Science Current Events | Science News | Brightsurf.com
 

Rapidly rising PSA before treatment is key indicator of cancer spread

November 09, 2006

Results of a new Fox Chase Cancer Center study show that men with a rapidly rising PSA level before treatment have a high probability of metastatic disease and should receive hormone therapy in addition to radiation. The findings were presented today at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia.

The rate of a rise in PSA level, known as PSA velocity (PSAV), can be used to determine when prostate cancer spread may have already occurred, even in men with clinically localized disease. PSA, or prostate specific antigen, is measured by a blood test and used to determine if prostate cancer is present.

"We've known that men with a rapidly rising PSA are at greater risk of prostate cancer-related death and this study suggests that undetected distant metastasis present prior to radiation therapy may be the cause," explained Mark K. Buyyounouski, M.D., M.S., an attending physician in the radiation oncology department at Fox Chase and lead author of the study. The study looked at data collected between 1989 and 1999 for 671 men with clinically localized prostate cancer who received 3-D conformal radiation therapy.

Buyyounouski and others demonstrated that when the PSAV was greater than 2 ng/ml per year, the PSA was likely to continue rising at the same rate despite radiation therapy to the prostate. What's more, this group of men was found to have a greater likelihood of distant spread of prostate cancer and a greater risk of dying of the disease. This relationship was not seen for men with a slower PSAV of less than 2 ng/ml.

"This study suggests that an initially high PSAV often represents previously undetected metastatic disease exists at the time of diagnosis," said Buyyounouski. "This disease has the opportunity to progress if radiation therapy to the prostate and surrounding tissue is the only treatment," said Buyyounouski. "Therefore, it is recommended that the PSAV be used in addition to other high risk factors to determine if androgen deprivation therapy should be part of the treatment."

Androgen deprivation therapy, or hormone therapy, has been shown to improve survival when used in conjunction with radiation therapy for men at high risk of undetected spread of prostate cancer.

Buyyounouski concluded that requiring a PSAV of less than 2 ng/ml will be important for selecting patients who are most likely to benefit from radiation therapy alone. This has important implications for studies designed to compare various radiation regimens such as hypofractionation.

Fox Chase Cancer Center


Related Radiation Therapy Current Events and Radiation Therapy News Articles


Study finds significant cognitive impairment in adult survivors of childhood brain tumors
Cancer survivors of childhood brain tumors show significant deficits in intelligence, educational achievement and employment, even decades after treatment, an unprecedented study at St. Jude Children's Research Hospital has found. The researchers said their findings will help guide efforts to prevent and alleviate such problems.

Scientists create imaging 'toolkit' to help identify new brain tumor drug targets
Stopping the growth of blood vessels in tumours is a key target for glioblastoma therapies, and imaging methods are essential for initial diagnosis and monitoring the effects of treatments.

Proton therapy controls common pediatric brain tumor with fewer long-term side effects
The use of proton radiotherapy to treat the most common malignant brain tumor in children is as effective as standard photon (x-ray) radiation therapy while causing fewer long-term side effects such as hearing loss and cognitive disorders, according to a study receiving online publication in Lancet Oncology.

Recommendation to omit radiation therapy after lumpectomy is not frequently implemented
Nearly two thirds of U.S. women age 70 or older with stage I breast cancer1 who undergo lumpectomy and are eligible to safely omit subsequent radiation therapy (RT) according to national cancer guidelines still receive this treatment, according to new study results.

1 in 7 colorectal cancer patients diagnosed before recommended screening age
Nearly 15 percent of patients diagnosed with colorectal cancer were younger than 50, the age at which screening recommendations begin.

Childhood cancer survivors face increased risk of metabolic syndrome
A new study of metabolic health risk factors in childhood cancer survivors showed increased risk for modifiable factors such as hypertension and overweight/obesity.

Many colorectal cancer patients are younger than the recommended screening age
In a recent analysis of US data, one in seven colorectal patients was younger than 50 years old, the recommended age to begin screening.

