Science Current Events | Science News | Brightsurf.com
 

With BYU partner, FSU's Magnet Lab researchers deciphering flu virus

November 10, 2006
TALLAHASSEE, Fla. - As the Northern Hemisphere braces for another flu season, researchers at Florida State University's National High Magnetic Field Laboratory are making strides toward better understanding the mechanics of the virus that causes it - a virus that kills between one-quarter and one-half million people each year.

Tim Cross, director of the lab's Nuclear Magnetic Resonance (NMR) program, and collaborators from Brigham Young University are trying to understand the minute parts of the highly virulent Influenza Type A virus. To do that, they are using all of the magnet lab's NMR resources, including its 15-ton, 900-megahertz magnet, to produce a detailed picture of the virus's skin.

"Using the magnet helps us build a blueprint for a virus's mechanics of survival," said Cross, who also is a professor of chemistry and biochemistry at FSU. "The more detailed the blueprint, the better our chances of developing drugs capable of destroying it."

The only magnet of its kind in the world, the "900" is critical to the project's process. Otherwise, an image this complicated would be impossible to obtain.

Cross and David Busath, a biophysicist at Brigham Young University, recently discovered key components of the protein holes, or "channels," in the influenza viral skin. These components lead to unique chemical reactions that are thought to be important clues for understanding how the channels regulate whether the virus can distribute its genes into host cells and reproduce or not. The researchers' findings were published recently in the Proceedings of the National Academy of Sciences.

"This is a viral structure we haven't seen before," Busath said. "And yet, through these tiny little doors, acids must come in and DNA must go out if the virus is to survive. The idea is to block the door to prevent the normal function required for the virus to replicate."

Once researchers understand how these channels are selective for acid, they can use that knowledge to fashion novel drugs capable of more effectively killing the virus.

Florida State University


Related Flu Virus Current Events and Flu Virus News Articles


In-depth analysis of bat influenza viruses concludes they pose low risk to humans
Zoonosis-transmission of infections from other vertebrates to humans-causes regular and sometimes serious disease outbreaks.

Study: Viral infection in nose can trigger middle ear infection
Middle ear infections, which affect more than 85 percent of children under the age of 3, can be triggered by a viral infection in the nose rather than solely by a bacterial infection, according to researchers at Wake Forest Baptist Medical Center.

Avian influenza virus isolated in harbor seals poses a threat to humans
A study led by St. Jude Children's Research Hospital scientists found the avian influenza A H3N8 virus that killed harbor seals along the New England coast can spread through respiratory droplets and poses a threat to humans.

Club cells are 'bad guys' during flu infection
A specialized subset of lung cells can shake flu infection, yet they remain stamped with an inflammatory gene signature that wreaks havoc in the lung, according to a study published in The Journal of Experimental Medicine.

Potential new flu drugs target immune response, not virus
The seriousness of disease often results from the strength of immune response, rather than with the virus, itself.

Sea Otters Can Get the Flu, Too
Northern sea otters living off the coast of Washington state were infected with the same H1N1 flu virus that caused the world-wide pandemic in 2009.

Birds of all feathers and global flu diversity
A group of international scientists have completed the first global inventory of flu strains in birds by reviewing more than 50 published studies and genetic data, providing new insight into the drivers of viral diversity and the emergence of disease that can ultimately impact human health and livelihoods.

Researchers discover immune signature that predicts poor outcome in influenza patients
St. Jude Children's Research Hospital scientists have identified a signature immune response that might help doctors identify which newly diagnosed influenza patients are most likely to develop severe symptoms and suffer poor outcomes.

Stanford researchers take a step toward developing a 'universal' flu vaccine
Every year the approach of flu season sets off a medical guessing game with life or death consequences. There are many different strains of flu and they vary from year to year. So each season authorities must make an educated guess and tell manufacturers which variants of the flu they should produce vaccines against.

