'BRCA' mutations
Prostate cancer patients carrying inherited mutations in the BRCA genes respond less well to conventional treatment, including surgery and/or radiotherapy - and they also have a lower survival rate than those who are non-carriers of these genetic mutations.

Report card on complementary therapies for breast cancer
Over eighty percent of breast cancer patients in the United States use complementary therapies following a breast cancer diagnosis, but there has been little science-based guidance to inform clinicians and patients about their safety and effectiveness.

Proton therapy shown to be less costly than some alternative radiotherapy techniques
In terms of duration of treatment and cost, patients with early stage breast cancer may benefit from accelerated partial breast irradiation (APBI) with proton therapy versus whole breast irradiation (WBI), according to new research from The University of Texas MD Anderson Proton Therapy Center.

Experts recommend tumor removal as first-line treatment for acromegaly
The Endocrine Society today issued a Clinical Practice Guideline (CPG) for the diagnosis and treatment of acromegaly, a rare condition caused by excess growth hormone in the blood.

Clinical Practice Guidelines Address Multimodality Treatment for Esophageal Cancer
The Society of Thoracic Surgeons (STS) has released new clinical practice guidelines for treating cancer of the esophagus and gastroesophageal junction (area where the esophagus meets the stomach).
More Radiation Therapy Current Events and Radiation Therapy News Articles

Radiation Therapy (Quickstudy: Academic)

Radiation Therapy (Quickstudy: Academic)
by Inc. BarCharts (Author)


Radiation therapy (RT) is a dynamic but complex medical profession. Our comprehensive 3-panel (6-page) guide will make it all easy to understand, including the differences between RT and x-ray tech. All key aspects of RT—from basic radiophysics and radiobiology to radiotherapy safety and procedures—are covered in-depth, with up-to-date information that is enhanced by useful charts, tables and images of cutting-edge equipment. Each section features “The Tech Knows” summary of critical points, set off graphically for easy reference.

The Physics of Radiation Therapy

The Physics of Radiation Therapy
by Faiz M. Khan PhD (Author)


Dr. Khan's classic textbook on radiation oncology physics is now in its thoroughly revised and updated Fourth Edition. It provides the entire radiation therapy team—radiation oncologists, medical physicists, dosimetrists, and radiation therapists—with a thorough understanding of the physics and practical clinical applications of advanced radiation therapy technologies, including 3D-CRT, stereotactic radiotherapy, HDR, IMRT, IGRT, and proton beam therapy. These technologies are discussed along with the physical concepts underlying treatment planning, treatment delivery, and dosimetry. This Fourth Edition includes brand-new chapters on image-guided radiation therapy (IGRT) and proton beam therapy. Other chapters have been revised to incorporate the most recent developments in the field....

Khan's The Physics of Radiation Therapy

Khan's The Physics of Radiation Therapy
by Faiz M. Khan PhD (Author), John P. Gibbons PhD (Author)


Expand your understanding of the physics and practical clinical applications of advanced radiation therapy technologies with Khan's The Physics of Radiation Therapy, 5th edition, the book that set the standard in the field. This classic full-color text helps the entire radiation therapy team—radiation oncologists, medical physicists, dosimetrists, and radiation therapists—develop a thorough understanding of 3D conformal radiotherapy (3D-CRT), stereotactic radiosurgery (SRS), high dose-rate remote afterloaders (HDR), intensity modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), Volumetric Modulated Arc Therapy (VMAT), and proton beam therapy, as well as the physical concepts underlying treatment planning, treatment delivery, and dosimetry.

In preparing...

The Physics & Technology of Radiation Therapy

The Physics & Technology of Radiation Therapy
by Patrick N. McDermott (Author), Colin G. Orton (Author)


This book is the outgrowth of a course taught to residents in radiation oncology at Wayne State University, at the suggestion of residents who saw a need for a technically accurate text set at the correct mathematical level. It is intended to be a book to learn from, not a comprehensive compendium. It is written for members of the radiation therapy community such as radiation therapy technologists, dosimetrists, and radiation oncologists who may have taken college physics several years previously but still need to know the basic physics of radiation therapy. For graduate students in medical physics, it will serve as a review of the basics. The material is written to be relevant to clinical practice, without covering specifics in treatment planning, and also with a close eye on board...

