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Newly identified strains of Chlamydia trachomatis could produce new diseases
November 16, 2006A new study led by a scientist at Children's Hospital Oakland Research Institute (CHORI) is the first to conclude that Chlamydia trachomatis is evolving at a rate faster than scientists first thought or imagined. Chlamydia trachomatis is a bacterium that is the leading cause of sexually transmitted diseases and the second leading cause of blindness worldwide. Scientists believe the bacterium is evolving through a process called recombination where genes from one or more strains combine to create new strains and - theoretically - new diseases.
The study is featured in the November issue of Genome Research and was led by Dr. Deborah Dean MD, MPH, senior scientist at Children's Hospital Oakland Research Institute (CHORI). Her research suggests that since Chlamydia trachomatis evolves through recombination where one or more strains combine, the traditional method of studying a single gene to track the transmission of the bacterium is wrong. "What we found is an organism that not only evolves rapidly, but in ways that we thought were rare. We also discovered that this organism can customize its attack," said Dr. Dean. "Consequently, the constant flux of the bacterium could serve as a gateway for new emerging diseases, but more research needs to be conducted to understand if and how this is happening."
Previously, the organism was identified using a single gene, ompA, and the protein encoded by that gene, MOMP. In this study, the clinical strains, which are samples of Chlamydia trachomatis currently responsible for human disease today, were compared to standard reference strains that have been laboratory adapted over the last few decades. By studying multiple strains, the researchers discovered that the strains that were identified as the same strain were actually different.
The next step will be to study clinical strains in comparison with laboratory reference strains to decipher exactly how different strains cause disease and whether new diseases are emerging as a result of the emergence of new strains. "Large-scale comparative genomics will be necessary to understand the precise mechanisms underlying Chlamydia trachomatis recombination and how other species of chamydiae may evolve and transfer from animals to humans."
Children's Hospital & Research Center at Oakland
Chlamydia Trachomatis Current Events and Chlamydia Trachomatis News RSSNew chlamydia test offers rapid, pain-free test for men
A new urine test developed with funding from the Wellcome Trust will allow doctors to diagnose Chlamydia infection in men within the hour, improving the ability to successfully treat the infection on the spot and prevent re-transmission.
Chlamydia that avoids diagnosis
New sequencing and analysis of six strains Chlamydia will result in improved diagnosis of the sexually transmitted infection.
Researchers design unique method to induce immunity to certain STDs
Chlamydia trachomatis is the most common bacterial agent of sexually transmitted disease, accounting for more than a million reported infections in the United States each year.
Multiple species of bacteria may cause trachoma: Implications for treatment
In a study published in this week's PLoS Medicine, researchers have found that more than one species of bacteria may be causing the infectious eye disease trachoma.
Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
Scientists at Children's Hospital of Pittsburgh of UPMC have identified a potential target for the development of a vaccine against Chlamydia trachomatis, the most prevalent sexually transmitted bacterial infection in the world.
HPV vaccine does not appear to be effective for treating pre-existing HPV infection
For women with human papillomavirus (HPV) infection, use of the HPV-16/18 vaccine will not accelerate reduction of the virus and should not be used to treat the infection, according to a study in the August 15 issue of JAMA.
Proactive chlamydia screening is not good value for money
Proactive chlamydia screening for young adults is an expensive intervention that probably does not represent good value for money, concludes a study published on bmj.com today.
Opportunistic chlamydia screening 'not underpinned by sound evidence
The value of opportunistic chlamydia screening is called into question in this week's BMJ.
University and health science center in San Antonio collaborate to find chlamydia vaccine
It's the most common bacteria-related sexually transmitted disease in the United States, so researchers at The University of Texas at San Antonio's South Texas Center for Emerging Infectious Diseases (STCEID) and The University of Texas at San Antonio Health Science Center have partnered to discover a vaccine that will prevent Chlamydia.
Use of antibiotic to treat infectious eye disease trachoma may increase risk for reinfection
Use of the antibiotic azithromycin to treat trachoma in Vietnam resulted in an increase in the risk of re-infections.
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Infecciones por Chlamydia Trachomatis by Dr. Gabriel González-Almaráz (Author) Book in spanish about Chlamydia Trachomatis, with 14 chapters, 309 pages, 94 black/white illustrations, 46 charts, bibliographic references per chapter, 28X22 cm. Special emphasis in cytological diangnosis in ophthalmic pathology including the author's experience on hyperendemic form. |
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Genital Infection by Chlamydia Trachomatis (Current Topics in Infection, Vol 2) by J. D. Oriel (Author), G. L. Ridgway (Author) | |
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Chlamydia Trachomatis Tem Urethitis and Cervicitis Photographic Poster Print, 24x18 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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Prevalence of chlamydia trachomatis among active duty male soldiers reporting to a troop medical clinic for routine health care.(Original Article)(Clinical ... An article from: Southern Medical Journal by Jeffery P. Greene (Author), Elisabeth Stafford (Author) This digital document is an article from Southern Medical Journal, published by Thomson Gale on May 1, 2007. The length of the article is 2693 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Prevalence of chlamydia trachomatis among active duty male soldiers reporting to a troop medical clinic for routine health care.(Original Article)(Clinical report) Author: Jeffery P. Greene Publication: Southern Medical Journal (Magazine/Journal) Date: May 1, 2007 Publisher: Thomson Gale Volume: 100 Issue: 5 Page: 478(4) Article Type: Clinical... | |
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New lymphogranuloma venereum Chlamydia trachomatis variant, Amsterdam.(DISPATCHES): An article from: Emerging Infectious Diseases by Joke Spaargaren (Author), Han S.A. Fennema (Author), Servaas A. Morre (Author), Henry J.C. de Vries (Author), Roel A. Coutinho (Author) This digital document is an article from Emerging Infectious Diseases, published by U.S. National Center for Infectious Diseases on July 1, 2005. The length of the article is 1895 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: New lymphogranuloma venereum Chlamydia trachomatis variant, Amsterdam.(DISPATCHES) Author: Joke Spaargaren Publication: Emerging Infectious Diseases (Magazine/Journal) Date: July 1, 2005 Publisher: U.S. National Center for Infectious Diseases Volume: 11 Issue: 7 Page: 1090(3) Distributed by Thomson... | |
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Chlamydia control: components of an effective control strategy to reduce the incidence of chlamydia trachomatis.(STDs and Sexual/Reproductive Health): ... The Canadian Journal of Human Sexuality by David M. Patrick (Author) This digital document is an article from The Canadian Journal of Human Sexuality, published by SIECCAN, The Sex Information and Education Council of Canada on June 22, 1997. The length of the article is 4546 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the supplier: The genital infection of chlamydia is reported more often than any other communicable disease in North America. Women contracting chlamydia have a 10-40% rate of pelvic inflammatory disease. This disease can be prevented with behavioral change, screening of high risk groups with amplified DNA technology, introducing a single dose... | |
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