Science Current Events | Science News | Brightsurf.com
 

How to grow muscle cells in a dish

November 10, 2006

Smooth muscle cells (SMCs) are a crucial cellular component of many parts of the body, including blood vessels, the intestines, and the lungs. SMCs in the blood vessels are involved in several causes of heart disease and understanding how SMCs are generated is important for designing therapies for such diseases. It is also knowledge that could be used to engineer tissues in the laboratory, for example new blood vessels for use in bypass surgery.

In a study that appears online on November 9, in advance of publication in the December print issue of the Journal of Clinical Investigation, Catherine Verfaille and colleagues at the University of Minnesota Medical School, Minneapolis, show that SMCs can be generated from multipotent adult progenitor cells (MAPCs) isolated from the bone marrow of rats, mice, pigs, and humans. These cells only generated SMCs if exposed to the soluble factor TGF-beta or TGF-beta and another soluble factor PDGFB. SMC development from MAPCs occurred along the normal pathway of SMC development and the cells that were generated had all the functions of normal SMCs. This study therefore identifies a model system for studying the effects of potential therapeutics on SMC development and SMCs. It also describes a potential source of SMCs for engineering tissues.

Journal of Clinical Investigation


Related Muscle Cell Current Events and Muscle Cell News Articles


Mouse study links heart regeneration to telomere length
Researchers at the Spanish National Center for Cardiovascular Research have discovered that the ends of heart muscle cell chromosomes rapidly erode after birth, limiting the cells' ability to proliferate and replace damaged heart tissue.

Public Release: 28-Mar-2016 'Transient contractions' in urinary bladder may lead to therapeutic interventions for bladder dysfunction
Researchers at the University of Vermont College of Medicine have made a discovery that helps explain how we know when to empty our bladders and may lead to new therapeutic interventions for bladder dysfunction.

Pioneering discovery leads to potential preventive treatment for sudden cardiac death
More than 15 years ago, David Warshaw, Ph.D., and coworkers discovered the precise malfunction of a specific protein in the heart that leads to hypertrophic cardiomyopathy, a common culprit in cases of sudden death in young athletes.

Manipulating cell signaling for better muscle function in muscular dystrophy
Every heart beat and step in our daily lives is dependent on the integrity of muscles and the proteins that keep them strong and free of injury as they contract and relax.

Gene therapy treats all muscles in the body in muscular dystrophy dogs
Muscular dystrophy, which affects approximately 250,000 people in the U.S., occurs when damaged muscle tissue is replaced with fibrous, fatty or bony tissue and loses function.

Alternative strategy for gene replacement shows promise in duchenne muscular dystrophy
A gene therapy approach to treating the progressive muscle wasting disorder Duchenne muscular dystrophy (DMD) that does not replace the mutated DMD gene but instead delivers the gene for ITGA7, a protein in skeletal muscle, led to reduced symptoms and significantly extended life span in a mouse model of severe DMD.

New methodology tracks changes in DNA methylation in real time at single-cell resolution
Whitehead Institute researchers have developed a methodology to monitor changes in DNA methylation over time in individual cells.

Hypertension in professional football players likely results from trauma on the field
The regular physical trauma that appears to put professional football players at risk for degenerative brain disease may also increase their risk for hypertension and cardiovascular disease, researchers say.

Skeletal muscle atrophy in congestive heart failure
It is a paradox: Patients with advanced congestive heart failure lose skeletal muscle mass, but their heart muscles become enlarged to provide the body with an adequate supply of blood and thus with oxygen.

Muscle fibers grown in the lab offer new model for studying muscular dystrophy
Skeletal muscle is one of the most abundant tissue types in the human body, but has proven difficult to produce in large quantities in the lab.
More Muscle Cell Current Events and Muscle Cell News Articles

PMR and GCA disease: A Day Journal of PMR and Temporal Arteritis

PMR and GCA disease: A Day Journal of PMR and Temporal Arteritis


When illness attacked my body in 2013, I had no idea what was happening. It came on slow, steady, then fast, and debilitating. I felt death within my body and didn't know how to tell a physician or anyone else. They thought it was in my mind, fabricated. I began to wonder the same, but somehow knew I was sick, really sick. A kind of illness I'd never felt before. I thought at times I was going crazy and blind.
Doctor said, it's probably depression, but I didn't think so. I had been depressed before and it didn't feel like this. I feel I'm losing my mind. When I look for the right word to speak it doesn't come easily, sometimes not at all. I'd rather not speak than be upset trying to find the word, any word to explain myself. Is it Alzheimer's? Is it Dementia? What's the difference?...

Airways Smooth Muscle: Structure, Innervation and Neurotransmission (Respiratory Pharmacology and Pharmacotherapy)

Airways Smooth Muscle: Structure, Innervation and Neurotransmission (Respiratory Pharmacology and Pharmacotherapy)
by David Raeburn (Editor), Mark A. Giembycz (Editor)


Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma­ tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be­ tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on...

