 |
|
Two drugs may stabilize plaques in atherosclerosis
November 13, 2006WINSTON-SALEM, N.C. - Two drugs that a Wake Forest University School of Medicine research team has been investigating for lupus for several years may stabilize atherosclerotic plaque in the walls of arteries and help avert heart attacks and strokes.
Nilamadhab Mishra, M.D., and colleagues reported at the American College of Rheumatology meeting in Washington that the two drugs - TSA (trichostatin A) and SAHA (suberoylanilide hydroxamic acid ) - decreased cholesterol deposits in the walls of arteries.
The two drugs are part of a class of drugs called histone deacetylase inhibitors, or HDIs, which work by multiple mechanisms, one of which is anti-inflammatory: they decreased inflammatory proteins produced by macrophages, a type of white blood cell. These inflammatory proteins can make the atherosclerotic plaque unstable. Mishra said. The macrophages were taken from normal mice and the experiments were done in a laboratory setting.
After the macrophages were treated with either TSA or SAHA, the researchers also measured dramatic decreases in LDL and total cholesterol in the macrophages.
And the drugs prevented macrophages from turning into foam cells inside arterial walls, which is a key component of the buildup of plaque that leads to a narrowing of the arteries and increases the risk of heart attacks and strokes.
With the growing understanding that atherosclerosis, also known as hardening of the arteries, is in part an inflammatory disease, Mishra noted that doctors might be able to take advantage of the anti-inflammatory effects of TSA and SAHA.
Mishra, a rheumatologist, is looking for new ways to treat atherosclerosis because, he said, "Premature accelerated atherosclerosis is one of the leading causes of death and disability in lupus."
He added, "There is great enthusiasm to develop drugs that can stabilize atherosclerotic plaque and reduce acute coronary events."
SAHA already is being tested as an anticancer drug, and TSA is an antifungal antibiotic also being tested against cancer.
The research is part of a larger project, supported by a $1,793,750 grant from the National Institutes of Health, to further develop the HDI class of drugs for the treatment and prevention of atherosclerosis, Mishra said.
"Despite the success of lipid-lowering drugs for the prevention of coronary artery disease and myocardial infarction (heart attacks), atherosclerosis remains the most common cause of disease-related death in the Western world and in developing countries," he said.
Wake Forest University Baptist Medical Center
After the macrophages were treated with either TSA or SAHA, the researchers also measured dramatic decreases in LDL and total cholesterol in the macrophages.
And the drugs prevented macrophages from turning into foam cells inside arterial walls, which is a key component of the buildup of plaque that leads to a narrowing of the arteries and increases the risk of heart attacks and strokes.
With the growing understanding that atherosclerosis, also known as hardening of the arteries, is in part an inflammatory disease, Mishra noted that doctors might be able to take advantage of the anti-inflammatory effects of TSA and SAHA.
Mishra, a rheumatologist, is looking for new ways to treat atherosclerosis because, he said, "Premature accelerated atherosclerosis is one of the leading causes of death and disability in lupus."
He added, "There is great enthusiasm to develop drugs that can stabilize atherosclerotic plaque and reduce acute coronary events."
SAHA already is being tested as an anticancer drug, and TSA is an antifungal antibiotic also being tested against cancer.
The research is part of a larger project, supported by a $1,793,750 grant from the National Institutes of Health, to further develop the HDI class of drugs for the treatment and prevention of atherosclerosis, Mishra said.
"Despite the success of lipid-lowering drugs for the prevention of coronary artery disease and myocardial infarction (heart attacks), atherosclerosis remains the most common cause of disease-related death in the Western world and in developing countries," he said.
Wake Forest University Baptist Medical Center
Atherosclerosis Current Events and Atherosclerosis News RSSVitamin B niacin offers no extra benefit to statin therapy in seniors already diagnosed with CAD
The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing plaque buildup in seniors who already have coronary artery disease, a new vascular imaging study from Johns Hopkins experts shows.
Early end to key study on benefits of niacin, a B vitamin, in keeping arteries open was premature
Heart experts at Johns Hopkins are calling premature the early halt of a study by researchers at Walter Reed Army Medical Center and Washington Hospital Center on the benefits of combining extended-release niacin, a B vitamin, with cholesterol-lowering statin medications to prevent blood vessel narrowing.
Can charcoal fight heart disease in kidney patients?
Charcoal may provide a new approach to managing the high rate of heart disease in patients with advanced kidney disease, according to preliminary research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Experts unveil new CVD guidelines and position papers
Several new guidelines and position papers offering the most up to date information to ensure that clinicians practice evidence-based medicine were released at the Canadian Cardiovascular Congress 2009 this week.
Canadian scientists link fat hormone to death from potentially deadly blood infection
A new Canadian study has found that lower-than-normal levels of a naturally-occurring fat hormone may increase the risk of death from sepsis-an overwhelming infection of the blood which claims thousands of lives each year.
Healthy neighborhoods may be associated with lower diabetes risk
Individuals living in neighborhoods conducive to physical activity and providing access to healthy foods may have a lower risk of developing type 2 diabetes in a five-year period, according to a report in the October 12 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Liver cells grown from patients' skin cells
Scientists at The Medical College of Wisconsin in Milwaukee have successfully produced liver cells from patients' skin cells opening the possibility of treating a wide range of diseases that affect liver function.