1950s pandemic influenza virus remains a health threat, particularly to those under 50
St. Jude Children's Research Hospital scientists have evidence that descendants of the H2N2 avian influenza A virus that killed millions worldwide in the 1950s still pose a threat to human health, particularly to those under 50.
More Flu Virus Current Events and Flu Virus News Articles

Flu: The Story Of The Great Influenza Pandemic of 1918 and the Search for the Virus that Caused It

Flu: The Story Of The Great Influenza Pandemic of 1918 and the Search for the Virus that Caused It
by Gina Kolata (Author)


A national bestseller, the fast-paced and gripping account of the Great Flu Epidemic of 1918 from acclaimed science journalist Gina Kolata, now featuring a new epilogue about avian flu.

When we think of plagues, we think of AIDS, Ebola, anthrax spores, and, of course, the Black Death. But in 1918 the Great Flu Epidemic killed an estimated 40 million people virtually overnight. If such a plague returned today, taking a comparable percentage of the U.S. population with it, 1.5 million Americans would die.

In Flu, Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. From Alaska to Norway, from the streets of Hong Kong to the corridors of the White House, Kolata tracks the race to...

Bird Flu: A Virus of Our Own Hatching

Bird Flu: A Virus of Our Own Hatching
by Michael Greger (Author)


From age-old scourges such as smallpox and tuberculosis to emerging threats like AIDS and SARS, our interactions with animals have always played a pivotal role as a source of human disease. Bird flu is the latest such menace coming home to roost. Leading public health authorities now predict as inevitable a pandemic of influenza, triggered by bird flu and expected to lead to millions of deaths around the globe. The influenza virus has existed for millions of years as an innocuous intestinal virus of wild ducks. What turned a harmless waterborne duck virus into a killer? In Bird Flu, Dr. Michael Greger traces the human role in the evolution of this virus, whose humble beginnings belie its transformation into a killer mutant strain with the potential to become as ferocious as...

The Flu - A Guide To The Influenza A Virus (Pandemic, Sickness, h1n1, swine flu, bird flu, Illness, Virus, Cold, Cough, Fever, Epidemic, Vaccine, Antiviral, Health)

The Flu - A Guide To The Influenza A Virus (Pandemic, Sickness, h1n1, swine flu, bird flu, Illness, Virus, Cold, Cough, Fever, Epidemic, Vaccine, Antiviral, Health)


Discover How The Influenza A Virus Works
Today only, get this Kindle book for just $2.99. Read on your PC, Mac, smart phone, tablet or Kindle device.

You’re about to learn a brief history of the influenza virus, how it functions, the challenge to control this virus, the signs and symptoms, the current treatments, and what kind of prophylactic (preventative) measures you can take to stay healthy during an epidemic or pandemic.

In the United States, respiratory diseases represent more than half of the acute infections during a given year. Influenza, commonly known as the flu, is one of the most threatening infections in the respiratory system

Here Is A Preview Of What You'll Learn...
The History of Influenza Pandemics How The Virus...

The Eye of the Virus

The Eye of the Virus


(Revised Feb 2014): A new strain of avian influenza makes its debut in a small village in Vietnam. Like a ricocheting bullet, the virus affects the lives people worldwide until it is stopped by a team of epidemiologists. Myriam is a British PR executive on holiday with her husband when he becomes the first person infected in Hong Kong. Her life is completely changed by the experience, in ways she never predicted. Brian is an American scientist who invents a new antiviral medication, but fakes test data so that it can be released early. Jie is an epidemiologist at the Chinese CDC in Beijing, who will solve the puzzle of the new virus. As the unknown virus quickly spreads its way across the globe, entire societies are affected and changed by the outbreak, leaving the reader with the...

