How to grow muscle cells in a dishNovember 10, 2006
In a study that appears online on November 9, in advance of publication in the December print issue of the Journal of Clinical Investigation, Catherine Verfaille and colleagues at the University of Minnesota Medical School, Minneapolis, show that SMCs can be generated from multipotent adult progenitor cells (MAPCs) isolated from the bone marrow of rats, mice, pigs, and humans. These cells only generated SMCs if exposed to the soluble factor TGF-beta or TGF-beta and another soluble factor PDGFB. SMC development from MAPCs occurred along the normal pathway of SMC development and the cells that were generated had all the functions of normal SMCs. This study therefore identifies a model system for studying the effects of potential therapeutics on SMC development and SMCs. It also describes a potential source of SMCs for engineering tissues.
Journal of Clinical Investigation
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