National report shines light on lupus 50-year treatment drought
Today, The Lewin Group, a national health care consulting firm, issued recommendations on ways to overcome the barriers that have obstructed lupus drug development resulting in no new drug approval for this disease in more than 50 years - since the Eisenhower Administration.
Calcium scans may be effective screening tool for heart disease
A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death.
Despite size, NFL players not more likely to develop heart disease, even after retirement
Former professional football players with large bodies don't appear to have the same risk factors for heart disease as their non-athletic counterparts, UT Southwestern Medical Center researchers have found in studying a group of National Football League (NFL) alumni.
More Atherosclerosis Current Events and Atherosclerosis News Articles
 |
Dyslipidemia and Atherosclerosis Essentials 2009 by Christie M. Ballantyne (Author), James H. O'Keefe (Author), Antonio M. Gotto (Author) The World's Leading Experts Provide all the 'Essentials' Needed to Manage Patients in the Office, on the Ward, and in the Intensive Care Unit! Written by key opinion leaders in the field of cardiology, Dyslipidemia Essentials integrates the latest clinical guidelines and trials into a practical step-by-step guide to the management of dyslipidemia. Important clinical trials, common management pitfalls, and other cardiovascular risk reduction measures are also emphasized. Topics include: Step-by-step guide to intensive LDL lowering; NCEP ATP III and AHA/ACC guideline Updates; Treatment of low HDL cholesterol and elevated triglyceride; 73 dyslipidemia trials and 17 drug summaries |
 |
Anatomical Artery Cholesterol Atherosclerosis - Progressively Clogged by GPI Cholesterol: 4-Stage cross section of an artery demonstrating arteriosclerosis in which the narrowing of the artery is due to a build up of fatty tissue (cholesterol) and plaque. 4-Stages: normal artery, fatty streak, fibrous plaque, and blockage. The stages cause a decrease in blood flow, which can lead to a blood clot or thrombus. All stages rotate on hinge pin. Suitable for Cardio-Vascular, Cardiology and Internal Medicine, general anatomical study, training for surgical dissection, or for patient education or demonstration of procedures. Quantity discounts available. Made of a durable, plastic material accurately designed and colored to represent the major structures and, in certain instances, lesions or other abnormalities as described above. We also have available the unique... |
|
Journal of Atherosclerosis and Thrombosis by Japan Publications Trading Co | |
 |
Unclog Your Arteries : How I Beat Atherosclerosis by Gene McDougall (Author) Heart attack or bypass surgery? - or even if not- if you are overweight, have high blood pressure, high blood sugar, diabetes, high cholesterol, heart disease, or a family history of any, read this and then keep it for reference. |
 |
Nature Made Selenium Supplement Tablets, 200 mcg, 100-Count Bottles (Pack of 3) by Nature Made An antioxidant that complements Vitamin E to help protect cells from free radicals thought to be responsible for cellular damage. |
 |
Transeophageal Echo Aorta with Heavy Atherosclerosis Photographic Poster Print, 40x30 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
 |
Biochemistry of Atherosclerosis (Advances in Biochemistry in Health and Disease) by Sukhinder C. Kaur (Editor) At its present rate of growth, atherosclerosis will be the major cause of death from disease by the year 2020. Atherosclerosis is an extremely complex, biochemical, multifactorial process. This book will cover many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. We will cover all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. This book will explore the role of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. Finally, how the use of genetic studies can help sort out the immense complexities that mediate these aspects of atherogenesis will be discussed. |
 |
Women, Stroke and the Red Dress: Cerebrovascular Disease in Women In most age groups, more men than women will have a stroke in a given year. However, more than half of total stroke deaths occur in women. At all ages, more women than men die of stroke. This talk will discuss the reasons for these disparities throughout a women's lifetime. |
 |
Taurine 500mg With B6 - 100 - Tablet by Country Life TAURINE 500 mg w/B-6 Free Form Amino Acid Supplement with B-6 Hypoallergenic/Kosher A non-essential amino acid that aids in fat metabolism. B-6 aids in the utilization of Taurine.** Directions: Adults take one (1) to two (2) tablets daily, preferably between meals. Other Ingredients: Cellulose, stearic acid, magnesium stearate, silica, cellulose & glycerin coating. No: Yeast, corn, wheat, soy, gluten, milk, salt, sugar, starch, preservatives or artificial color. ... |
 |
Glucose-Balance - Sale! Dr. Kang's formula for use in treating diabetes mellitus and prevents damage of heart;liver;kidney and atherosclerosis from diabetes. Limited time offer. by Trilight,Inc. From the Western scientific perspective, diabetes mellitus is an inherited endocrine disorder characterized by a variable degree of carbohydrate intolerance and specific vascular lesions (i.e., thickening of the capillary basement membrane.) The endocrine aspect of this disease is the lack of sufficient pancreatic insulin to take up nutrients from the blood, in particular, glucose. The short term danger would then be a sort of tissue starvation leading to rapid fat metabolism leading to ketoacidosis and ultimately to metabolic acidosis, shock and death. The long term dangers involve vascular lesions beginning in the lower extremities and fundus of the eye leading to tissue death, loss of sight and limb amputation. In the short term, immediate symptoms include thirst, hunger and frequent... |
| © 2009 BrightSurf.com |