The Flu

The Flu
by Jacqueline Druga (Author)


Throughout history there have been several thousand different strains of influenza. Each year hundreds are active. Chances are, this year, you will catch one of those strains. You will cough, sneeze, and your body will ache. Without a second thought, you’ll take a double dose of green liquid, go to bed, and swear you’ll feel better in the morning. Not this time. In 1918 forty million people succumbed to a particular strain of swine flu. It appeared out of nowhere, and just as quickly as it surfaced, the Spanish Flu vanished. Gone for good. Or so we thought. Though mankind has anticipated its resurfacing for some time, mankind is ill prepared. Mutated and with a vengeance, the Spanish Flu returns. In a world blackened with plague, a glimmer of light exists in the small town of Lodi,...

Herbal Antivirals: Natural Remedies for Emerging & Resistant Viral Infections

Herbal Antivirals: Natural Remedies for Emerging & Resistant Viral Infections
by Stephen Harrod Buhner (Author)


Take control of your health! Emerging viruses are becoming more virile and aggressive, and traditional medications are becoming less effective against them. In this companion to the best-selling Herbal Antibiotics, Stephen Harrod Buhner offers in-depth instructions on how to prepare and use herbal formulations to strengthen the immune system and treat viral infections such as SARS, influenza, and encephalitis.

The Flu 2: Healing

The Flu 2: Healing
by Permuted Press


Get Book One of "THE FLU" here: http://amzn.to/1cvJE6T OR get both books in one duology, "FLU-OLOGY: here: http://amzn.to/187r1DE

A deadly flu pandemic has decimated humanity. Now, the remaining twenty percent of the population must rise from the ashes to rebuild.

The losses are great and no one is immune to the residual heartache that lingers in the air of the barren cities.

Life goes on.

Mick Owens, struggling to come to terms with his own grief, takes his surviving young sons away from their hometown and the memories it holds. But their short trip to clear their minds turns ugly when the world outside of Lodi Ohio isn’t what they expected and they become separated.

In a world without communication and power, a land...

Viruses, Plagues, and History: Past, Present and Future

Viruses, Plagues, and History: Past, Present and Future
by Michael B. A. Oldstone (Author)


The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses.
Oldstone begins with smallpox, polio, and measles. Nearly 300 million people were killed by smallpox in this century alone and the author presents a vivid account of the long campaign to eradicate this lethal killer. Oldstone then describes the fascinating viruses that have captured headlines in more recent years: Ebola, Hantavirus, mad cow disease (a frightening illness made worse by government mishandling and secrecy), and, of course, AIDS. And he tells us of the many scientists...

Ebola: How to prepare for Ebola now virus is in the US

Ebola: How to prepare for Ebola now virus is in the US


UPDATED IN VIEW OF CURRENT POSITION OCT 2014

Ebola has been dominating the world news in recent weeks. The Ebola outbreak in West Africa has infected hundreds of people and has claimed many lives. The concern is that the Ebola virus will transfer around the world very quickly. The reason that this is a real danger is that Ebola Symptoms can take as long as 21 days to show themselves, in this time the virus can be spread around the world.

However, unlike flu the virus, Ebola is not airborne. This gives us a good chance of being able to fight it and stop the Ebola outbreak from spreading.

This book covers the viral symptoms of the Ebola virus - it tells you what to look out for. Like many infectious diseases, Ebola transfers quickly where there is...

The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and Government Neglect

The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and Government Neglect
by Debbie Bookchin (Author), Jim Schumacher (Author)


Jonas Salk's polio vaccine is regarded as a veritbale medical miracle, for it largely eradicated one of the most feared diseases of the 20th century. But the story of the vaccine has a dark side, one that has never been fully told before. Between 1954 and 1963, close to 98 million Americans received polio vaccinations contaminated with a carcinogenic monkey virus, now known as SV40. The government downplayed the incident, and it was generally accepted that although oncogenic to lab animals, SV40 was harmless to humans. But now SV40 is showing up in human cancers, and prominent researchers are demanding a serious public health response to this forgotten polio vaccine contaminant. A gripping medical detective story, The Virus and the Vaccine raises major questions about vaccine...

© 2014 BrightSurf.com