Mosby's Radiation Therapy Study Guide and Exam Review (Print w/Access Code), 1e

Mosby's Radiation Therapy Study Guide and Exam Review (Print w/Access Code), 1e
by Leia Levy MAdEd(Masters in Adult Education) RT(T) (Author)


Reinforce your understanding of radiation therapy and prepare for the Registry exam! Mosby's Radiation Therapy Study Guide and Exam Review is both a study companion for Principles and Practice of Radiation Therapy, by Charles Washington and Dennis Leaver, and a superior review for the certification exam offered by the American Registry for Radiologic Technology (ARRT). An easy-to-read format simplifies study by presenting information in concise bullets and tables. Over 1,000 review questions are included in the book, with an additional 1,000 questions available online on the companion Evolve website. Written by radiation therapy expert Leia Levy, with contributions by other radiation therapy educators and clinicians, this study tool provides everything you need to prepare for the ARRT...

Principles and Practice of Radiation Therapy, 3e

Principles and Practice of Radiation Therapy, 3e
by Charles M. Washington MBA RT(T) FASRT (Author), Dennis T. Leaver MS RT(R)(T) FASRT (Author)


Learn everything you need to know about radiation therapy with the only comprehensive text written for radiation therapy students by radiation therapists. Principles and Practice of Radiation Therapy is designed to help you understand cancer management, improve clinical techniques for delivering doses of radiation, and apply complex concepts to treatment planning and delivery. This edition features enhanced learning tools and thoroughly updated content, including three new chapters to inform you of increasingly important technologies and practices. The up-to-date and authoritative coverage of this text make it a resource you'll want to consult throughout your radiation therapy courses and beyond.Complete coverage of radiation therapy provides all introductory content plus the full scope...

A Meditation to Help You With Radiation Therapy

A Meditation to Help You With Radiation Therapy
by Belleruth Naparstek (Author)


Guided imagery designed to help listeners see radiation treatment in a positive light; reduce adverse side effects, such as fatigue and nausea; help immune cells combat trouble spots; reduce anxiety; encourage feelings of hope, resiliency, safety and support. Followed by continous music. (Running Time: 32 minutes)

Radiation Therapy Planning

Radiation Therapy Planning
by Gunilla Bentel (Author)


A Doody's Core Title for 2011! All new expanded edition provides step-by-step guidelines on performing the technical aspects of radiation therapy. Important new coverage includes treatment preparation, 3-D treatment planning, dosimetry, new technologies, documentation, and quality assurance. In addition, you'll find added treatment planning guidelines by body region, and an expanded art program including many new 4-color illustrations.

Portal Design in Radiation Therapy, 2nd ed

Portal Design in Radiation Therapy, 2nd ed
by Byron G. Dasher (Author), Anne Marie Vann (Author), K Van Sickle and P Markwalter (Illustrator)


Portal Design in Radiation Therapy, 2nd Edition contains over 120 explicit diagrams illustrating the anatomy and lymphatics included in typical treatment portals. In addition, CT and MR anatomy are included, as well as tissue tolerance charts. Descriptions of surrounding anatomy, routes of spread, technical aspects of portal design and typical doses employed for each tumor site are provided.

Target Volume Delineation and Field Setup: A Practical Guide for Conformal and Intensity-Modulated Radiation Therapy

Target Volume Delineation and Field Setup: A Practical Guide for Conformal and Intensity-Modulated Radiation Therapy
by Nancy Y. Lee (Editor), Jiade J. Lu (Editor)


This handbook will enable radiation oncologists to appropriately and confidently select and delineate tumor volumes/fields for conformal radiation therapy, including intensity-modulated radiation therapy (IMRT), in patients with commonly encountered cancers. The orientation of this handbook  is entirely practical, in that the focus is on the illustration of clinical target volume (CTV) delineation for each major malignancy. Each chapter provides guidelines and concise knowledge on treatment planning and CTV selection, explains how the anatomy of lymphatic drainage shapes target volume selection, and presents detailed illustrations of delineations, slice by slice, on planning CT images. While the emphasis is on target volume delineation for three-dimensional conformal therapy and IMRT,...

© 2014 BrightSurf.com