Radiation an important addition to treatment for pancreatic cancer surgery candidates
Radiation therapy was associated with a lower risk of cancer recurrence in pancreatic cancer surgery patients, making it, like chemotherapy, an important addition to treatment, Mayo Clinic research found.

Three hits to fight lung cancer
Although the most common type of lung cancer - non-small cell lung cancer (NSCLC) - has recently seen major treatment advances in some genetic subtypes, other subtypes continue to evade effective treatment.

Promising cancer therapy advanced by chemical explanation
Radiation therapy: A chilling word that creates images of burn-injuries where the cancer killing ray went through the skin.
More Radiation Therapy Current Events and Radiation Therapy News Articles

Radiation Therapy (Quickstudy: Academic)

Radiation Therapy (Quickstudy: Academic)
by Inc. BarCharts (Author)


Radiation therapy (RT) is a dynamic but complex medical profession. Our comprehensive 3-panel (6-page) guide will make it all easy to understand, including the differences between RT and x-ray tech. All key aspects of RT―from basic radiophysics and radiobiology to radiotherapy safety and procedures―are covered in-depth, with up-to-date information that is enhanced by useful charts, tables and images of cutting-edge equipment. Each section features “The Tech Knows” summary of critical points, set off graphically for easy reference.

Principles and Practice of Radiation Therapy, 4e

Principles and Practice of Radiation Therapy, 4e
by Charles M. Washington MBA RT(T) FASRT (Author), Dennis T. Leaver MS RT(R)(T) FASRT (Author)


The only radiation therapy text written by radiation therapists, Principles and Practice of Radiation Therapy, 4th Edition helps you understand cancer management and improve clinical techniques for delivering doses of radiation. A problem-based approach makes it easy to apply principles to treatment planning and delivery. New to this edition are updates on current equipment, procedures, and treatment planning. Written by radiation therapy experts Charles Washington and Dennis Leaver, this comprehensive text will be useful throughout your radiation therapy courses and beyond. Comprehensive coverage of radiation therapy includes a clear introduction and overview plus complete information on physics, simulation, and treatment planning.Spotlights and shaded boxes identify the most important...

Radiation Therapy Study Guide: A Radiation Therapist's Review

Radiation Therapy Study Guide: A Radiation Therapist's Review
by Amy Heath (Author)


This book is a comprehensive review and study aid for radiation therapists. Organized in a question-and-answer format, it present clinical features and principles of treatment. Topics include radiation therapy physics, radiobiology, treatment and simulation equipment, principles of patient care, clinical components of cancer care, and cancers of the brain, head and neck region, and respiratory, digestive, urinary, and male and female reproductive systems. It offers over 500 multiple-choice questions with detailed answers and rationales. Radiation Therapy Study Guide is a valuable resource for radiation therapists preparing for certification examinations as well as for practicing therapists in need of a review.

Step by Step Radiation Therapy: Treatment and Planning

Step by Step Radiation Therapy: Treatment and Planning
by Arun Kumar Rathi (Author)


Step by Step Radiation Therapy: Treatment and Planning is a practical guide to radiation therapy. The book covers basic principles, planning and delivery of radiation treatment in a step by step manner. Divided into 21 chapters, the book begins with the basics of radiation therapy planning. Subsequent chapters cover radiation therapy for a range of tumours, including breast, gastrointestinal, thoracic, central nervous system, genitourinary, thyroid, bone and soft tissue tumours. Other topics include the treatment of Hodgkin's disease, irradiation of blood products and spleen, palliative radiotherapy, re-irradiation, magna field radiotherapy, and radiotherapy of non-malignant diseases. The book concludes with information on emergency radiotherapy, management of side-effects, and...