Anatomy, Histology, & Cell Biology: PreTest Self-Assessment & Review, Fourth Edition

Anatomy, Histology, & Cell Biology: PreTest Self-Assessment & Review, Fourth Edition
by Robert Klein (Author), George Enders (Author)


PreTest is the closest you can get to seeing the USMLE Step 1 before you take it500 USMLE-type questions and answers! "This edition of PreTest is full of extremely high-yield information in a presentation that is logical and effective. The questions and explanations are invaluable, and the HY tables and figures make it easy to review important material efficiently." -- Gustaf Van Acker III, Fourth Year MD/PhD Candidate, University of Kansas School of Medicine "This book was an excellent refresher for anyone looking to review information for either their final course exam or for the USMLE Step 1." -- Ben Chidester, Second Year Medical Student, Eastern Virginia Medical School Great for course review and the USMLE Step 1, Anatomy, Histology, & Cell Biology: PreTest asks the right...

The Body Fat Solution: Five Principles for Burning Fat, Building Lean Muscle, Ending Emotional Eating, and Maintaining Your Perfect Weight

The Body Fat Solution: Five Principles for Burning Fat, Building Lean Muscle, Ending Emotional Eating, and Maintaining Your Perfect Weight
by Tom Venuto (Author)


The national bestseller with the ultimate program to lose body fat and build muscle-and keep the weight off for good

By now, we all know that we gain fat when we take in more calories than we burn. But we're not always rational creatures when it comes to food and exercise. Tom Venuto provides a sound plan that will help us put the brakes on overeating by pinpointing the mental roadblocks and emotional eating patterns that are preventing us from losing weight for good. Guiding readers to dig deeper, The Body Fat Solution explores:

?Why it is so difficult to balance calorie output with input

?What prevents people from eating appropriately and exercising more

?The emotional and psychological factors that sabotage success

The Body Fat Solution...

Muscle Contraction (Outline Studies in Biology)

Muscle Contraction (Outline Studies in Biology)
by Clive R. Bagshaw (Author)


Movement in living organisms is achieved by many different mechanisms of which muscle contraction is one of the most studied and best understood. Nevertheless, the precise details of muscle action at the molecular level are still being evaluated. This book provides a concise account of our understanding to date.

Bodybuilding in 20 minutes: effects, new muscle cells: Gain 20 pounds of muscle or lose 20 pounds of fat easily. Part 2.

Bodybuilding in 20 minutes: effects, new muscle cells: Gain 20 pounds of muscle or lose 20 pounds of fat easily. Part 2.


Hereafter, I demonstrate the benefits of the innovative and effective 20 minute bodybuilding training.
The keys of muscle growth and fat loss are defined clearly in this tome.

This book is solely for information and educational purposes and does not constitute any type of professional advice, nor it substitutes to your physician advice.

Stem Cells For Dummies

Stem Cells For Dummies
by Lawrence S.B. Goldstein (Author), Meg Schneider (Author)


The first authoritative yet accessible guide to this controversial topic Stem Cell Research For Dummies offers a balanced, plain-English look at this politically charged topic, cutting away the hype and presenting the facts clearly for you, free from debate. It explains what stem cells are and what they do, the legalities of harvesting them and using them in research, the latest research findings from the U.S. and abroad, and the prospects for medical stem cell therapies in the short and long term. Explains the differences between adult stem cells and embryonic/umbilical cord stem cells Provides both sides of the political debate and the pros and cons of each side's opinions Includes medical success stories using stem cell therapy and its promise for the future Comprehensive and...

The Physiology of Excitable Cells

The Physiology of Excitable Cells
by David J. Aidley (Author)


The fourth edition of this highly successful text has been extensively revised and restructured to take account of the many recent advances in the field. The classic observations of recent years can now be interpreted with the powerful new techniques of molecular biology. Consequently, there is much new material throughout the book, including many new illustrations and extensive references to recent work. The text's essential philosophy remains the same, however: it clearly explains fundamental concepts, and examines key experiments in detail. This thorough and clearly written textbook will be valuable for students of physiology, neuroscience, cell biology and biophysics.

Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells
by F.J. Alvarez-Leefmans (Editor), John M. Russell (Editor)


This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther­ modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and...

Watch Me Grow: Fun Ways to Learn About Cells, Bones, Muscles, and Joints

Watch Me Grow: Fun Ways to Learn About Cells, Bones, Muscles, and Joints
by Michelle O'Brien-Palmer (Author)


This science activity book for children 5 to 9 explores the musculoskeletal system-bones, muscles, and joints and other connective tissues-and the amazing cells they are made of, where all growth really takes place. Sixty hands-on games, experiments, and activities show what the cells of an orange look like, how our spines are constructed, how our knees and elbows work, what calcium does for our bones, how tendons and ligaments fasten bones and muscles together, and much more. A “growth portfolio” allows young scientists to track their growth, and silly songs and lively illustrations help them remember new words and concepts. All the activities have been tested in homes and classrooms to be sure they are safe, effective, and fun.


© 2017 BrightSurf.com