Mosby's Radiation Therapy Study Guide and Exam Review (Print w/Access Code), 1e

Mosby's Radiation Therapy Study Guide and Exam Review (Print w/Access Code), 1e
by Leia Levy MAdEd(Masters in Adult Education) RT(T) (Author)


Reinforce your understanding of radiation therapy and prepare for the Registry exam! Mosby's Radiation Therapy Study Guide and Exam Review is both a study companion for Principles and Practice of Radiation Therapy, by Charles Washington and Dennis Leaver, and a superior review for the certification exam offered by the American Registry for Radiologic Technology (ARRT). An easy-to-read format simplifies study by presenting information in concise bullets and tables. Over 1,000 review questions are included in the book, with an additional 1,000 questions available online on the companion Evolve website. Written by radiation therapy expert Leia Levy, with contributions by other radiation therapy educators and clinicians, this study tool provides everything you need to prepare for the ARRT...

Principles and Practice of Radiation Therapy, 3e

Principles and Practice of Radiation Therapy, 3e
by Charles M. Washington MBA RT(T) FASRT (Author), Dennis T. Leaver MS RT(R)(T) FASRT (Author)


Learn everything you need to know about radiation therapy with the only comprehensive text written for radiation therapy students by radiation therapists. Principles and Practice of Radiation Therapy is designed to help you understand cancer management, improve clinical techniques for delivering doses of radiation, and apply complex concepts to treatment planning and delivery. This edition features enhanced learning tools and thoroughly updated content, including three new chapters to inform you of increasingly important technologies and practices. The up-to-date and authoritative coverage of this text make it a resource you’ll want to consult throughout your radiation therapy courses and beyond.Complete coverage of radiation therapy provides all introductory content plus the full scope...

The Physics & Technology of Radiation Therapy

The Physics & Technology of Radiation Therapy
by Patrick N. McDermott (Author), Colin G. Orton (Author)


This book is the outgrowth of a course taught to residents in radiation oncology at Wayne State University, at the suggestion of residents who saw a need for a technically accurate text set at the correct mathematical level. It is intended to be a book to learn from, not a comprehensive compendium. It is written for members of the radiation therapy community such as radiation therapy technologists, dosimetrists, and radiation oncologists who may have taken college physics several years previously but still need to know the basic physics of radiation therapy. For graduate students in medical physics, it will serve as a review of the basics. The material is written to be relevant to clinical practice, without covering specifics in treatment planning, and also with a close eye on board...

Khan's The Physics of Radiation Therapy

Khan's The Physics of Radiation Therapy
by Faiz M. Khan PhD (Author), John P. Gibbons PhD (Author)


Expand your understanding of the physics and practical clinical applications of advanced radiation therapy technologies with Khan's The Physics of Radiation Therapy, 5th edition, the book that set the standard in the field. This classic full-color text helps the entire radiation therapy team—radiation oncologists, medical physicists, dosimetrists, and radiation therapists—develop a thorough understanding of 3D conformal radiotherapy (3D-CRT), stereotactic radiosurgery (SRS), high dose-rate remote afterloaders (HDR), intensity modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), Volumetric Modulated Arc Therapy (VMAT), and proton beam therapy, as well as the physical concepts underlying treatment planning, treatment delivery, and dosimetry.

In preparing...

Radiation Therapy Planning

Radiation Therapy Planning
by Gunilla Bentel (Author)


A Doody's Core Title for 2011! All new expanded edition provides step-by-step guidelines on performing the technical aspects of radiation therapy. Important new coverage includes treatment preparation, 3-D treatment planning, dosimetry, new technologies, documentation, and quality assurance. In addition, you'll find added treatment planning guidelines by body region, and an expanded art program including many new 4-color illustrations.

Radiation Therapy Essentials: Board Preparation Tool

Radiation Therapy Essentials: Board Preparation Tool
by Anne Marie Vann (Author)


Radiation Therapy Essentials is intended as a refresher for those preparing for board certification or recertification in the field of radiation oncology. Outline format brings key points to the forefront. Examples and diagrams are provided for easy recognition and clarification of the topic. Over 200 practice questions and answers are included.

© 2016 BrightSurf.com